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STRomA SIGNED

Novel Matrix Stiffness-regulated Genes in Lymphangiogenesis and Angiogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 STRomA project word cloud

Explore the words cloud of the STRomA project. It provides you a very rough idea of what is the project "STRomA" about.

predominantly    mechanotransduction    mechanism    cells    disease    modulate    microscope    suggesting    vessel    hypothesize    protein    biological    vascular    differently    time    tissues    mechanical    fluorescent    implications    angiogenic    molecule    sequencing    family    forces    analyze    mouse    pivotal    cell    fundamentally    extracellular    composition    ecm    stiffness    matrices    recognize    performed    intracellular    blood    stiff    inside    ec    group    cultured    becs    soft    first    regulated    endothelial    translate    treatment    regulating    live    imaging    preliminary    models    shown    ultimately    signaling    matrix    techniques    cytoskeletal    surrounding    diseases    edema    bec    controls    physical    transgenic    3200    lecs    tree    visualize    regulatory    independent    action    me    generate    differential    lymphangiogenesis    lymphatic    lymph    angiogenesis    genes    rna    cgmp    leader    stimuli    interestingly    adhesions    integrally    significantly    ecs    sensor    differ    last    understand    vitro    actin    similarly    dynamics   

Project "STRomA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 162˙806.00

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 Project objective

Endothelial cells (ECs) recognize and respond to mechanical forces through their cell-cell and cell-matrix adhesions and translate physical stimuli into biological responses in a process called mechanotransduction. The composition and mechanical properties of the extracellular matrix (ECM) differ across the vascular tree, in its surrounding tissues and in development and diseases, such as edema formation. I have recently shown for the first time that ECM stiffness fundamentally controls lymphangiogenesis. I hypothesize that changes in ECM stiffness are a key regulatory mechanism of angiogenic processes in development and disease. A comprehensive analysis of novel ECM stiffness-regulated genes is pivotal to understand these processes integrally. In a preliminary study, I have performed differential RNA sequencing of blood (B) and lymphatic (L) ECs cultured on soft and stiff matrices. 3200 genes were regulated similarly in BECs and LECs in response to changes in matrix stiffness. Interestingly, the same number of genes was differently regulated. In the next two years, I will study the role of selected genes in lymphangiogenesis and angiogenesis in vitro and in transgenic mouse models with state-of-the-art microscope and live imaging techniques. First, I will analyze an actin-regulating protein family that is significantly regulated by matrix stiffness in both, BEC and LECs, suggesting a more general role in lymphangiogenesis and angiogenesis by regulating cytoskeletal dynamics. Second, I will study a molecule, which is involved in intracellular cGMP signaling and is predominantly regulated in LECs, suggesting a more specific role in lymphangiogenesis. Last, I will generate an in vitro fluorescent stiffness sensor to live-visualize changes in stiffness inside the EC. Ultimately, the proposed action can provide novel targets to modulate lymph and blood vessel formation with implications for edema treatment and will support me to become an independent group leader.

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The information about "STROMA" are provided by the European Opendata Portal: CORDIS opendata.

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