MARK-AGE

European Study to Establish Biomarkers of Human Ageing

 Coordinatore UNIVERSITAT KONSTANZ 

 Organization address address: UNIVERSITATSSTRASSE 10
city: KONSTANZ
postcode: 78457

contact info
Titolo: Ms.
Nome: Gertraud
Cognome: Plaza-Pascual
Email: send email
Telefono: -7531882723
Fax: -7531883678

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.mark-age.eu/
 Totale costo 15˙907˙409 €
 EC contributo 11˙989˙327 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2013-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAT KONSTANZ

 Organization address address: UNIVERSITATSSTRASSE 10
city: KONSTANZ
postcode: 78457

contact info
Titolo: Ms.
Nome: Gertraud
Cognome: Plaza-Pascual
Email: send email
Telefono: -7531882723
Fax: -7531883678

DE (KONSTANZ) coordinator 0.00
2    AARHUS UNIVERSITET

 Organization address address: Nordre Ringgade 1
city: AARHUS C
postcode: 8000

contact info
Titolo: Ms.
Nome: Helle
Cognome: Alstrup
Email: send email
Telefono: -89425013
Fax: -6123141

DK (AARHUS C) participant 0.00
3    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Ms.
Nome: Karin
Cognome: Wibier
Email: send email
Telefono: +31 71 526 9568
Fax: +31 71 526 8275

NL (LEIDEN) participant 0.00
4    ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA

 Organization address address: Via Zamboni 33
city: BOLOGNA
postcode: 40126

contact info
Titolo: Dr.
Nome: Andrea
Cognome: Previti
Email: send email
Telefono: +39 051 209 4766
Fax: +039 051 2094768

IT (BOLOGNA) participant 0.00
5    ANA ASLAN INSTITUTE OF GERONTOLOGY AND GERIATRICS

 Organization address address: STRADA MANASTIREA CALDARUSANI 9
city: BUCHAREST
postcode: 11241

contact info
Titolo: Prof.
Nome: Daniela
Cognome: Gradinaru
Email: send email
Telefono: -748697359
Fax: -2231461

RO (BUCHAREST) participant 0.00
6    ASTON UNIVERSITY

 Organization address address: ASTON TRIANGLE
city: BIRMINGHAM
postcode: B4 7ET

contact info
Titolo: Mr.
Nome: Gareth
Cognome: Evans
Email: send email
Telefono: +44 121 204 4798
Fax: +44 121 359 4796

UK (BIRMINGHAM) participant 0.00
7    BIOTESYS GMBH

 Organization address address: SCHELZTORSTRASSE 54-56
city: ESSLINGEN
postcode: 73728

contact info
Titolo: Ms.
Nome: Christiane
Cognome: Schoen
Email: send email
Telefono: -31057807
Fax: -31057813

DE (ESSLINGEN) participant 0.00
8    CRANFIELD UNIVERSITY

 Organization address address: College Road
city: CRANFIELD - BEDFORDSHIRE
postcode: MK43 0AL

contact info
Titolo: Ms.
Nome: Rose
Cognome: Suzanne
Email: send email
Telefono: +44 1234 758352
Fax: +44 1234758380

UK (CRANFIELD - BEDFORDSHIRE) participant 0.00
9    DNAGE BV

 Organization address address: Darwinweg 24
city: LEIDEN
postcode: 2333CR

contact info
Titolo: Dr.
Nome: Ingrid
Cognome: Van Der Pluijm
Email: send email
Telefono: -7038173
Fax: -7044722

NL (LEIDEN) participant 0.00
10    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Ms.
Nome: M.A.J.
Cognome: Van Zeijl
Email: send email
Telefono: +31 107043199
Fax: +31 107044743

NL (ROTTERDAM) participant 0.00
11    ETHNIKO IDRYMA EREVNON

 Organization address address: Vassileos Constantinou Avenue 48
city: ATHENS
postcode: 11635

contact info
Titolo: Dr.
Nome: Efstathios S.
Cognome: Gonos
Email: send email
Telefono: +30 210 7273756
Fax: +30 210 7273677

