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MORPHEUS SIGNED

Deciphering Bacteria-induced Morphogenesis and Protection in marine Eukaryotes

Total Cost €

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EC-Contrib. €

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Partnership

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 MORPHEUS project word cloud

Explore the words cloud of the MORPHEUS project. It provides you a very rough idea of what is the project "MORPHEUS" about.

lineage    perception    developmental    mature    eukaryotic    pioneering    erc    questions    branches    undergoes    cross    marine    chemical    history    stage    animals    bacteria    dies    synthetic    anti    dating    pursue    sustainable    hydroid    metazoan    illuminate    unidentified    transformative    settle    drivers    combination    discovery    model    evolutionary    strategies    cellular    larva    500    kingdom    metamorphosis    chemistry    basis    disciplines    reproduces    molecular    scaffolds    paradigmatic    natural    absence    morpheus    belongs    interactions    mechanisms    morphogenic    organic    underlying    million    hydractinia    signals    play    alien    symbiosis    bacterial    ground    fails    roles    scientific    branching    drug    protected    unknown    transformation    humans    intrinsic    biofilms    fill    microbiology    species    largely    organism    biofouling    pressing    back    gap    larval    perceived    biology    molecules    insights    innovative    urgently    fundamental    animal    signalling    colonial    critical    metabolism    breaking    evolution    capitalizing    biological    symbiotic    morphogenesis    biochemical    recruitment   

Project "MORPHEUS" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT 

Organization address
address: BEUTENBERG STRASSE 11A
city: JENA
postcode: 7745
website: http://www2.hki-jena.de/rz/hki_i00.htm

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) coordinator 1˙498˙750.00

Map

 Project objective

Symbiotic bacteria play critical roles in animal evolution, development and metabolism. The molecular and cellular mechanisms underlying these fundamental interactions, however, are largely unknown.

To fill this major knowledge gap, I will establish the bacteria-Hydractinia symbiosis as a new model system to fully characterize key cross-kingdom signalling molecules and response mechanisms. The results of my ERC proposal (MORPHEUS) will lead to ground-breaking insights into molecular drivers of eukaryotic morphogenesis, illuminate the evolutionary history of developmental signals for animals – including humans – and provide new chemical scaffolds with intrinsic biological activities that are urgently needed for drug discovery.

The marine colonial hydroid Hydractinia belongs to an early branching metazoan lineage, dating back more than 500 million years. The organism reproduces through a larval stage, which upon perception of yet unidentified bacterial morphogenic signals, produced within marine bacterial biofilms, undergoes transformation into the mature organism. In the absence of the bacterial signals, the larva fails to settle and eventually dies. This fundamental process is the basis of this proposal. Capitalizing from my recent pioneering work, I will address the following pressing research questions: Which bacterial signals ensure larval recruitment and metamorphosis? How are bacterial signalling molecules perceived? How is the system protected against alien species? I will apply an innovative combination of state-of-the-art methodologies developed within the fields of natural product and synthetic organic chemistry, microbiology and molecular biology to pursue an in-depth biochemical analysis of this paradigmatic system. Results of MORPHEUS will be transformative for many scientific branches across biological and chemical disciplines, and directly impact the development of sustainable anti-biofouling and drug discovery strategies.

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The information about "MORPHEUS" are provided by the European Opendata Portal: CORDIS opendata.

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