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CELLONGATE SIGNED

Unraveling the molecular network that drives cell growth in plants

Total Cost €

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EC-Contrib. €

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Partnership

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 CELLONGATE project word cloud

Explore the words cloud of the CELLONGATE project. It provides you a very rough idea of what is the project "CELLONGATE" about.

migration    organs    absence    skeleton    platform    spatio    chip    equipped    roots    lab    turgor    sculpture    cells    arabidopsis    root    depends    effect    optimize    consequently    molecular    strikingly    individual    parallel    thaliana    discover    tip    orient    types    imaging    protein    differential    encased    live    elusive    setup    steer    central    microscopy    acquisition    phytohormone    manipulation    epicenter    chart    profiles    plants    massive    migrate    light    exemplified    auxin    dynamic    internal    movements    almost    elongation    cellular    wall    gradients    microfluidic    division    unknown    differ    steering    window    immobility    map    gene    temporal    genes    developmental    move    animals    plant    physiological    physiology    cell    combine    similarly    resolution    pressurized    bodies    am    consists    occurs    methodology    onset    pressure    discovery    gravity    mechanisms    transcriptome    regulation    correlating    orientation    termination    optimized    organ    vector    strict    networks    mechanism    precise    total    strength    hydrostatic    nutrient    size    unravel    though    despite    regulator    balance   

Project "CELLONGATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERZITA KARLOVA 

Organization address
address: OVOCNY TRH 560/5
city: PRAHA 1
postcode: 116 36
website: www.cuni.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERZITA KARLOVA CZ (PRAHA 1) coordinator 1˙498˙750.00

Map

 Project objective

Plants differ strikingly from animals by the almost total absence of cell migration in their development. Plants build their bodies using a hydrostatic skeleton that consists of pressurized cells encased by a cell wall. Consequently, plant cells cannot migrate and must sculpture their bodies by orientation of cell division and precise regulation of cell growth. Cell growth depends on the balance between internal cell pressure – turgor, and strength of the cell wall. Cell growth is under a strict developmental control, which is exemplified in the Arabidopsis thaliana root tip, where massive cell elongation occurs in a defined spatio-temporal developmental window. Despite the immobility of their cells, plant organs move to optimize light and nutrient acquisition and to orient their bodies along the gravity vector. These movements depend on differential regulation of cell elongation across the organ, and on response to the phytohormone auxin. Even though the control of cell growth is in the epicenter of plant development, protein networks steering the developmental growth onset, coordination and termination remain elusive. Similarly, although auxin is the central regulator of growth, the molecular mechanism of its effect on root growth is unknown. In this project, I will establish a unique microscopy setup for high spatio-temporal resolution live-cell imaging equipped with a microfluidic lab-on-chip platform optimized for growing roots, to enable analysis and manipulation of root growth physiology. I will use developmental gradients in the root to discover genes that steer cellular growth, by correlating transcriptome profiles of individual cell types with the cell size. In parallel, I will exploit the auxin effect on root to unravel molecular mechanisms that control cell elongation. Finally, I am going to combine the live-cell imaging methodology with the gene discovery approaches to chart a dynamic spatio-temporal physiological map of a growing Arabidopsis root.

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The information about "CELLONGATE" are provided by the European Opendata Portal: CORDIS opendata.

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