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KryptonInt SIGNED

Erasing the superintegron to understand the role of chromosomal integrons in bacterial evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 KryptonInt project word cloud

Explore the words cloud of the KryptonInt project. It provides you a very rough idea of what is the project "KryptonInt" about.

located    circulation    elucidate    tool    17    gene    mobility    chromosomal    giving    paradoxical    extremely    precludes    hundreds    power    disease    mobile    integron    cholerae    humans    i3c    exapted    context    model    chromosomes    medicine    proof    caused    encoded    history    mi    functions    good    agent    adaptive    excellent    scis    cholera    bacteria    association    vibrio    understand    interferes    paradigm    unravel    126    plasmids    sci    genesis    nature    acquisition    seqdelta    acquired    causative    native    environmental    inaccessible    biosynthetic    pathogens    background    genes    class    antitoxin    preliminary    chromosome    stabilized    evolution    adaptability    bacterial    named    historically    integrons    experimental    toxin    module    platforms    situation    antibiotic    superintegron    little    found    modern    sedentary    unexpected    multidrug    fundamental    size    stockpiling    evolvability    despite    cassettes    environment    eons    transposons    deadliest    animals    si    food    explore    threat    genetic    deleting    resistance    poorly    performed    kb    kryptonint    conjugative    functional   

Project "KryptonInt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙499˙516 €
 EC max contribution 1˙499˙516 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 1˙499˙516.00

Map

 Project objective

Integrons are genetic platforms that enhance bacterial evolvability through the acquisition and stockpiling of new genes encoded in mobile elements named cassettes. They are found in the chromosomes of environmental bacteria but some have acquired mobility through their association to transposons and conjugative plasmids. These mobile integrons (MI) caused the unexpected rise of multidrug resistance that is now a major threat to modern medicine, and are good proof of the adaptive power of integrons. Class 1 integrons are the most relevant MI and the major experimental model. Yet little is known about the hundreds of sedentary chromosomal integrons (SCI) that have driven bacterial evolution for eons. The paradigm of SCI is the superintegron (SI), an extremely large integron located in the chromosome of Vibrio cholerae, the causative agent of Cholera disease. Despite its role in the adaptability of one of the deadliest pathogens in history, the SI is poorly characterized because it is only functional in its native genetic background, yet its presence interferes with, and precludes all studies performed in V. cholerae. I propose to solve this paradoxical situation by deleting the SI, an ambitious project not only for its size (126 Kb) but because it is highly stabilized by 17 toxin-antitoxin systems. To do so, I have developed SeqDelTA, a novel method that is already giving excellent preliminary results. I will then use V. cholerae∆SI to study fundamental aspects of SCIs, yet out of reach. I will elucidate the functions encoded in SI cassettes to understand the role and adaptive value of integrons in nature; I will also unravel the genesis of cassettes: how a gene is exapted from its genetic context to become a mobile module; and I will explore the circulation of antibiotic resistance cassettes among humans, animals, food, and the environment with a novel biosynthetic tool (the I3C). KryptonInt will open and explore the historically inaccessible field of study of SCIs.

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