EL (ATHENS) participant 0.00
12    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

 Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029

contact info
Titolo: Mr.
Nome: Jose Louis
Cognome: Narro
Email: send email
Telefono: -2247002
Fax: -2247037

ES (MADRID) participant 0.00
13    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Mr.
Nome: Michael
Cognome: Robinson
Email: send email
Telefono: +44 20 7594 3866
Fax: +44 20 7594 3868

UK (LONDON) participant 0.00
14    INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK

 Organization address address: UL. LUDWIKA PASTEURA 3
city: WARSZAWA
postcode: 02 093

contact info
Titolo: Ms.
Nome: Marta
Cognome: Rucinska
Email: send email
Telefono: +48 22 589 23 30
Fax: +48 22 822 53 42

PL (WARSZAWA) participant 0.00
15    ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA

 Organization address address: Via Santa Margherita 5
city: ANCONA
postcode: 60124

contact info
Titolo: Dr.
Nome: Fiorella
Cognome: Marcellini
Email: send email
Telefono: +39 071 8004788
Fax: +39 071 35941

IT (ANCONA) participant 0.00
16    MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

 Organization address address: UNIVERSITAETSPLATZ 10
city: HALLE (Saale)
postcode: 6099

contact info
Titolo: Dr.
Nome: Manfred
Cognome: Jank
Email: send email
Telefono: +49 345 5521383
Fax: +49 345 5527687

DE (HALLE (Saale)) participant 0.00
17    NESTEC S.A

 Organization address address: Avenue Nestle 55
city: VEVEY
postcode: 1800

contact info
Titolo: Dr.
Nome: Sebastiano
Cognome: Collino
Email: send email
Telefono: +41 21 785 9336
Fax: +41 21 785 9486

CH (VEVEY) participant 0.00
18    OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN

 Organization address address: DR. IGNAZ SEIPEL-PLATZ 2
city: WIEN
postcode: 1010

contact info
Titolo: Prof.
Nome: Beatrix
Cognome: Grubeck-Loebenstein
Email: send email
Telefono: +43 512 5839190
Fax: +43 512 5839198

AT (WIEN) participant 0.00
19    RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN

 Organization address address: Antonie Van Leeuwenhoeklaan 9
city: BILTHOVEN
postcode: 3721 MA

contact info
Titolo: Mr.
Nome: Peter
Cognome: Van Altena
Email: send email
Telefono: -2742601
Fax: -2744473

NL (BILTHOVEN) participant 0.00
20    STRATICELL SCREENING TECHNOLOGIES

 Organization address address: RUE JEAN SONET 10 PARC SCIENTIFIQUE CREALYS CRI ANDROMEDE
city: GEMBLOUX LES ISNES
postcode: 5032

contact info
Titolo: Dr.
Nome: Michel
Cognome: Salmon
Email: send email
Telefono: +32 81 728580
Fax: +32 81 728589

BE (GEMBLOUX LES ISNES) participant 0.00
21    TAMPEREEN YLIOPISTO

 Organization address address: Kalevantie 4
city: TAMPERE
postcode: 33014

contact info
Titolo: Ms.
Nome: Hannele
Cognome: Auffermann
Email: send email
Telefono: +358 3 3556015
Fax: +358 3 35518970

FI (TAMPERE) participant 0.00
22    UNILEVER U.K. CENTRAL RESOURCES LIMITED

 Organization address address: "UNILEVER HOUSE, VICTORIA EMBANKMENT 100"
city: LONDON
postcode: EC4Y 0DY

contact info
Titolo: Dr.
Nome: Jonathan Richard
Cognome: Powell
Email: send email
Telefono: +44-1234 222418
Fax: -1234222117

UK (LONDON) participant 0.00
23    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

 Organization address address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
Titolo: Prof.
Nome: Maurizio
Cognome: Palucci
Email: send email
Telefono: +39 06 44291249
Fax: +39 06 44252865

