Opendata, web and dolomites

ScarLessWorld SIGNED

A WORLD WITHOUT SCARS: Regenerating wounded skin rather than patching with scars

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ScarLessWorld project word cloud

Explore the words cloud of the ScarLessWorld project. It provides you a very rough idea of what is the project "ScarLessWorld" about.

building    prevention    locations    mystery    unresolved    imaging    gene    environment    biomedical    types    drive    skin    complete    avenues    hypothesis    natural    rarely    modification    gender    humans    mammals    decision    norm    full    bottleneck    human    experiments    clinical    depends    notion    uncovering    phenotypes    regeneration    regenerative    internal    technological    damaged    breakthroughs    tissues    expertise    age    connective    compositions    lineages    innovative    scar    linchpins    theory    vertebrates    showing    had    challenged    resolve    live    assays    repertoires    mouse    tracking    specialized    injured    dynamics    display    lies    anywhere    genes    animal    frequent    regenerate    dermal    translate    anatomic    fibroblast    image    rare    fibroblasts    scarring    organ    injury    conceptual    lack    scars    actual    lower    complexity    bottlenecks    worldwide    diversity    catalogue    medicine    cell    anytime    species    combined    tools   

Project "ScarLessWorld" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙890 €
 EC max contribution 1˙997˙890 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙997˙890.00

Map

 Project objective

Scars are a mystery. They rarely develop in lower vertebrates, where the norm is a complete regeneration of damaged tissues, but are frequent in mammals including humans. Scar phenotypes depend on different injury types, anatomic locations, age, gender and species. The natural diversity of scars includes rare cases, where damaged tissues regenerate without scarring. The scar/regeneration decision remains unresolved and scar prevention is a clinical challenge. Current research has been held up by conceptual and operational bottlenecks. The current conceptual notion comes from experiments showing that scarring depends on the internal environment of the injured organ. I challenged this notion by uncovering specialized fibroblast cell lineages that regenerate connective tissues without scars, anywhere, anytime. My hypothesis is that the decision to scar/regenerate lies in the compositions of specific fibroblast types. To further study this theory I had to resolve a second bottleneck, the current lack of assays that display the full complexity of scarring and regeneration. I have thus developed innovative technological approaches (four novel tools) that allow whole-animal live imaging, tracking and gene modification of fibroblasts. Building on these innovative tools and my expertise in cell lineages as linchpins of this proposal, I aim to: (1) catalogue the repertoires of dermal fibroblast lineages, (2) image their dynamics during scarring/regeneration (3) identify the decision-making genes for scarring/regeneration in actual skin tissues, and finally (4) translate our findings from mouse to human skin. This new notion that specialized fibroblast lineages drive scarring/regeneration, combined with the technology breakthroughs, will greatly advance our current understanding of scar formation, which is a significant worldwide biomedical problem, creating new research avenues for regenerative medicine far beyond the current state-of-the-art.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SCARLESSWORLD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SCARLESSWORLD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More  

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More