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MORPHEUS SIGNED

Deciphering Bacteria-induced Morphogenesis and Protection in marine Eukaryotes

Total Cost €

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EC-Contrib. €

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Partnership

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 MORPHEUS project word cloud

Explore the words cloud of the MORPHEUS project. It provides you a very rough idea of what is the project "MORPHEUS" about.

innovative    drivers    marine    lineage    biochemical    symbiotic    reproduces    intrinsic    recruitment    protected    developmental    colonial    metazoan    symbiosis    organic    evolutionary    chemistry    molecular    perception    bacterial    dies    play    hydroid    disciplines    metamorphosis    signalling    insights    humans    larval    stage    mechanisms    strategies    synthetic    paradigmatic    pursue    roles    critical    combination    scientific    branches    capitalizing    fails    species    transformative    gap    urgently    perceived    branching    drug    morphogenic    pioneering    metabolism    erc    morphogenesis    cross    500    animals    basis    absence    larva    breaking    biofouling    model    sustainable    transformation    bacteria    ground    fundamental    cellular    pressing    eukaryotic    mature    microbiology    biology    signals    back    unidentified    kingdom    illuminate    interactions    settle    undergoes    organism    morpheus    fill    alien    discovery    biological    dating    evolution    natural    questions    chemical    underlying    largely    biofilms    million    animal    unknown    history    anti    scaffolds    molecules    belongs    hydractinia   

Project "MORPHEUS" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT 

Organization address
address: BEUTENBERG STRASSE 11A
city: JENA
postcode: 7745
website: http://www2.hki-jena.de/rz/hki_i00.htm

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) coordinator 1˙498˙750.00

Map

 Project objective

Symbiotic bacteria play critical roles in animal evolution, development and metabolism. The molecular and cellular mechanisms underlying these fundamental interactions, however, are largely unknown.

To fill this major knowledge gap, I will establish the bacteria-Hydractinia symbiosis as a new model system to fully characterize key cross-kingdom signalling molecules and response mechanisms. The results of my ERC proposal (MORPHEUS) will lead to ground-breaking insights into molecular drivers of eukaryotic morphogenesis, illuminate the evolutionary history of developmental signals for animals – including humans – and provide new chemical scaffolds with intrinsic biological activities that are urgently needed for drug discovery.

The marine colonial hydroid Hydractinia belongs to an early branching metazoan lineage, dating back more than 500 million years. The organism reproduces through a larval stage, which upon perception of yet unidentified bacterial morphogenic signals, produced within marine bacterial biofilms, undergoes transformation into the mature organism. In the absence of the bacterial signals, the larva fails to settle and eventually dies. This fundamental process is the basis of this proposal. Capitalizing from my recent pioneering work, I will address the following pressing research questions: Which bacterial signals ensure larval recruitment and metamorphosis? How are bacterial signalling molecules perceived? How is the system protected against alien species? I will apply an innovative combination of state-of-the-art methodologies developed within the fields of natural product and synthetic organic chemistry, microbiology and molecular biology to pursue an in-depth biochemical analysis of this paradigmatic system. Results of MORPHEUS will be transformative for many scientific branches across biological and chemical disciplines, and directly impact the development of sustainable anti-biofouling and drug discovery strategies.

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The information about "MORPHEUS" are provided by the European Opendata Portal: CORDIS opendata.

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