IT (ROMA) participant 0.00
24    UNIVERSITAET HOHENHEIM

 Organization address address: Schloss Hohenheim 1
city: STUTTGART
postcode: 70599

contact info
Titolo: Prof.
Nome: Hans-Peter
Cognome: Liebig
Email: send email
Telefono: +49 711 45922000
Fax: +49 711 45924050

DE (STUTTGART) participant 0.00
25    UNIVERSITAET INNSBRUCK

 Organization address address: INNRAIN 52
city: INNSBRUCK
postcode: 6020

contact info
Titolo: Prof.
Nome: Beatrix
Cognome: Grubeck-Loebenstein
Email: send email
Telefono: +43 512 507 50855
Fax: +43 512 507 50899

AT (INNSBRUCK) participant 0.00
26    UNIVERSITE DE NAMUR ASBL

 Organization address address: Rue de Bruxelles 61
city: NAMUR
postcode: 5000

contact info
Titolo: Dr.
Nome: Michele
Cognome: Fontaine
Email: send email
Telefono: +32 81 725702
Fax: +32 81 725701

BE (NAMUR) participant 0.00
27    UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

 Organization address address: Place Jussieu 4
city: PARIS
postcode: 75252

contact info
Titolo: Prof.
Nome: Bertrand
Cognome: Friguet
Email: send email
Telefono: +33 1 44 27 8234
Fax: +33 1 44 278234

FR (PARIS) participant 0.00
28    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Dr.
Nome: Rik
Cognome: Audenaert
Email: send email
Telefono: +32 9 2446611
Fax: +32 9 2446610

BE (ZWIJNAARDE - GENT) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

blood    predict    physical    diseases    markers    heterogeneity    data    recruited    parent    serve    family    mathematical    onset    recent    influence    single    ones    candidate    subjects    proven    population    human    nature    biomarkers    individuals    belonging    biological    calculate    ageing    environmental    model    body    rate    geha    genetic    mark    related    living    individual    born    protein    dna    age   

 Obiettivo del progetto (Objective)

'The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.'

Introduzione (Teaser)

Ageing is an unavoidable process which brings along physical deterioration as well as age-related diseases. European researchers aimed to develop a mathematical model that could compute one's biological age based on a set of biomarkers.

Descrizione progetto (Article)

Genetic heterogeneity as well as environmental factors influence the rate of human ageing. To measure the true biological age of an individual and predict the onset of diseases, identifying age-related changes that serve as biomarkers is necessary.

Although many candidate biomarkers have been proposed, no single measurement has proven useful. This could be due to the multi-system nature of ageing which requires multiple parameters to be analysed at once. In this context, the EU-funded 'European study to establish biomarkers of human ageing' (http://www.mark-age.eu (MARK-AGE)) study proposed to identify a set of biomarkers of ageing to measure biological age accurately.

To achieve this, MARK-AGE partners performed a large study of over 2 300 individuals of different ages from seven locations across Europe. Another study group contained subjects born from a long-living parent belonging to a family with long-living siblings.

All enrolled subjects provided anthropometric, clinical and social information. Physical examination included measurements such as body mass index, waist and hip circumference as well as blood pressure and heart rate. In addition, subjects donated peripheral blood for further genetic and immunophenytoping analysis.

A series of putative DNA-based markers were examined such as DNA methylation, DNA repair and chromosome length. At the protein level, researchers looked at certain protein modifications and signs of protein damage. Since immune responses diminish with ageing, a number of immunological parameters were also evaluated such as antibody and cytokine levels. The study additionally included assays for measuring markers of metabolism and oxidative stress.

Out of these biomarkers, ten were selected based on their ability to better correlate the biological with the chronological age in the population. The results of assaying for these biomarkers were subsequently used to calculate a score that served as a prediction of an individual's biological age.

The long-term goal of the MARK-AGE study was to develop a mathematical model that could calculate one's biological age utilising these 10 biomarkers. This could help develop novel strategies for preventing accelerated ageing for a healthier lifestyle.

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TARKINAID (2012)

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