FitteR-CATABOLIC SIGNED
Survival of the Fittest: On how to enhance recovery from critical illness through learning from evolutionary conserved catabolic pathways
Total Cost €
0EC-Contrib. €
0Partnership
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Project "FitteR-CATABOLIC" data sheet
The following table provides information about the project.
| Coordinator |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 2˙500˙000 € |
| EC max contribution | 2˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-10-01 to 2023-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KATHOLIEKE UNIVERSITEIT LEUVEN | BE (LEUVEN) | coordinator | 2˙500˙000.00 |
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Project objective
Since a few decades, human patients who suffer from severe illnesses or multiple trauma, conditions that were previously lethal, are being treated in intensive care units (ICUs). Modern intensive care medicine bridges patients from life-threatening conditions to recovery with use of mechanical devices, vasoactive drugs and powerful anti-microbial agents. By postponing death, a new unnatural condition, intensive-care-dependent prolonged (>1 week) critical illness, has been created. About 25% of ICU patients today require prolonged intensive care, sometimes for weeks or months, and these patients are at high risk of death while consuming 75% of resources. Although the primary insult was adequately dealt with, many long-stay patients typically suffer from hypercatabolism, ICU-acquired brain dysfunction and polyneuropathy/myopathy leading to severe muscle weakness, further increasing the risk of late death. As hypercatabolism was considered the culprit, several anabolic interventions were tested, but these showed harm instead of benefit. We previously showed that fasting early during illness is superior to forceful feeding, pointing to certain benefits of catabolic responses. In healthy humans, fasting activates catabolism to provide substrates essential to protect and maintain brain and muscle function. This proposal aims to investigate whether evolutionary conserved catabolic fasting pathways, specifically lipolysis and ketogenesis, can be exploited in the search for prevention of brain dysfunction and muscle weakness in long-stay ICU patients, with the goal to identify a new metabolic intervention to enhance their recovery. The project builds further on our experience with bi-directional translational research - using human material whenever possible and a validated mouse model of sepsis-induced critical illness for objectives that cannot be addressed in patients - and aims to close the loop, from a novel concept to a large randomized controlled trial in patients.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Réjane Paumelle, Joel T. Haas, Nathalie Hennuyer, Eric Baugé, Yann Deleye, Dieter Mesotten, Lies Langouche, Jonathan Vanhoutte, Céline Cudejko, Kristiaan Wouters, Sarah Anissa Hannou, Vanessa Legry, Steve Lancel, Fanny Lalloyer, Arnaud Polizzi, Sarra Smati, Pierre Gourdy, Emmanuelle Vallez, Emmanuel Bouchaert, Bruno Derudas, Hélène Dehondt, Céline Gheeraert, Sébastien Fleury, Anne Tailleux, Hepatic PPARα is critical in the metabolic adaptation to sepsis published pages: 963-973, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.12.037 |
Journal of Hepatology 70/5 | 2019-10-08 |
| 2019 |
Chloë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe, Lies Langouche Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones published pages: 236, ISSN: 1364-8535, DOI: 10.1186/s13054-019-2506-6 |
Critical Care 23/1 | 2019-10-08 |
| 2019 |
E. van Puffelen, J.M. Hulst, I. Vanhorebeek, K. Dulfer, G. Van den Berghe, K.F.M. Joosten, S.C.A.T. Verbruggen Effect of late versus early initiation of parenteral nutrition on weight deterioration during PICU stay: Secondary analysis of the PEPaNIC randomised controlled trial published pages: , ISSN: 0261-5614, DOI: 10.1016/j.clnu.2019.02.014 |
Clinical Nutrition | 2019-10-07 |
| 2019 |
Greet Van den Berghe Paediatric critical care survival: how to avoid bias published pages: e2, ISSN: 2213-2600, DOI: 10.1016/S2213-2600(18)30408-9 |
The Lancet Respiratory Medicine 7/2 | 2019-10-07 |
| 2019 |
Jan Gunst, Astrid De Bruyn, Greet Van den Berghe Glucose control in the ICU published pages: 156-162, ISSN: 0952-7907, DOI: 10.1097/ACO.0000000000000706 |
Current Opinion in Anaesthesiology 32/2 | 2019-10-07 |
| 2018 |
Esther van Puffelen, Jessie M. Hulst, Ilse Vanhorebeek, Karolijn Dulfer, Greet Van den Berghe, Sascha C. A. T. Verbruggen, Koen F. M. Joosten Outcomes of Delaying Parenteral Nutrition for 1 Week vs Initiation Within 24 Hours Among Undernourished Children in Pediatric Intensive Care published pages: e182668, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2018.2668 |
JAMA Network Open 1/5 | 2019-10-07 |
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