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MORPHEUS SIGNED

Deciphering Bacteria-induced Morphogenesis and Protection in marine Eukaryotes

Total Cost €

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EC-Contrib. €

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Partnership

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 MORPHEUS project word cloud

Explore the words cloud of the MORPHEUS project. It provides you a very rough idea of what is the project "MORPHEUS" about.

disciplines    biological    fill    morphogenesis    chemical    absence    signals    belongs    lineage    fundamental    marine    pressing    synthetic    chemistry    transformation    kingdom    evolutionary    underlying    morphogenic    pursue    protected    questions    back    anti    illuminate    alien    transformative    combination    erc    eukaryotic    recruitment    symbiosis    play    discovery    unknown    stage    bacterial    strategies    animal    molecules    breaking    organic    dating    insights    fails    bacteria    branches    microbiology    innovative    symbiotic    drug    largely    history    biochemical    cellular    interactions    molecular    drivers    basis    hydractinia    biofilms    branching    natural    urgently    undergoes    500    organism    perception    unidentified    sustainable    paradigmatic    roles    perceived    metazoan    scientific    metamorphosis    species    morpheus    settle    humans    pioneering    biology    hydroid    reproduces    larval    animals    scaffolds    larva    colonial    metabolism    biofouling    dies    ground    critical    million    mechanisms    evolution    developmental    signalling    intrinsic    capitalizing    mature    gap    model    cross   

Project "MORPHEUS" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT 

Organization address
address: BEUTENBERG STRASSE 11A
city: JENA
postcode: 7745
website: http://www2.hki-jena.de/rz/hki_i00.htm

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) coordinator 1˙498˙750.00

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 Project objective

Symbiotic bacteria play critical roles in animal evolution, development and metabolism. The molecular and cellular mechanisms underlying these fundamental interactions, however, are largely unknown.

To fill this major knowledge gap, I will establish the bacteria-Hydractinia symbiosis as a new model system to fully characterize key cross-kingdom signalling molecules and response mechanisms. The results of my ERC proposal (MORPHEUS) will lead to ground-breaking insights into molecular drivers of eukaryotic morphogenesis, illuminate the evolutionary history of developmental signals for animals – including humans – and provide new chemical scaffolds with intrinsic biological activities that are urgently needed for drug discovery.

The marine colonial hydroid Hydractinia belongs to an early branching metazoan lineage, dating back more than 500 million years. The organism reproduces through a larval stage, which upon perception of yet unidentified bacterial morphogenic signals, produced within marine bacterial biofilms, undergoes transformation into the mature organism. In the absence of the bacterial signals, the larva fails to settle and eventually dies. This fundamental process is the basis of this proposal. Capitalizing from my recent pioneering work, I will address the following pressing research questions: Which bacterial signals ensure larval recruitment and metamorphosis? How are bacterial signalling molecules perceived? How is the system protected against alien species? I will apply an innovative combination of state-of-the-art methodologies developed within the fields of natural product and synthetic organic chemistry, microbiology and molecular biology to pursue an in-depth biochemical analysis of this paradigmatic system. Results of MORPHEUS will be transformative for many scientific branches across biological and chemical disciplines, and directly impact the development of sustainable anti-biofouling and drug discovery strategies.

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The information about "MORPHEUS" are provided by the European Opendata Portal: CORDIS opendata.

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