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BacterialCORE SIGNED

Widespread Bacterial CORE Complex Executes Intra- and Inter-Kingdom Cytoplasmic Molecular Trade

Total Cost €

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EC-Contrib. €

0

Partnership

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 BacterialCORE project word cloud

Explore the words cloud of the BacterialCORE project. It provides you a very rough idea of what is the project "BacterialCORE" about.

transported    anticipate    reveal    larger    bacterial    modulate    species    diseases    crosstalk    describe    inter    data    life    elucidate    communities    function    form    termed    proximal    conserved    colonize    idea    devise    bacteria    ubiquitous    enormous    molecular    combat    preliminary    structure    decipher    niche    facilitates    assembly    cargo    creative    biomass    principles    emsp    protein    global    versatility    foundation    lay    fight    view    earth    flow    herein    module    innovative    machinery    traded    intend    pathogen    virulence    eukaryotic    identification    criteria    organisms    proteins    mediated    components    cells    metabolites    strategies    multicellular    host    acts    core    predict    human    cytoplasmic    unbiased    dominant    pathogenic    kingdom    neighboring    shared    biogenesis    platform    transform    molecules    exchange    apparatuses    rna    membrane    nearly    poorly    physiology    identity    compounds    traffic    specificity    executing    universal    interactions    entire    anti   

Project "BacterialCORE" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 6˙930˙796 €
 EC max contribution 6˙930˙796 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 6˙384˙741.00
2    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) participant 546˙055.00

Map

 Project objective

The enormous versatility of bacteria enables the formation of multi-species communities that colonize nearly every niche on earth, making them the dominant life form and a major component of the biomass. Exchange of molecular information among neighboring bacteria in such communities, as well as between bacteria and proximal eukaryotic cells, is key for bacterial success. Yet, the principles controlling these multicellular interactions are poorly defined. Here we describe the identification of a bacterial protein complex, herein termed CORE, whose function is to traffic cytoplasmic molecules among different bacterial species, and between pathogenic bacteria and their human host cells. The CORE is composed of five membrane proteins, highly conserved across the entire bacterial kingdom, providing a ubiquitous platform that facilitates both intra- and inter-kingdom crosstalk. Our preliminary data support the idea that the CORE acts as a shared module for the assembly of larger apparatuses, executing this universal molecular flow among organisms. We propose to elucidate components, structure and biogenesis of the CORE machinery, operating during bacteria-bacteria and pathogen-host interactions. We further aim to provide an unbiased-global view of the extent and identity of cytoplasmic molecules traded via CORE including metabolites, proteins and RNA, and to reveal the criteria determining the specificity of the transported cargo. Furthermore, we intend to decipher the impact of CORE-mediated molecular exchange on bacterial physiology and virulence, and devise anti-CORE compounds to combat pathogenic bacteria. This study is expected to transform the way we currently view bacterial communities and host-pathogen interactions. We anticipate these findings to lead to the development of creative strategies to modulate, predict and even design bacterial communities, and lay the foundation for new and innovative approaches to fight bacterial diseases.

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The information about "BACTERIALCORE" are provided by the European Opendata Portal: CORDIS opendata.

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