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PHARMS SIGNED

Bacteriophage inhibition of antibiotic-resistant pathogenic microbes and founding for novel therapeutic strategies

Total Cost €

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EC-Contrib. €

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Partnership

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 PHARMS project word cloud

Explore the words cloud of the PHARMS project. It provides you a very rough idea of what is the project "PHARMS" about.

lines    bacteria    isolate    tools    confirmation    modes    delivered    array    synthetic    worldwide    wp2    plan    baumannii    therapeutic    emergence    throughput    resistant    diseases    limited    time    nucleotide    life    unknown    multifaceted    vivo    complement    discover    grand    rational    fight    therapies    culture    host    mediated    pylori    pathogens    obstacles    employ    phages    antibiotics    amr    bactericidal    haemophilus    wp1    alien    mimic    revolutionary    scientific    antimicrobial    discoveries    killed    vitro    action    levels    elucidating    translation    strategies    helicobacter    enzymes    biology    bacterial    wp3    peptides    phage    utilizes    genes    encoded    acinetobacter    driving    group    bacteriophages    treating    resistance    ways    engineer    universal    interdisciplinary    framework    elucidate    molecular    threatening    pharms    natural    transport    validation    vectors    700    multiple    people    battery    sequence    inhibitors    therapy    isolates    discovered    ranging    screen    positioned    mechanisms    independent    infectious    influenzae    inhibition    viruses    deploy    transcription    building    clinical    functions   

Project "PHARMS" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙650 €
 EC max contribution 1˙499˙650 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙499˙650.00

Map

 Project objective

Emergence of antimicrobial resistance (AMR) is a grand scientific challenge of our time that has killed more than 700,000 people worldwide. Phage therapy, a promising complement to antibiotics, utilizes viruses of bacteria (bacteriophages) or phage-derived inhibitors as natural ways to fight AMR. The main obstacles in the clinical application of phage-based AMR therapy are the limited number of phage isolates and the unknown molecular mechanisms of phage-delivered bactericidal action. Building on the recent advances of my group in high-throughput, culture-independent but host-targeted methodologies, PHARMS aims to deploy a revolutionary approach: to screen for all possible phages of a resistant bacterial isolate, characterize multiple lines of their bactericidal functions, and use this information for the design of a whole battery of phage-based therapies that employ multifaceted modes of action.

Using an interdisciplinary research plan, PHARMS will discover phage-specific bactericidal action modes at all possible levels ranging from nucleotide sequence and transcription to translation, in order to elucidate the molecular mechanisms driving phage-mediated inhibition of AMR Acinetobacter baumannii, Helicobacter pylori, & Haemophilus influenzae (WP1). These discoveries, together with novel synthetic biology tools, will enable us to engineer an array of phage vectors that mimic phage-deployed bactericidal modes discovered under WP1, including transport of alien genes to deliver bactericidal effects (WP2). PHARMS will provide molecular confirmation and in vitro & in vivo validation of the functions of phage-encoded bactericidal peptides and enzymes (WP3). By elucidating universal and specific mechanisms of phage-delivered inhibition of AMR pathogens, PHARMS is positioned to provide the rational framework for the design of novel therapeutic strategies aimed at treating common and life-threatening infectious diseases.

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