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MORPHEUS SIGNED

Deciphering Bacteria-induced Morphogenesis and Protection in marine Eukaryotes

Total Cost €

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EC-Contrib. €

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Partnership

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 MORPHEUS project word cloud

Explore the words cloud of the MORPHEUS project. It provides you a very rough idea of what is the project "MORPHEUS" about.

breaking    transformative    hydroid    questions    pioneering    biochemical    interactions    combination    branches    perceived    stage    cross    molecular    chemistry    metazoan    sustainable    biofilms    evolution    belongs    reproduces    innovative    natural    play    evolutionary    colonial    lineage    morpheus    morphogenic    pressing    biofouling    eukaryotic    symbiosis    critical    undergoes    roles    erc    microbiology    mature    discovery    larval    gap    chemical    bacteria    urgently    unknown    perception    ground    capitalizing    underlying    scaffolds    fails    anti    animals    absence    metamorphosis    organism    basis    dies    metabolism    animal    million    settle    pursue    disciplines    kingdom    intrinsic    signalling    morphogenesis    organic    500    alien    drug    developmental    drivers    species    mechanisms    fundamental    recruitment    fill    larva    scientific    transformation    back    dating    insights    biological    symbiotic    strategies    largely    protected    cellular    marine    paradigmatic    illuminate    synthetic    humans    branching    model    molecules    signals    unidentified    bacterial    history    biology    hydractinia   

Project "MORPHEUS" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT 

Organization address
address: BEUTENBERG STRASSE 11A
city: JENA
postcode: 7745
website: http://www2.hki-jena.de/rz/hki_i00.htm

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) coordinator 1˙498˙750.00

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 Project objective

Symbiotic bacteria play critical roles in animal evolution, development and metabolism. The molecular and cellular mechanisms underlying these fundamental interactions, however, are largely unknown.

To fill this major knowledge gap, I will establish the bacteria-Hydractinia symbiosis as a new model system to fully characterize key cross-kingdom signalling molecules and response mechanisms. The results of my ERC proposal (MORPHEUS) will lead to ground-breaking insights into molecular drivers of eukaryotic morphogenesis, illuminate the evolutionary history of developmental signals for animals – including humans – and provide new chemical scaffolds with intrinsic biological activities that are urgently needed for drug discovery.

The marine colonial hydroid Hydractinia belongs to an early branching metazoan lineage, dating back more than 500 million years. The organism reproduces through a larval stage, which upon perception of yet unidentified bacterial morphogenic signals, produced within marine bacterial biofilms, undergoes transformation into the mature organism. In the absence of the bacterial signals, the larva fails to settle and eventually dies. This fundamental process is the basis of this proposal. Capitalizing from my recent pioneering work, I will address the following pressing research questions: Which bacterial signals ensure larval recruitment and metamorphosis? How are bacterial signalling molecules perceived? How is the system protected against alien species? I will apply an innovative combination of state-of-the-art methodologies developed within the fields of natural product and synthetic organic chemistry, microbiology and molecular biology to pursue an in-depth biochemical analysis of this paradigmatic system. Results of MORPHEUS will be transformative for many scientific branches across biological and chemical disciplines, and directly impact the development of sustainable anti-biofouling and drug discovery strategies.

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The information about "MORPHEUS" are provided by the European Opendata Portal: CORDIS opendata.

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