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KryptonInt SIGNED

Erasing the superintegron to understand the role of chromosomal integrons in bacterial evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 KryptonInt project word cloud

Explore the words cloud of the KryptonInt project. It provides you a very rough idea of what is the project "KryptonInt" about.

genesis    integrons    biosynthetic    antitoxin    located    stabilized    genes    class    model    fundamental    nature    vibrio    antibiotic    17    context    mi    toxin    modern    functions    disease    sedentary    pathogens    unravel    experimental    excellent    transposons    food    situation    plasmids    mobility    seqdelta    caused    threat    eons    preliminary    exapted    elucidate    integron    power    encoded    mobile    kb    stockpiling    bacterial    chromosomes    si    size    superintegron    bacteria    found    gene    acquired    good    chromosomal    deadliest    extremely    hundreds    scis    sci    deleting    chromosome    interferes    native    126    medicine    cholerae    kryptonint    agent    resistance    multidrug    circulation    named    evolvability    genetic    association    little    historically    causative    despite    paradigm    acquisition    module    environmental    cholera    functional    platforms    precludes    unexpected    adaptability    cassettes    inaccessible    understand    explore    giving    adaptive    animals    evolution    tool    background    proof    conjugative    performed    history    environment    humans    i3c    paradoxical    poorly   

Project "KryptonInt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙499˙516 €
 EC max contribution 1˙499˙516 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 1˙499˙516.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Integrons are genetic platforms that enhance bacterial evolvability through the acquisition and stockpiling of new genes encoded in mobile elements named cassettes. They are found in the chromosomes of environmental bacteria but some have acquired mobility through their association to transposons and conjugative plasmids. These mobile integrons (MI) caused the unexpected rise of multidrug resistance that is now a major threat to modern medicine, and are good proof of the adaptive power of integrons. Class 1 integrons are the most relevant MI and the major experimental model. Yet little is known about the hundreds of sedentary chromosomal integrons (SCI) that have driven bacterial evolution for eons. The paradigm of SCI is the superintegron (SI), an extremely large integron located in the chromosome of Vibrio cholerae, the causative agent of Cholera disease. Despite its role in the adaptability of one of the deadliest pathogens in history, the SI is poorly characterized because it is only functional in its native genetic background, yet its presence interferes with, and precludes all studies performed in V. cholerae. I propose to solve this paradoxical situation by deleting the SI, an ambitious project not only for its size (126 Kb) but because it is highly stabilized by 17 toxin-antitoxin systems. To do so, I have developed SeqDelTA, a novel method that is already giving excellent preliminary results. I will then use V. cholerae∆SI to study fundamental aspects of SCIs, yet out of reach. I will elucidate the functions encoded in SI cassettes to understand the role and adaptive value of integrons in nature; I will also unravel the genesis of cassettes: how a gene is exapted from its genetic context to become a mobile module; and I will explore the circulation of antibiotic resistance cassettes among humans, animals, food, and the environment with a novel biosynthetic tool (the I3C). KryptonInt will open and explore the historically inaccessible field of study of SCIs.

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The information about "KRYPTONINT" are provided by the European Opendata Portal: CORDIS opendata.

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