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Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly

Total Cost €


EC-Contrib. €






Project "CATCH ME" data sheet

The following table provides information about the project.


Organization address
address: Edgbaston
postcode: B15 2TT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 4˙944˙773 €
 EC max contribution 4˙944˙773 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2019-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 1˙303˙366.00
3    KOMPETENZNETZ VORHOFFLIMMERN E.V. DE (Muenster) participant 567˙500.00
8    SORBONNE UNIVERSITE FR (PARIS) participant 383˙367.00


 Project objective

Atrial fibrillation (AF) is the most common cardiac arrhythmia, with a prevalence of 1.5-2% in European populations. By being a major cause of stroke, dementia, heart failure, and premature death, AF is a major threat to healthy ageing. Despite increasing knowledge on the diverse mechanisms that cause the AF substrate in individual patients, current strategies for prevention and therapy of AF remain largely unguided by mechanistic insights. As a result - with the exception of anticoagulation for the prevention of AF-related stroke – treatment of AF has thus far failed to improve patients’ outcome. The CATCH ME consortium will bridge the present disconnect between our understanding of the molecular and electrophysiological mechanisms of AF and the current unstructured approach to its prevention and treatment. The consortium combines clinical, molecular, ECG engineering, and biostatistical expertise, and has access to large sets of human biological material (atrial tissue and bloods samples) and carefully phenotyped patient populations. Together, we will identify and integrate the main drivers of prevalent and incident AF in patients, and validate new ECG- and blood based markers in well-characterized cohorts. The results of these investigations will provide a quantitative estimate of the prevalence and impact of new and established risk factors for AF in Europe and uncover potential new targets and strategies for the prevention and treatment of this arrhythmia. We will integrate these factors into a new clinical classification of AF that will be externally validated in two large patient cohorts, including response to current treatment strategies, and AF-related complications. In summary, CATCH ME will 1. identify major AF-related modifiers of health in the elderly in Europe, 2. develop clinical tools that have the potential of transforming the management of AF in individual patients, and 3. inform future personalized strategies to prevent and treat AF in Europe.


List of deliverables.
Certification of the CATCH ME classification e-learning module by the European Board for Accreditation in Cardiology (EBAC) Documents, reports 2020-01-14 15:26:16
Scientific papers published in peer reviewed international journals. Documents, reports 2020-01-14 15:26:16
CATCH ME application developed to educate patients as users on their disease and their category of AF with the aim to increase adherence to treatment. Demonstrators, pilots, prototypes 2019-04-18 15:52:57
Launch CATCH ME training programme Demonstrators, pilots, prototypes 2019-04-18 15:52:57
Project website and dissemination material. Websites, patent fillings, videos etc. 2019-04-18 15:52:55
CATCH ME application software designed for smartphones/tablets Demonstrators, pilots, prototypes 2019-04-18 15:52:55

Take a look to the deliverables list in detail:  detailed list of CATCH ME deliverables.


