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KryptonInt SIGNED

Erasing the superintegron to understand the role of chromosomal integrons in bacterial evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 KryptonInt project word cloud

Explore the words cloud of the KryptonInt project. It provides you a very rough idea of what is the project "KryptonInt" about.

situation    genetic    genesis    platforms    causative    precludes    explore    mobility    scis    background    class    preliminary    model    seqdelta    fundamental    nature    toxin    superintegron    evolvability    disease    genes    stabilized    history    chromosomes    sedentary    i3c    conjugative    mobile    evolution    deadliest    environment    hundreds    adaptability    elucidate    paradoxical    eons    paradigm    antibiotic    multidrug    functions    adaptive    good    mi    experimental    proof    bacterial    cholerae    cholera    kryptonint    exapted    extremely    giving    functional    integron    transposons    poorly    integrons    little    encoded    modern    excellent    animals    size    gene    sci    medicine    chromosomal    inaccessible    chromosome    plasmids    antitoxin    historically    food    module    circulation    despite    interferes    named    found    126    biosynthetic    context    acquired    tool    si    association    environmental    performed    bacteria    kb    unexpected    vibrio    resistance    stockpiling    17    located    deleting    unravel    acquisition    agent    humans    power    caused    understand    threat    native    cassettes    pathogens   

Project "KryptonInt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙499˙516 €
 EC max contribution 1˙499˙516 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 1˙499˙516.00

Map

 Project objective

Integrons are genetic platforms that enhance bacterial evolvability through the acquisition and stockpiling of new genes encoded in mobile elements named cassettes. They are found in the chromosomes of environmental bacteria but some have acquired mobility through their association to transposons and conjugative plasmids. These mobile integrons (MI) caused the unexpected rise of multidrug resistance that is now a major threat to modern medicine, and are good proof of the adaptive power of integrons. Class 1 integrons are the most relevant MI and the major experimental model. Yet little is known about the hundreds of sedentary chromosomal integrons (SCI) that have driven bacterial evolution for eons. The paradigm of SCI is the superintegron (SI), an extremely large integron located in the chromosome of Vibrio cholerae, the causative agent of Cholera disease. Despite its role in the adaptability of one of the deadliest pathogens in history, the SI is poorly characterized because it is only functional in its native genetic background, yet its presence interferes with, and precludes all studies performed in V. cholerae. I propose to solve this paradoxical situation by deleting the SI, an ambitious project not only for its size (126 Kb) but because it is highly stabilized by 17 toxin-antitoxin systems. To do so, I have developed SeqDelTA, a novel method that is already giving excellent preliminary results. I will then use V. cholerae∆SI to study fundamental aspects of SCIs, yet out of reach. I will elucidate the functions encoded in SI cassettes to understand the role and adaptive value of integrons in nature; I will also unravel the genesis of cassettes: how a gene is exapted from its genetic context to become a mobile module; and I will explore the circulation of antibiotic resistance cassettes among humans, animals, food, and the environment with a novel biosynthetic tool (the I3C). KryptonInt will open and explore the historically inaccessible field of study of SCIs.

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The information about "KRYPTONINT" are provided by the European Opendata Portal: CORDIS opendata.

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