Opendata, web and dolomites


Suppression of Organelle Defects in Human Disease

Total Cost €


EC-Contrib. €






 SOLID project word cloud

Explore the words cloud of the SOLID project. It provides you a very rough idea of what is the project "SOLID" about.

difficulty    reveal    suppressors    paradigm    fitness    organelle    instead    captures    perturbed    altogether    haploid    cell    impaired    biology    applicable    disorders    gene    initial    view    neurodegeneration    suppression    combines    diversity    concerted    disease    genetic    biological    modules    defects    causative    limited    perturbation    fashion    centric    machines    mutation    alongside    time    departs    incurable    correct    function    yeast    hidden    surveys    eukaryotic    organelles    solid    mutagenesis    fixed    hurdles    lysosomes    stratification    drugging    questions    platform    groundbreaking    mostly    phenotypes    environmental    fidelity    functioning    organisms    frustrations    point    entirely    query    extensive    cures    independent    genome    recessive    revealing    relies    human    therapeutic    engineering    first    mutations    uncover    absent    lacking    model    cellular    suppressor    uniquely    metabolic    ultradeep    substantial    strategies    malfunctioning    exemplified    create    until    exhaustive    contain    systematic    amount    diseases    mainly    alter    mapping    direct    genetics    mutants    hundreds    urgently    possibilities    mitochondria    genes    yielding    etiological    interrogate    triggers    remove   

Project "SOLID" data sheet

The following table provides information about the project.


Organization address
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙400 €
 EC max contribution 1˙498˙400 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The goal of SOLID is the systematic mapping of genetic suppression for important organelles with impaired fidelity in human disease to uncover new strategies to correct the perturbed state. Functioning of the eukaryotic cell relies on the concerted activity of biological machines, defects in which can cause incurable human disease, including metabolic disorders and neurodegeneration. This is exemplified by malfunctioning mitochondria or lysosomes, for which (alongside environmental triggers) hundreds of causative genes have been identified, but cures are mostly lacking. This is mainly due to the difficulty of drugging loss-of-function mutations, which uniquely alter or entirely remove the gene product. Extensive studies in yeast and initial work in the human system show that cellular modules contain a substantial amount of hidden genetic suppression. Revealing suppressors of disease-defining features of organelle perturbation and targeting those instead of the query mutations, will address the frustrations of drugging an absent factor and etiological diversity. Until now, mutation-based genome-wide suppressor surveys were mostly limited to model organisms and phenotypes yielding growth defects, due to technical hurdles associated with recessive genetics in the human system. However, with the development of a groundbreaking new forward genetics platform that combines genome engineering, ultradeep haploid mutagenesis and direct stratification of fixed mutants, we can now, for the first time, interrogate genetic suppression of human organelle defects independent of cellular fitness. SOLID will also develop new technology to study organelle fidelity in an exhaustive fashion that departs from a gene-centric view point and captures complex phenotypes. Altogether, this will create a new paradigm of 'studying cell biology via genetics' widely applicable to many different biological questions, and reveal urgently needed novel therapeutic possibilities for incurable diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SOLID" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SOLID" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PSYDISC (2020)

Developing and Testing the Psychological Distance to Science Model

Read More  

ImmUne (2019)

Towards identification of the unifying principles of vertebrate adaptive immunity

Read More  

EffectiveTG (2018)

Effective Methods in Tame Geometry and Applications in Arithmetic and Dynamics

Read More