year authors and title journal last update
List of publications.
2018 Martin Manninger, David Zweiker, Arne van Hunnik, Alessio Alogna, Anton J. Prassl, Julia Schipke, Stef Zeemering, Birgit Zirngast, Patrick Schönleitner, Michael Schwarzl, Viktoria Herbst, Eva Thon-Gutschi, Stefan Huber, Ursula Rohrer, Jakob Ebner, Helmut Brussee, Burkert M. Pieske, Frank R. Heinzel, Sander Verheule, Gudrun Antoons, Andreas Lueger, Christian Mühlfeld, Gernot Plank, Ulrich Schotte
Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation
published pages: 1328-1336, ISSN: 1547-5271, DOI: 10.1016/j.hrthm.2018.05.016
Heart Rhythm 15/9 2019-08-05
2018 Piotr Podziemski, Stef Zeemering, Pawel Kuklik, Arne van Hunnik, Bart Maesen, Jos Maessen, Harry J. Crijns, Sander Verheule, Ulrich Schotten
Rotors Detected by Phase Analysis of Filtered, Epicardial Atrial Fibrillation Electrograms Colocalize With Regions of Conduction Block
published pages: , ISSN: 1941-3149, DOI: 10.1161/circep.117.005858
Circulation: Arrhythmia and Electrophysiology 11/10 2019-08-05
2018 Anna Muszkiewicz, Xing Liu, Alfonso Bueno-Orovio, Brodie A. J. Lawson, Kevin Burrage, Barbara Casadei, Blanca Rodriguez
From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study
published pages: H895-H916, ISSN: 0363-6135, DOI: 10.1152/ajpheart.00477.2017
American Journal of Physiology-Heart and Circulatory Physiology 314/5 2019-08-05
2018 Elton A M P Dudink, Frederique E C M Peeters, Sibel Altintas, Luuk I B Heckman, Rutger J Haest, Hans Kragten, Bas L J H Kietselaer, Joachim Wildberger, Justin G L M Luermans, Bob Weijs, Harry J G M Crijns
Agatston score of the descending aorta is independently associated with coronary events in a low-risk population
published pages: e000893, ISSN: 2053-3624, DOI: 10.1136/openhrt-2018-000893
Open Heart 5/2 2019-08-05
2018 Rohan S. Wijesurendra, Alexander Liu, Francesco Notaristefano, Ntobeko A. B. Ntusi, Theodoros D. Karamitsos, Yaver Bashir, Matthew Ginks, Kim Rajappan, Tim R. Betts, Michael Jerosch‐Herold, Vanessa M. Ferreira, Stefan Neubauer, Barbara Casadei
Myocardial Perfusion Is Impaired and Relates to Cardiac Dysfunction in Patients With Atrial Fibrillation Both Before and After Successful Catheter Ablation
published pages: , ISSN: 2047-9980, DOI: 10.1161/jaha.118.009218
Journal of the American Heart Association 7/15 2019-08-05
2018 Renate B Schnabel, Ladislav Pecen, Daniel Engler, Markus Lucerna, Jean Marc Sellal, Francisco M Ojeda, Raffaele De Caterina, Paulus Kirchhof
Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes
published pages: 1608-1614, ISSN: 1355-6037, DOI: 10.1136/heartjnl-2017-312569
Heart 104/19 2019-08-05
2018 Davor Pavlovic, Paulus Kirchhof, Larissa Fabritz
The RACE-3 is on: double-locking sinus rhythm by upstream and downstream therapy
published pages: , ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy018
European Heart Journal 2019-05-16
2017 Arne van Hunnik, Hussein Nasrallah, Dennis H Lau, Marion Kuiper, Sander Verheule, Ulrich Schotten
Vernakalant does not alter early repolarization or contractility in normal and electrically remodelled atria
published pages: 140-148, ISSN: 1099-5129, DOI: 10.1093/europace/eux025
EP Europace 20/1 2019-05-16
