Explore the words cloud of the ViroPedTher project. It provides you a very rough idea of what is the project "ViroPedTher" about.
The following table provides information about the project.
UNIVERSIDAD DE NAVARRA
|Coordinator Country||Spain [ES]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2019-03-01 to 2024-02-29|
Take a look of project's partnership.
|1||UNIVERSIDAD DE NAVARRA||ES (PAMPLONA)||coordinator||2˙000˙000.00|
The overreaching goal of my lab is to improve the prognosis of patients with high-risk pediatric brain tumors. To this end, I propose to integrate clinical and lab-based research to develop tumor-targeted oncolytic adenoviruses with the capacity to elicit a therapeutic immune response in those tumors. Our research will use novel and relevant models to accomplish the experimental aims. We have previously worked with Delta-24-RGD (DNX-2401) a replication-competent adenovirus that has been translated to the clinical scenario. In 2017, the first clinical trial phase I with DNX-2401 for newly diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG; a lethal pediatric brain tumor) opened propelled by my team. Preliminary results from the first trials revealed that the intratumoral injection of the virus instigated an initial phase of oncolysis followed by a delayed inflammatory response that ultimately resulted in complete regression in a subset of the patients without associated toxicities. I hypothesized that enhancement of the immune component of the DNX-2401-based therapy will result in the complete regression of the vast majority of pediatric brain tumors. In our specific approach, we propose to understand the immune microenvironment of DIPGs and the response to viral therapy in the context of the trial. Moreover, that knowledge will leverage the design of Delta-24-based adenoviruses to recruit lymphocytes to the tumor with the competence of different type of ligands to activate the tumor infiltrating lymphocytes. I expect that this combinatorial innovative treatment will efficiently challenge the profound and inherent tumor immunosuppression and, in turn, will elicit a robust anti-tumor immune response resulting in the significant improvement of the prognosis and quality of life of patients with pediatric brain tumors. This project has the potential to produce a vertical advance in the field of pediatric oncology.
|year||authors and title||journal||last update|
Naiara MartÃnez-VÃ©lez, Marc Garcia-Moure, Miguel Marigil, Marisol GonzÃ¡lez-Huarriz, Montse Puigdelloses, Jaime Gallego PÃ©rez-Larraya, Marta ZalacaÃn, LucÃa MarrodÃ¡n, Maider Varela-Guruceaga, Virginia Laspidea, Jose Javier Aristu, Luis Isaac Ramos, Sonia Tejada-SolÃs, Ricardo DÃez-Valle, Chris Jones, Alan Mackay, Jose A. MartÃnez-Climent, Maria Jose GarcÃa-Barchino, Eric Raabe, Michelle
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10043-0
|Nature Communications 10/1||2020-02-05|
Ignacio IÃ±igo-Marco, Marta M. Alonso
Destress and do not suppress: targeting adrenergic signaling in tumor immunosuppression
published pages: 5086-5088, ISSN: 0021-9738, DOI: 10.1172/jci133115
|Journal of Clinical Investigation 129/12||2020-02-05|
Donatas StakiÅ¡aitis, Milda JukneviÄienÄ—, Eligija DamanskienÄ—, Angelija ValanÄiÅ«tÄ—, Ingrida BalnytÄ—, Marta Maria Alonso
The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo
published pages: 1210, ISSN: 2072-6694, DOI: 10.3390/cancers11081210
Naiara Martinez-Velez, Miguel Marigil, Marc GarcÃa-Moure, Marisol Gonzalez-Huarriz, Jose Javier Aristu, Luis-Isaac Ramos-GarcÃa, Sonia Tejada, Ricardo DÃez-Valle, Ana PatiÃ±o-GarcÃa, Oren J. Becher, Candelaria Gomez-Manzano, Juan Fueyo, Marta M. Alonso
Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-019-0714-6
|Acta Neuropathologica Communications 7/1||2020-02-05|
Marc Garcia-Moure, Naiara Martinez-Velez, Marisol Gonzalez-Huarriz, LucÃa MarrodÃ¡n, Manel Cascallo, RamÃ³n Alemany, Ana PatiÃ±o-GarcÃa, Marta M. Alonso
The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-51014-1
|Scientific Reports 9/1||2020-02-05|
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The information about "VIROPEDTHER" are provided by the European Opendata Portal: CORDIS opendata.
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