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NeuHeart SIGNED

A neuroprosthesis to restore the vagal-cardiac closed-loop connection after heart transplantation

Total Cost €

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EC-Contrib. €

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Partnership

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 NeuHeart project word cloud

Explore the words cloud of the NeuHeart project. It provides you a very rough idea of what is the project "NeuHeart" about.

worldwide    sensors    neuromodulation    clinics    surgical    establising    vagus    furthered    3500    society    recipients    tested    expectancy    treatment    artificially    neural    transplant    oht    cardiac    patients    mover    neuheart    denervated    altered    re    with    relationship    medicine    htx    model    resort    transplantation    frequency    closed    close    load    neuroprosthesis    artificial    feasibility    fundamental    market    guaranteeing    denervation    vagal    contractility    inevitable    mainly    surgeries    limited    industry    hf    record    vn    stimulation    bioelectronic    multiple    significantly    modulation    heart    connection    incompetence    interface    complications    donor    rate    implanted    position    chronotropic    solution    paradigm    smart    native    stage    regenerative    remarkably    first    physiology    output    constitution    clinical    explantation    impacts    loop    swine    life    last    sensory    techniques    quality    nerve    science    owing    capacity    annual    unfortunately    exercise    complete    health    orthotopic   

Project "NeuHeart" data sheet

The following table provides information about the project.

Coordinator
SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA 

Organization address
address: PIAZZA MARTIRI DELLA LIBERTA 33
city: PISA
postcode: 56127
website: www.sssup.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 4˙983˙465 €
 EC max contribution 4˙983˙465 € (100%)
 Programme 1. H2020-EU.1.2.2. (FET Proactive)
 Code Call H2020-FETPROACT-2018-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA IT (PISA) coordinator 1˙528˙250.00
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 1˙036˙287.00
3    FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT CH (ZURICH) participant 724˙705.00
4    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 695˙977.00
5    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 600˙745.00
6    SENSARS NEUROPROSTHETICS SARL CH (LAUSANNE) participant 397˙500.00

Map

 Project objective

With 3500 annual surgeries worldwide, heart transplantation is the last resort for an increasing number of patients affected by end-stage heart failure (HF). Heart transplant (HTx) can significantly increase life expectancy of HF patients but unfortunately exercise capacity and health-related quality of life of HTx recipients are still limited, due to the increased frequency of late complications mainly owing to chronotropic incompetence because of cardiac denervation. Orthotopic heart transplantation (OHT) is the most common approach of HTx, involving the complete explantation of the native heart, making surgical denervation inevitable. Therefore, the modulation of rate- and load-contractility relationship of the donor heart is significantly altered after transplantation even if using different surgical techniques. Addressing this fundamental clinical problem is the main goal of NeuHeart, that will be furthered by specifically investigating the physiology of denervated heart which will facilitate the development of a bioelectronic solution based on the closed-loop neuromodulation of the vagus nerve (VN), using a regenerative neural interface (for VN stimulation) and implanted artificial sensors (to record sensory information and close the loop). This cardiac smart neuroprosthesis will be tested in a swine model of OHT to demonstrate the feasibility of artificially re-establising vagal control in a denervated heart, by re-enabling the cardiac-vagal connection: the overall research output of the project will deliver multiple impacts, remarkably contributing to heart transplant science (fundamental research), help in the constitution of a new treatment paradigm for heart failure (clinics and society), and reach into the emerging industry of bioelectronic medicine (technology market), guaranteeing Europe a position of ‘first mover’ into this field.

 Publications

year authors and title journal last update
List of publications.
2019 Annarita Cutrone, Silvestro Micera
Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems
published pages: 1801345, ISSN: 2192-2640, DOI: 10.1002/adhm.201801345
Advanced Healthcare Materials 8/24 2020-04-16

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The information about "NEUHEART" are provided by the European Opendata Portal: CORDIS opendata.

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