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ADMAIORA SIGNED

ADvanced nanocomposite MAterIals fOr in situ treatment and ultRAsound-mediated management of osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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ADMAIORA project word cloud

Explore the words cloud of the ADMAIORA project. It provides you a very rough idea of what is the project "ADMAIORA" about.

stimulating materials considerably connection piezoelectric wireless lubrication probes admaiora healthy interventions showed status surgical equipped models cartilage 3d enormous responsivity anti osteoarthritis paradigm cells lifespan degeneration internet active healthcare disease avoiding delivered mechanical billion monitoring tool brace people revolutionize animal quantified euros structures implanted demonstrated evolve replacement innovative total ones physician designed ground elderly stopping joint direct adipose slowing proof biosynthetic burden nanobiomaterial weeks entrapped framework technologies citizens regenerative waves situ million ultrasound months custom oa handheld remote indirect 90 bioprinter hydrogels nanoparticles stem breaking carbon time 60 pain trl arthroscopic autologous preclinical conferring merge inflammatory nanomaterials app things untreated frame respect middle tissue treatment aged patient causes delaying disability experimental

Project "ADMAIORA" data sheet

The following table provides information about the project.

Coordinator	SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA Organization address address: PIAZZA MARTIRI DELLA LIBERTA 33 city: PISA postcode: 56127 website: www.sssup.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	5˙397˙480 €
EC max contribution	5˙397˙480 € (100%)
Programme	1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-TR-IND-2018
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA Organization address address: PIAZZA MARTIRI DELLA LIBERTA 33 city: PISA postcode: 56127 website: www.sssup.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PISA)	coordinator	1˙071˙500.00
2	ISTITUTO ORTOPEDICO RIZZOLI ISTITUTO ORTOPEDICO RIZZOLI Organization address address: VIA DI BARBIANO 1/10 city: BOLOGNA postcode: 40136 website: www.ior.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	1˙112˙500.00
3	IMAGE GUIDED THERAPY SA IMAGE GUIDED THERAPY SA Organization address address: ALLEE DU DOYEN GEORGES BRUS 2 SCIENTIFIQUE UNITEC 1 city: PESSAC postcode: 33600 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PESSAC)	participant	670˙500.00
4	REGENTIS BIOMATERIALS LTD REGENTIS BIOMATERIALS LTD Organization address address: HA ILAN STREET 2 NORTHERN INDUSTRIAL ZONE city: OR AKIVA postcode: 30600 website: www.regentis.co.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (OR AKIVA)	participant	609˙250.00
5	HITECH DEVELOPMENT WIRELESS SWEDENAB HITECH DEVELOPMENT WIRELESS SWEDENAB Organization address address: FAROGATAN 33 VPL 44 city: KISTA postcode: 16451 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (KISTA)	participant	576˙930.00
6	BAR ILAN UNIVERSITY BAR ILAN UNIVERSITY Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 website: www.biu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (RAMAT GAN)	participant	524˙800.00
7	VIMEX SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA VIMEX SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA Organization address address: TORUNSKA 27 city: GLIWICE postcode: 44 122 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (GLIWICE)	participant	506˙375.00
8	PLASMACHEM PRODUKTIONS- UND HANDEL GMBH PLASMACHEM PRODUKTIONS- UND HANDEL GMBH Organization address address: SCHWARZSCHILDSTRASSE 10 city: BERLIN postcode: 12489 website: http://www.plasmachem.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	325˙625.00

Map

Project objective

Osteoarthritis (OA) is a major burden that affects ~ 40 million of EU citizens, with enormous direct and indirect costs for the European healthcare systems, quantified in ~ 50.4 billion euros per year. This disease involves the degeneration of cartilage and other joint structures and is one of the most common causes of pain and disability in middle-aged and elderly people. ADMAIORA aims in the long-term at increasing the healthy and active lifespan of people affected by OA, by considerably slowing down or even stopping the degeneration process, thus delaying or avoiding surgical interventions for total joint replacement. Within the project time-frame the target is to achieve a 60% reduction of degeneration in OA animal models treated with the ADMAIORA technologies, with respect to control (untreated) ones, after 4 weeks, and a 90% reduction after 3 months. To achieve this ambitious objective the Consortium will evolve and merge technologies that already showed a high potential as experimental proof of concepts (TRL = 3) and will bring them at a preclinical level (TRL = 5). The ADMAIORA Consortium will develop biosynthetic hydrogels embedded with carbon-based nanomaterials, conferring higher mechanical and lubrication properties, and piezoelectric nanoparticles enabling responsivity to remote wireless ultrasound waves. Stem cells derived from autologous adipose tissue, which already demonstrated anti-inflammatory and regenerative properties, will be entrapped in the hydrogels. Materials and cells will be delivered in situ through an innovative handheld 3D bioprinter, embedded in an arthroscopic tool. A custom brace will be designed and equipped with ultrasound probes for both monitoring the joint status and stimulating the implanted piezoelectric nanobiomaterial. A dedicated App will allow a direct connection between patient and physician in an Internet of Things framework. Overall, ADMAIORA will target a ground-breaking paradigm that may revolutionize OA treatment.

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The information about "ADMAIORA" are provided by the European Opendata Portal: CORDIS opendata.

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