EU H2020 Project "NEUHEART (A neuroprosthesis to restore the vagal-cardiac closed-loop connection after..)": description, partecipants, costs and EC-fundings

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NeuHeart project word cloud

Explore the words cloud of the NeuHeart project. It provides you a very rough idea of what is the project "NeuHeart" about.

explantation medicine life surgical 3500 significantly model regenerative clinics establising fundamental output science complications exercise vagal limited furthered frequency donor connection re smart transplantation mover vagus with neural constitution swine annual recipients oht remarkably paradigm native inevitable capacity loop expectancy neuromodulation worldwide denervation treatment implanted stage modulation hf contractility first health orthotopic unfortunately stimulation neuroprosthesis close nerve industry patients load mainly chronotropic artificial society cardiac sensory sensors physiology impacts owing guaranteeing feasibility multiple altered resort incompetence complete relationship htx bioelectronic neuheart vn techniques tested solution market surgeries denervated interface last rate artificially quality closed heart position record transplant clinical

Project "NeuHeart" data sheet

The following table provides information about the project.

Coordinator	SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA Organization address address: PIAZZA MARTIRI DELLA LIBERTA 33 city: PISA postcode: 56127 website: www.sssup.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	4˙983˙465 €
EC max contribution	4˙983˙465 € (100%)
Programme	1. H2020-EU.1.2.2. (FET Proactive)
Code Call	H2020-FETPROACT-2018-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

#	participants	country	role	EC contrib. [€]
1	SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA	IT (PISA)	coordinator	1˙528˙250.00
2	UNIVERSITY COLLEGE LONDON	UK (LONDON)	participant	1˙036˙287.00
3	FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT	CH (ZURICH)	participant	724˙705.00
4	MEDIZINISCHE UNIVERSITAET WIEN	AT (WIEN)	participant	695˙977.00
5	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.	DE (MUNCHEN)	participant	600˙745.00
6	SENSARS NEUROPROSTHETICS SARL	CH (LAUSANNE)	participant	397˙500.00

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA

IT (PISA)

coordinator

1˙528˙250.00

UNIVERSITY COLLEGE LONDON

UK (LONDON)

participant

1˙036˙287.00

FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT

CH (ZURICH)

participant

724˙705.00

MEDIZINISCHE UNIVERSITAET WIEN

AT (WIEN)

participant

695˙977.00

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

DE (MUNCHEN)

participant

600˙745.00

SENSARS NEUROPROSTHETICS SARL

CH (LAUSANNE)

participant

397˙500.00

Project objective

With 3500 annual surgeries worldwide, heart transplantation is the last resort for an increasing number of patients affected by end-stage heart failure (HF). Heart transplant (HTx) can significantly increase life expectancy of HF patients but unfortunately exercise capacity and health-related quality of life of HTx recipients are still limited, due to the increased frequency of late complications mainly owing to chronotropic incompetence because of cardiac denervation. Orthotopic heart transplantation (OHT) is the most common approach of HTx, involving the complete explantation of the native heart, making surgical denervation inevitable. Therefore, the modulation of rate- and load-contractility relationship of the donor heart is significantly altered after transplantation even if using different surgical techniques. Addressing this fundamental clinical problem is the main goal of NeuHeart, that will be furthered by specifically investigating the physiology of denervated heart which will facilitate the development of a bioelectronic solution based on the closed-loop neuromodulation of the vagus nerve (VN), using a regenerative neural interface (for VN stimulation) and implanted artificial sensors (to record sensory information and close the loop). This cardiac smart neuroprosthesis will be tested in a swine model of OHT to demonstrate the feasibility of artificially re-establising vagal control in a denervated heart, by re-enabling the cardiac-vagal connection: the overall research output of the project will deliver multiple impacts, remarkably contributing to heart transplant science (fundamental research), help in the constitution of a new treatment paradigm for heart failure (clinics and society), and reach into the emerging industry of bioelectronic medicine (technology market), guaranteeing Europe a position of ‘first mover’ into this field.

Publications

List of publications.
year	authors and title	journal	last update
2019	Annarita Cutrone, Silvestro Micera Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems published pages: 1801345, ISSN: 2192-2640, DOI: 10.1002/adhm.201801345	Advanced Healthcare Materials 8/24	2020-04-16

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The information about "NEUHEART" are provided by the European Opendata Portal: CORDIS opendata.

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