2016 Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph Diener, Hein Heidbuchel, Jeroen Hendriks, Gerhard Hindricks, Antonis S. Manolis, Jonas Oldgren, Bogdan Alexandru Popescu, Ulrich Schotten, Bart Van Putte, Panagiotis Vardas, Stefan Agewall, John Camm, Gonzalo Baron Esquivias, Werner Budts, Scipione Carerj, Filip Casselman, Antonio Coca, Raffaele De Caterina, Spiridon Deftereos, Dobromir Dobrev, José M. Ferro, Gerasimos Filippatos, Donna Fitzsimons, Bulent Gorenek, Maxine Guenoun, Stefan H. Hohnloser, Philippe Kolh, Gregory Y. H. Lip, Athanasios Manolis, John McMurray, Piotr Ponikowski, Raphael Rosenhek, Frank Ruschitzka, Irina Savelieva, Sanjay Sharma, Piotr Suwalski, Juan Luis Tamargo, Clare J. Taylor, Isabelle C. Van Gelder, Adriaan A. Voors, Stephan Windecker, Jose Luis Zamorano, Katja Zeppenfeld
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
published pages: 2893-2962, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehw210
European Heart Journal 37/38 2019-05-16
2017 Fahima Syeda, Paulus Kirchhof, Larissa Fabritz
PITX2 -dependent gene regulation in atrial fibrillation and rhythm control
published pages: 4019-4026, ISSN: 0022-3751, DOI: 10.1113/JP273123
The Journal of Physiology 595/12 2019-05-16
2016 Dominik Linz, Mathias Hohl, Stefan Dhein, Sven Ruf, Jan-Christian Reil, Mostafa Kabiri, Paulus Wohlfart, Sander Verheule, Michael Böhm, Thorsten Sadowski, Ulrich Schotten
Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats
published pages: 371-380, ISSN: 0008-6363, DOI: 10.1093/cvr/cvw071
Cardiovascular Research 110/3 2019-05-16
2017 Paulus Kirchhof
Integrated care of patients with atrial fibrillation: the 2016 ESC atrial fibrillation guidelines
published pages: 729-731, ISSN: 1355-6037, DOI: 10.1136/heartjnl-2016-310843
Heart 103/10 2019-05-16
2017 Paulus Kirchhof
The future of atrial fibrillation management: integrated care and stratified therapy
published pages: 1873-1887, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(17)31072-3
The Lancet 390/10105 2019-05-16
2017 Lluís Mont, Eduard Guasch
Atrial fibrillation progression: How sick is the atrium?
published pages: 808-809, ISSN: 1547-5271, DOI: 10.1016/j.hrthm.2017.02.027
Heart Rhythm 14/6 2019-05-16
2017 Stef Zeemering, Theo A.R. Lankveld, Pietro Bonizzi, Ione Limantoro, Sebastiaan C.A.M. Bekkers, Harry J.G.M. Crijns, Ulrich Schotten
The electrocardiogram as a predictor of successful pharmacological cardioversion and progression of atrial fibrillation
published pages: , ISSN: 1099-5129, DOI: 10.1093/europace/eux234
EP Europace 2019-05-16
2017 Dipak Kotecha, Winnie W L Chua, Larissa Fabritz, Jeroen Hendriks, Barbara Casadei, Ulrich Schotten, Panos Vardas, Hein Heidbuchel, Veronica Dean, Paulus Kirchhof
European Society of Cardiology smartphone and tablet applications for patients with atrial fibrillation and their health care providers
published pages: 225-233, ISSN: 1099-5129, DOI: 10.1093/EUROPACE/EUX299
EP Europace 20/2 2019-05-16
2017 Rohan S. Wijesurendra, Barbara Casadei
Seek and Ye Shall Find Subclinical Atrial Fibrillation in High-Risk Elderly Patients
published pages: 1284-1287, ISSN: 0009-7322, DOI: 10.1161/circulationaha.117.029397
Circulation 136/14 2019-05-16
2019 Winnie Chua, Yanish Purmah, Victor R Cardoso, Georgios V Gkoutos, Samantha P Tull, Georgiana Neculau, Mark R Thomas, Dipak Kotecha, Gregory Y H Lip, Paulus Kirchhof, Larissa Fabritz
Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation
published pages: 1268-1276, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy815
