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CELLONGATE SIGNED

Unraveling the molecular network that drives cell growth in plants

Total Cost €

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EC-Contrib. €

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Partnership

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 CELLONGATE project word cloud

Explore the words cloud of the CELLONGATE project. It provides you a very rough idea of what is the project "CELLONGATE" about.

transcriptome    organ    consequently    discovery    steering    encased    map    resolution    strength    microfluidic    effect    plants    molecular    orientation    elusive    gravity    temporal    occurs    precise    combine    methodology    migrate    parallel    chip    pressurized    roots    discover    acquisition    platform    nutrient    developmental    strikingly    organs    hydrostatic    termination    similarly    profiles    size    differ    individual    protein    thaliana    spatio    root    cellular    central    consists    almost    optimized    onset    skeleton    animals    cell    though    dynamic    move    gradients    massive    epicenter    wall    manipulation    plant    setup    optimize    microscopy    am    mechanism    arabidopsis    tip    division    turgor    light    equipped    auxin    strict    chart    imaging    exemplified    physiological    pressure    mechanisms    correlating    sculpture    despite    immobility    elongation    movements    regulation    differential    cells    genes    vector    window    depends    balance    unknown    unravel    types    live    internal    phytohormone    lab    migration    orient    networks    gene    total    steer    absence    physiology    regulator    bodies   

Project "CELLONGATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERZITA KARLOVA 

Organization address
address: OVOCNY TRH 560/5
city: PRAHA 1
postcode: 116 36
website: www.cuni.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERZITA KARLOVA CZ (PRAHA 1) coordinator 1˙498˙750.00

Map

 Project objective

Plants differ strikingly from animals by the almost total absence of cell migration in their development. Plants build their bodies using a hydrostatic skeleton that consists of pressurized cells encased by a cell wall. Consequently, plant cells cannot migrate and must sculpture their bodies by orientation of cell division and precise regulation of cell growth. Cell growth depends on the balance between internal cell pressure – turgor, and strength of the cell wall. Cell growth is under a strict developmental control, which is exemplified in the Arabidopsis thaliana root tip, where massive cell elongation occurs in a defined spatio-temporal developmental window. Despite the immobility of their cells, plant organs move to optimize light and nutrient acquisition and to orient their bodies along the gravity vector. These movements depend on differential regulation of cell elongation across the organ, and on response to the phytohormone auxin. Even though the control of cell growth is in the epicenter of plant development, protein networks steering the developmental growth onset, coordination and termination remain elusive. Similarly, although auxin is the central regulator of growth, the molecular mechanism of its effect on root growth is unknown. In this project, I will establish a unique microscopy setup for high spatio-temporal resolution live-cell imaging equipped with a microfluidic lab-on-chip platform optimized for growing roots, to enable analysis and manipulation of root growth physiology. I will use developmental gradients in the root to discover genes that steer cellular growth, by correlating transcriptome profiles of individual cell types with the cell size. In parallel, I will exploit the auxin effect on root to unravel molecular mechanisms that control cell elongation. Finally, I am going to combine the live-cell imaging methodology with the gene discovery approaches to chart a dynamic spatio-temporal physiological map of a growing Arabidopsis root.

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The information about "CELLONGATE" are provided by the European Opendata Portal: CORDIS opendata.

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