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Improvement of food safety applied biosensors by protein engineering

Total Cost €


EC-Contrib. €






 BIOIMPROVE project word cloud

Explore the words cloud of the BIOIMPROVE project. It provides you a very rough idea of what is the project "BIOIMPROVE" about.

academy    quality    poisoning    paramount    thanks    guaranteeing    scombroid    maximize    protein    enzyme    materials    powerful    bioimprove    portable    content    detecting    strategy    biolan    cic    gaining    biogune    she    microbiosensores    tools    stages    prevent    susceptible    contamination    centre    molecules    tandem    structural    detect    career    lower    safety    spanish    computational    determination    freshness    expertise    mg    engineering    gangoiti    conduct    generation    allergy    reputation    sensitivity    libraries    concentration    sensitive    carry    environment    lt    monitoring    innovative    fish    hotspots    semi    consumers    chain    hazardous    complementary    performed    biosensor    sme    health    successful    pursuing    ultimately    rational    competences    industry    food    careful    either    mutational    screening    multidisciplinary    biosensors    dr    histamine    biosensing    secondment    raw    device    hygienic    opportunity    quantification   

Project "BIOIMPROVE" data sheet

The following table provides information about the project.


Organization address
postcode: 48170
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-08-18


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOLAN MICROBIOSENSORES SL ES (ZAMUDIO) coordinator 172˙932.00


 Project objective

Determination of the histamine content is of paramount importance for the food industry as a parameter of the hygienic quality and freshness of food, as well as to prevent scombroid fish poisoning, an allergy-like food poisoning. At present, more sensitive and user-friendly methods for histamine monitoring are needed to early detect products and raw materials susceptible of becoming hazardous for consumers. BIOIMPROVE aims to develop an improved and highly sensitive portable biosensing device for the quantification of histamine in the lower concentration range (<5 mg/l). To reach this objective, an innovative and powerful semi-rational protein engineering strategy will be used to maximize the sensitivity of the currently available histamine enzyme-based biosensor. Rather than addressing this goal by the generation and screening of large libraries, a careful selection of the most promising mutational hotspots will be performed using the structural available information in tandem with advanced computational modelling tools. Dr. Gangoiti will carry out BIOIMPROVE project at BIOLAN Microbiosensores, a Spanish SME focused on the development of biosensors capable of detecting health and food-related molecules. To support her research, she will conduct a secondment at CIC bioGUNE, a research centre that has a strong reputation in protein computational design. Thanks to this multidisciplinary research environment, Dr. Gangoiti will have the opportunity of gaining not only a high level of complementary expertise in areas of key importance in the enzyme technology field, but also the competences required for pursuing a successful research career either in industry or academy. Most importantly, the implementation of BIOIMPROVE project is expected to ensure histamine contamination to be identified at all stages of the food chain, ultimately guaranteeing food safety for European consumers.

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The information about "BIOIMPROVE" are provided by the European Opendata Portal: CORDIS opendata.

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