European Heart Journal 40/16 2019-08-06
2017 Eduard Guasch, Lluís Mont
Diagnosis, pathophysiology and management of exercise-induced arrhythmias
published pages: 88-101, ISSN: 1759-5002, DOI: 10.1038/nrcardio.2016.173
Nature Reviews Cardiology 14/2 2019-05-16
2017 Ali Gharaviri, Sander Verheule, Jens Eckstein, Mark Potse, Pawel Kuklik, Nico H.L. Kuijpers, Ulrich Schotten
How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation
published pages: euv445, ISSN: 1099-5129, DOI: 10.1093/europace/euv445
Europace 2019-05-16
2016 Eva M. Benito, Alicia Carlosena-Remirez, Eduard Guasch, Susana Prat-González, Rosario J. Perea, Rosa Figueras, Roger Borràs, David Andreu, Elena Arbelo, J. Maria Tolosana, Felipe Bisbal, Josep Brugada, Antonio Berruezo, Lluis Mont
Left atrial fibrosis quantification by late gadolinium-enhanced magnetic resonance: a new method to standardize the thresholds for reproducibility
published pages: 1272-1279, ISSN: 1099-5129, DOI: 10.1093/europace/euw219
EP Europace 19/8 2019-05-16
2016 Fahima Syeda, Andrew P. Holmes, Ting Y. Yu, Samantha Tull, Stefan Michael Kuhlmann, Davor Pavlovic, Daniel Betney, Genna Riley, Jan P. Kucera, Florian Jousset, Joris R. de Groot, Stephan Rohr, Nigel A. Brown, Larissa Fabritz, Paulus Kirchhof
PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers
published pages: 1881-1894, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.07.766
Journal of the American College of Cardiology 68/17 2019-05-24
2016 Paulus Kirchhof, Larissa Fabritz
Can biomarkers balance stroke and bleeding risk?
published pages: 2266-2268, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(16)30121-0
The Lancet 387/10035 2019-05-24
2015 Sebastian Clauss, Moritz F Sinner, Stefan Kääb, Reza Wakili
The Role of MicroRNAs in Antiarrhythmic Therapy for Atrial Fibrillation
published pages: 146, ISSN: 2050-3377, DOI: 10.15420/aer.2015.4.3.146
Arrhythmia & Electrophysiology Review 4/3 2019-05-24
2016 Theo Lankveld, Cees B. de Vos, Ione Limantoro, Stef Zeemering, Elton Dudink, Harry J. Crijns, Ulrich Schotten
Systematic analysis of ECG predictors of sinus rhythm maintenance after electrical cardioversion for persistent atrial fibrillation
published pages: 1020-1027, ISSN: 1547-5271, DOI: 10.1016/j.hrthm.2016.01.004
Heart Rhythm 13/5 2019-05-24
2016 Henri M.H. Spronk, Anne Margreet De Jong, Sander Verheule, Hetty C. De Boer, Alexander H. Maass, Dennis H. Lau, Michiel Rienstra, Arne van Hunnik, Marion Kuiper, Stijn Lumeij, Stef Zeemering, Dominik Linz, Pieter Willem Kamphuisen, Hugo ten Cate, Harry J. Crijns, Isabelle C. Van Gelder, Anton Jan van Zonneveld, Ulrich Schotten
Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation
published pages: ehw119, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehw119
European Heart Journal 2019-05-24
2016 Céline Jumeau, Alain Rupin, Pauline Chieng-Yane, Nathalie Mougenot, Noël Zahr, Monique David-Dufilho, Stéphane N. Hatem
Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
published pages: 328-339, ISSN: 2452-302X, DOI: 10.1016/j.jacbts.2016.05.002
JACC: Basic to Translational Science 1/5 2019-05-24
2016 Sandra Hoffmann, Sebastian Clauss, Ina M. Berger, Birgit Weiß, Antonino Montalbano, Ralph Röth, Madeline Bucher, Ina Klier, Reza Wakili, Hervé Seitz, Eric Schulze-Bahr, Hugo A. Katus, Friederike Flachsbart, Almut Nebel, Sabina PW. Guenther, Erik Bagaev, Wolfgang Rottbauer, Stefan Kääb, Steffen Just, Gudrun A. Rappold
Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation
published pages: , ISSN: 0300-8428, DOI: 10.1007/s00395-016-0557-2
Basic Research in Cardiology 111/3 2019-05-24
2015 Eduard Guasch, Lluís Mont
Exercise, sex and atrial fibrillation: arrhythmogenesis beyond Y-chromosome?
published pages: 1607-1609, ISSN: 1355-6037, DOI: 10.1136/heartjnl-2015-308036
Heart 101/20 2019-05-24
2016 Theo Lankveld, Stef Zeemering, Daniel Scherr, Pawel Kuklik, Boris A. Hoffmann, Stephan Willems, Burkert Pieske, Michel Haïssaguerre, Pierre Jaïs, Harry J. Crijns, Ulrich Schotten
Atrial Fibrillation Complexity Parameters Derived From Surface ECGs Predict Procedural Outcome and Long-Term Follow-Up of Stepwise Catheter Ablation for Atrial Fibrillation
published pages: e003354, ISSN: 1941-3149, DOI: 10.1161/CIRCEP.115.003354
Circulation: Arrhythmia and Electrophysiology 9/2 2019-05-24
2016 U. Schotten, D. Dobrev, P. G. Platonov, H. Kottkamp, G. Hindricks
Current controversies in determining the main mechanisms of atrial fibrillation
published pages: 428-438, ISSN: 0954-6820, DOI: 10.1111/joim.12492
Journal of Internal Medicine 279/5 2019-05-24
2016 Andreas Goette, Jonathan M. Kalman, Luis Aguinaga, Joseph Akar, Jose Angel Cabrera, Shih Ann Chen, Sumeet S. Chugh, Domenico Corradi, Andre D\'Avila, Dobromir Dobrev, Guilherme Fenelon, Mario Gonzalez, Stephane N. Hatem, Robert Helm, Gerhard Hindricks, Siew Yen Ho, Brian Hoit, Jose Jalife, Young-Hoon Kim, Gregory Y.H. Lip, Chang-Sheng Ma, Gregory M. Marcus, Katherine Murray, Akihiko Nogami, Prashanthan Sanders, William Uribe, David Van Wagoner, Stanley Nattel, Osmar A. Centurion, Karl-Heinz Kuck, Kristen K. Patton, John L. Sapp, Martin Stiles, Jesper Hastrup Svendsen, Gaurav A. Upadhyay, Alena Shantsila
EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: definition, characterization, and clinical implication
published pages: euw161, ISSN: 1099-5129, DOI: 10.1093/europace/euw161
Europace 2019-05-24
2016 Andrew P. Holmes, Ting Y. Yu, Samantha Tull, Fahima Syeda, Stefan M. Kuhlmann, Sian-Marie O’Brien, Pushpa Patel, Keith L. Brain, Davor Pavlovic, Nigel A. Brown, Larissa Fabritz, Paulus Kirchhof
A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity
published pages: e0154077, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0154077
PLOS ONE 11/5 2019-05-24
2016 Larissa Fabritz
The power of P in the elderly: Small biphasic wave, big impact
published pages: 652-653, ISSN: 1547-5271, DOI: 10.1016/j.hrthm.2015.11.027
Heart Rhythm 13/3 2019-05-24
2016 Naiara Calvo, Pablo Ramos, Silvia Montserrat, Eduard Guasch, Blanca Coll-Vinent, Mònica Domenech, Felipe Bisbal, Sara Hevia, Silvia Vidorreta, Roger Borras, Carles Falces, Cristina Embid, Josep Maria Montserrat, Antonio Berruezo, Antonio Coca, Marta Sitges, Josep Brugada, Lluís Mont
Emerging risk factors and the dose–response relationship between physical activity and lone atrial fibrillation: a prospective case–control study
published pages: 57-63, ISSN: 1099-5129, DOI: 10.1093/europace/euv216
Europace 18/1 2019-05-24
2016 Paulus Kirchhof, Hugh Calkins
Catheter ablation in patients with persistent atrial fibrillation
published pages: ehw260, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehw260
European Heart Journal 2019-05-24

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