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BacterialCORE SIGNED

Widespread Bacterial CORE Complex Executes Intra- and Inter-Kingdom Cytoplasmic Molecular Trade

Total Cost €

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EC-Contrib. €

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Partnership

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 BacterialCORE project word cloud

Explore the words cloud of the BacterialCORE project. It provides you a very rough idea of what is the project "BacterialCORE" about.

cargo    predict    global    anticipate    facilitates    inter    innovative    module    enormous    apparatuses    membrane    foundation    decipher    entire    fight    diseases    proximal    acts    poorly    biogenesis    idea    interactions    species    bacteria    universal    form    eukaryotic    platform    core    rna    cells    unbiased    versatility    termed    molecules    host    proteins    lay    larger    protein    traded    intend    view    anti    emsp    pathogen    modulate    molecular    niche    function    crosstalk    transported    human    ubiquitous    herein    conserved    data    assembly    structure    organisms    combat    biomass    reveal    metabolites    compounds    earth    executing    describe    transform    communities    creative    specificity    cytoplasmic    kingdom    strategies    pathogenic    machinery    neighboring    virulence    dominant    flow    identification    principles    devise    colonize    traffic    components    multicellular    mediated    physiology    criteria    preliminary    identity    life    nearly    elucidate    bacterial    exchange    shared   

Project "BacterialCORE" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 6˙930˙796 €
 EC max contribution 6˙930˙796 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 6˙384˙741.00
2    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) participant 546˙055.00

Map

 Project objective

The enormous versatility of bacteria enables the formation of multi-species communities that colonize nearly every niche on earth, making them the dominant life form and a major component of the biomass. Exchange of molecular information among neighboring bacteria in such communities, as well as between bacteria and proximal eukaryotic cells, is key for bacterial success. Yet, the principles controlling these multicellular interactions are poorly defined. Here we describe the identification of a bacterial protein complex, herein termed CORE, whose function is to traffic cytoplasmic molecules among different bacterial species, and between pathogenic bacteria and their human host cells. The CORE is composed of five membrane proteins, highly conserved across the entire bacterial kingdom, providing a ubiquitous platform that facilitates both intra- and inter-kingdom crosstalk. Our preliminary data support the idea that the CORE acts as a shared module for the assembly of larger apparatuses, executing this universal molecular flow among organisms. We propose to elucidate components, structure and biogenesis of the CORE machinery, operating during bacteria-bacteria and pathogen-host interactions. We further aim to provide an unbiased-global view of the extent and identity of cytoplasmic molecules traded via CORE including metabolites, proteins and RNA, and to reveal the criteria determining the specificity of the transported cargo. Furthermore, we intend to decipher the impact of CORE-mediated molecular exchange on bacterial physiology and virulence, and devise anti-CORE compounds to combat pathogenic bacteria. This study is expected to transform the way we currently view bacterial communities and host-pathogen interactions. We anticipate these findings to lead to the development of creative strategies to modulate, predict and even design bacterial communities, and lay the foundation for new and innovative approaches to fight bacterial diseases.

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The information about "BACTERIALCORE" are provided by the European Opendata Portal: CORDIS opendata.

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