ADMAIORA SIGNED
ADvanced nanocomposite MAterIals fOr in situ treatment and ultRAsound-mediated management of osteoarthritis
Total Cost €
0EC-Contrib. €
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ADMAIORA project word cloud
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Project "ADMAIORA" data sheet
The following table provides information about the project.
| Coordinator |
SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 5˙397˙480 € |
| EC max contribution | 5˙397˙480 € (100%) |
| Programme |
1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies) |
| Code Call | H2020-NMBP-TR-IND-2018 |
| Funding Scheme | RIA |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-01-01 to 2023-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA | IT (PISA) | coordinator | 1˙071˙500.00 |
| 2 | ISTITUTO ORTOPEDICO RIZZOLI | IT (BOLOGNA) | participant | 1˙112˙500.00 |
| 3 | IMAGE GUIDED THERAPY SA | FR (PESSAC) | participant | 670˙500.00 |
| 4 | REGENTIS BIOMATERIALS LTD | IL (OR AKIVA) | participant | 609˙250.00 |
| 5 | HITECH DEVELOPMENT WIRELESS SWEDENAB | SE (KISTA) | participant | 576˙930.00 |
| 6 | BAR ILAN UNIVERSITY | IL (RAMAT GAN) | participant | 524˙800.00 |
| 7 | VIMEX SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA | PL (GLIWICE) | participant | 506˙375.00 |
| 8 | PLASMACHEM PRODUKTIONS- UND HANDEL GMBH | DE (BERLIN) | participant | 325˙625.00 |
Map
Project objective
Osteoarthritis (OA) is a major burden that affects ~ 40 million of EU citizens, with enormous direct and indirect costs for the European healthcare systems, quantified in ~ 50.4 billion euros per year. This disease involves the degeneration of cartilage and other joint structures and is one of the most common causes of pain and disability in middle-aged and elderly people. ADMAIORA aims in the long-term at increasing the healthy and active lifespan of people affected by OA, by considerably slowing down or even stopping the degeneration process, thus delaying or avoiding surgical interventions for total joint replacement. Within the project time-frame the target is to achieve a 60% reduction of degeneration in OA animal models treated with the ADMAIORA technologies, with respect to control (untreated) ones, after 4 weeks, and a 90% reduction after 3 months. To achieve this ambitious objective the Consortium will evolve and merge technologies that already showed a high potential as experimental proof of concepts (TRL = 3) and will bring them at a preclinical level (TRL = 5). The ADMAIORA Consortium will develop biosynthetic hydrogels embedded with carbon-based nanomaterials, conferring higher mechanical and lubrication properties, and piezoelectric nanoparticles enabling responsivity to remote wireless ultrasound waves. Stem cells derived from autologous adipose tissue, which already demonstrated anti-inflammatory and regenerative properties, will be entrapped in the hydrogels. Materials and cells will be delivered in situ through an innovative handheld 3D bioprinter, embedded in an arthroscopic tool. A custom brace will be designed and equipped with ultrasound probes for both monitoring the joint status and stimulating the implanted piezoelectric nanobiomaterial. A dedicated App will allow a direct connection between patient and physician in an Internet of Things framework. Overall, ADMAIORA will target a ground-breaking paradigm that may revolutionize OA treatment.
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