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FREIA SIGNED

Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FREIA" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 6˙104˙476 €
 EC max contribution 6˙104˙476 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 1˙529˙108.00
2    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 1˙025˙796.00
3    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) participant 783˙130.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 493˙750.00
5    UNIVERSITE DE LIEGE BE (LIEGE) participant 463˙843.00
6    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 456˙387.00
7    THE QUEEN'S UNIVERSITY OF BELFAST UK (BELFAST) participant 398˙915.00
8    TERVISETEHNOLOOGIATE ARENDUSKESKUS AS EE (TARTU) participant 311˙375.00
9    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 239˙481.00
10    TRUSTEES OF TUFTS COLLEGE CORPORATION US (MEDFORD MA) participant 201˙740.00
11    UPPSALA UNIVERSITET SE (UPPSALA) participant 200˙948.00

Map

 Project objective

The FREIA consortium aims to close gaps in scientific knowledge on the mechanisms by which EDCs can affect female reproduction during specific life stages and will provide test methods to address this. The FREIA consortium has human tissue models that span the entire life cycle from fetal ovarian and adrenal tissues to child and mature ovarian follicles, that will be used identify human relevant biomarkers of EDC exposure. We will measure chemical exposures in follicular fluids and molecular profiles in granulosa cells from two IVF cohorts, and link these to fertility outcomes and patient journal information, including life-style factors and workplace. We will perform in vivo rodent studies to capture susceptible windows of exposure and identify novel endpoints for female reproductive toxicity that may be implemented in OECD test guidelines. We will provide in vitro test methods, according to OECD guidelines, for molecular and cellular events that have been implicated in female reproductive toxicity. These include ER-beta activity, GPER activity, ovarian-specific steroidogenesis, oocyte maturation and competency and hypothalamic pulsatile GnRH secretion. We will also develop QSAR models to predict interaction with aromatase and PPAR-gamma. By integrating our data from in vitro studies with primary human tissues, human exposure data from fetal and follicular fluid samples and our in vitro and in vivo research findings, the outcomes of FREIA are directly applicable to the human situation. AOPs will be developed that will form the basis for a test strategy to assess female reproductive toxicity upon exposure to EDCs, in a regulatory context. Furthermore, by expanding our scientific knowledge, the FREIA project will provide better information on EDC-related female reproductive health effects that will be used to improve reproductive health for women around the world.

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The information about "FREIA" are provided by the European Opendata Portal: CORDIS opendata.

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