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MORPHEUS SIGNED

Deciphering Bacteria-induced Morphogenesis and Protection in marine Eukaryotes

Total Cost €

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EC-Contrib. €

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Partnership

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 MORPHEUS project word cloud

Explore the words cloud of the MORPHEUS project. It provides you a very rough idea of what is the project "MORPHEUS" about.

molecular    unknown    pioneering    sustainable    animals    animal    settle    biology    branches    organism    cellular    model    500    organic    signalling    protected    perceived    strategies    erc    bacteria    dating    bacterial    symbiosis    largely    synthetic    metazoan    chemical    pressing    pursue    intrinsic    branching    illuminate    metamorphosis    cross    perception    unidentified    ground    drug    morphogenic    larval    fundamental    evolutionary    microbiology    developmental    play    natural    morphogenesis    back    critical    urgently    paradigmatic    history    humans    interactions    belongs    capitalizing    insights    molecules    biofilms    recruitment    metabolism    roles    breaking    evolution    combination    transformation    stage    fill    discovery    colonial    biochemical    signals    hydractinia    marine    lineage    species    basis    dies    innovative    transformative    scientific    million    alien    drivers    larva    hydroid    mechanisms    anti    chemistry    reproduces    morpheus    fails    absence    biological    underlying    symbiotic    scaffolds    gap    undergoes    mature    questions    kingdom    eukaryotic    biofouling    disciplines   

Project "MORPHEUS" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT 

Organization address
address: BEUTENBERG STRASSE 11A
city: JENA
postcode: 7745
website: http://www2.hki-jena.de/rz/hki_i00.htm

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) coordinator 1˙498˙750.00

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 Project objective

Symbiotic bacteria play critical roles in animal evolution, development and metabolism. The molecular and cellular mechanisms underlying these fundamental interactions, however, are largely unknown.

To fill this major knowledge gap, I will establish the bacteria-Hydractinia symbiosis as a new model system to fully characterize key cross-kingdom signalling molecules and response mechanisms. The results of my ERC proposal (MORPHEUS) will lead to ground-breaking insights into molecular drivers of eukaryotic morphogenesis, illuminate the evolutionary history of developmental signals for animals – including humans – and provide new chemical scaffolds with intrinsic biological activities that are urgently needed for drug discovery.

The marine colonial hydroid Hydractinia belongs to an early branching metazoan lineage, dating back more than 500 million years. The organism reproduces through a larval stage, which upon perception of yet unidentified bacterial morphogenic signals, produced within marine bacterial biofilms, undergoes transformation into the mature organism. In the absence of the bacterial signals, the larva fails to settle and eventually dies. This fundamental process is the basis of this proposal. Capitalizing from my recent pioneering work, I will address the following pressing research questions: Which bacterial signals ensure larval recruitment and metamorphosis? How are bacterial signalling molecules perceived? How is the system protected against alien species? I will apply an innovative combination of state-of-the-art methodologies developed within the fields of natural product and synthetic organic chemistry, microbiology and molecular biology to pursue an in-depth biochemical analysis of this paradigmatic system. Results of MORPHEUS will be transformative for many scientific branches across biological and chemical disciplines, and directly impact the development of sustainable anti-biofouling and drug discovery strategies.

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The information about "MORPHEUS" are provided by the European Opendata Portal: CORDIS opendata.

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