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ScarLessWorld SIGNED

A WORLD WITHOUT SCARS: Regenerating wounded skin rather than patching with scars

Total Cost €

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EC-Contrib. €

0

Partnership

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 ScarLessWorld project word cloud

Explore the words cloud of the ScarLessWorld project. It provides you a very rough idea of what is the project "ScarLessWorld" about.

vertebrates    tissues    scarring    clinical    natural    injury    imaging    challenged    complexity    experiments    breakthroughs    animal    complete    fibroblasts    resolve    rare    compositions    gene    expertise    dynamics    theory    lies    cell    species    genes    bottleneck    decision    medicine    worldwide    frequent    lower    linchpins    mouse    specialized    scars    phenotypes    bottlenecks    full    image    innovative    internal    repertoires    actual    regenerative    hypothesis    catalogue    drive    rarely    depends    display    skin    injured    lineages    humans    notion    unresolved    prevention    translate    anatomic    human    dermal    connective    organ    anytime    had    lack    anywhere    avenues    technological    types    fibroblast    tracking    building    showing    live    scar    biomedical    tools    locations    regenerate    norm    environment    conceptual    mammals    gender    regeneration    age    uncovering    mystery    diversity    modification    damaged    assays    combined   

Project "ScarLessWorld" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙890 €
 EC max contribution 1˙997˙890 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙997˙890.00

Map

 Project objective

Scars are a mystery. They rarely develop in lower vertebrates, where the norm is a complete regeneration of damaged tissues, but are frequent in mammals including humans. Scar phenotypes depend on different injury types, anatomic locations, age, gender and species. The natural diversity of scars includes rare cases, where damaged tissues regenerate without scarring. The scar/regeneration decision remains unresolved and scar prevention is a clinical challenge. Current research has been held up by conceptual and operational bottlenecks. The current conceptual notion comes from experiments showing that scarring depends on the internal environment of the injured organ. I challenged this notion by uncovering specialized fibroblast cell lineages that regenerate connective tissues without scars, anywhere, anytime. My hypothesis is that the decision to scar/regenerate lies in the compositions of specific fibroblast types. To further study this theory I had to resolve a second bottleneck, the current lack of assays that display the full complexity of scarring and regeneration. I have thus developed innovative technological approaches (four novel tools) that allow whole-animal live imaging, tracking and gene modification of fibroblasts. Building on these innovative tools and my expertise in cell lineages as linchpins of this proposal, I aim to: (1) catalogue the repertoires of dermal fibroblast lineages, (2) image their dynamics during scarring/regeneration (3) identify the decision-making genes for scarring/regeneration in actual skin tissues, and finally (4) translate our findings from mouse to human skin. This new notion that specialized fibroblast lineages drive scarring/regeneration, combined with the technology breakthroughs, will greatly advance our current understanding of scar formation, which is a significant worldwide biomedical problem, creating new research avenues for regenerative medicine far beyond the current state-of-the-art.

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The information about "SCARLESSWORLD" are provided by the European Opendata Portal: CORDIS opendata.

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