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NeuHeart SIGNED

A neuroprosthesis to restore the vagal-cardiac closed-loop connection after heart transplantation

Total Cost €

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EC-Contrib. €

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Partnership

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NeuHeart project word cloud

Explore the words cloud of the NeuHeart project. It provides you a very rough idea of what is the project "NeuHeart" about.

swine transplantation hf denervated worldwide furthered industry regenerative interface record neuromodulation oht solution smart neuheart science clinical artificially sensors establising complete complications quality expectancy health paradigm re connection remarkably life incompetence patients techniques impacts neuroprosthesis limited cardiac artificial treatment multiple native fundamental recipients exercise clinics sensory contractility altered stage significantly owing mainly medicine neural vn stimulation surgical vagal close nerve loop chronotropic bioelectronic 3500 implanted model rate feasibility modulation orthotopic mover physiology donor with market load surgeries inevitable guaranteeing first annual htx position society tested transplant relationship frequency heart capacity denervation last constitution closed vagus output resort unfortunately explantation

Project "NeuHeart" data sheet

The following table provides information about the project.

Coordinator	SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA Organization address address: PIAZZA MARTIRI DELLA LIBERTA 33 city: PISA postcode: 56127 website: www.sssup.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	4˙983˙465 €
EC max contribution	4˙983˙465 € (100%)
Programme	1. H2020-EU.1.2.2. (FET Proactive)
Code Call	H2020-FETPROACT-2018-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA Organization address address: PIAZZA MARTIRI DELLA LIBERTA 33 city: PISA postcode: 56127 website: www.sssup.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PISA)	coordinator	1˙528˙250.00
2	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	1˙036˙287.00
3	FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT Organization address address: ZEUGHAUSSTRASSE 43 city: ZURICH postcode: 8004 website: http://www.itis.ethz.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	724˙705.00
4	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	695˙977.00
5	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	600˙745.00
6	SENSARS NEUROPROSTHETICS SARL SENSARS NEUROPROSTHETICS SARL Organization address address: RUE DU MAUPAS 38 city: LAUSANNE postcode: 1004 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	397˙500.00

Map

Project objective

With 3500 annual surgeries worldwide, heart transplantation is the last resort for an increasing number of patients affected by end-stage heart failure (HF). Heart transplant (HTx) can significantly increase life expectancy of HF patients but unfortunately exercise capacity and health-related quality of life of HTx recipients are still limited, due to the increased frequency of late complications mainly owing to chronotropic incompetence because of cardiac denervation. Orthotopic heart transplantation (OHT) is the most common approach of HTx, involving the complete explantation of the native heart, making surgical denervation inevitable. Therefore, the modulation of rate- and load-contractility relationship of the donor heart is significantly altered after transplantation even if using different surgical techniques. Addressing this fundamental clinical problem is the main goal of NeuHeart, that will be furthered by specifically investigating the physiology of denervated heart which will facilitate the development of a bioelectronic solution based on the closed-loop neuromodulation of the vagus nerve (VN), using a regenerative neural interface (for VN stimulation) and implanted artificial sensors (to record sensory information and close the loop). This cardiac smart neuroprosthesis will be tested in a swine model of OHT to demonstrate the feasibility of artificially re-establising vagal control in a denervated heart, by re-enabling the cardiac-vagal connection: the overall research output of the project will deliver multiple impacts, remarkably contributing to heart transplant science (fundamental research), help in the constitution of a new treatment paradigm for heart failure (clinics and society), and reach into the emerging industry of bioelectronic medicine (technology market), guaranteeing Europe a position of ‘first mover’ into this field.

Publications

List of publications.
year	authors and title	journal	last update
2019	Annarita Cutrone, Silvestro Micera Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems published pages: 1801345, ISSN: 2192-2640, DOI: 10.1002/adhm.201801345	Advanced Healthcare Materials 8/24	2020-04-16

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The information about "NEUHEART" are provided by the European Opendata Portal: CORDIS opendata.

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