Opendata, web and dolomites

STRomA SIGNED

Novel Matrix Stiffness-regulated Genes in Lymphangiogenesis and Angiogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 STRomA project word cloud

Explore the words cloud of the STRomA project. It provides you a very rough idea of what is the project "STRomA" about.

analyze    imaging    lymphatic    ultimately    cultured    composition    transgenic    independent    disease    integrally    models    surrounding    edema    techniques    family    suggesting    cytoskeletal    ecm    translate    action    endothelial    bec    live    stiffness    cells    physical    ecs    angiogenic    extracellular    biological    becs    cell    rna    ec    blood    inside    lymphangiogenesis    me    implications    vascular    mechanotransduction    mechanism    tree    regulatory    matrices    sensor    3200    last    time    modulate    treatment    predominantly    performed    tissues    group    hypothesize    fluorescent    vessel    dynamics    genes    matrix    signaling    stimuli    soft    interestingly    visualize    vitro    intracellular    controls    protein    pivotal    regulating    mouse    significantly    adhesions    differ    generate    differently    cgmp    similarly    differential    angiogenesis    leader    stiff    actin    preliminary    regulated    fundamentally    sequencing    microscope    lymph    diseases    first    forces    shown    lecs    mechanical    understand    recognize    molecule   

Project "STRomA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 162˙806.00

Map

 Project objective

Endothelial cells (ECs) recognize and respond to mechanical forces through their cell-cell and cell-matrix adhesions and translate physical stimuli into biological responses in a process called mechanotransduction. The composition and mechanical properties of the extracellular matrix (ECM) differ across the vascular tree, in its surrounding tissues and in development and diseases, such as edema formation. I have recently shown for the first time that ECM stiffness fundamentally controls lymphangiogenesis. I hypothesize that changes in ECM stiffness are a key regulatory mechanism of angiogenic processes in development and disease. A comprehensive analysis of novel ECM stiffness-regulated genes is pivotal to understand these processes integrally. In a preliminary study, I have performed differential RNA sequencing of blood (B) and lymphatic (L) ECs cultured on soft and stiff matrices. 3200 genes were regulated similarly in BECs and LECs in response to changes in matrix stiffness. Interestingly, the same number of genes was differently regulated. In the next two years, I will study the role of selected genes in lymphangiogenesis and angiogenesis in vitro and in transgenic mouse models with state-of-the-art microscope and live imaging techniques. First, I will analyze an actin-regulating protein family that is significantly regulated by matrix stiffness in both, BEC and LECs, suggesting a more general role in lymphangiogenesis and angiogenesis by regulating cytoskeletal dynamics. Second, I will study a molecule, which is involved in intracellular cGMP signaling and is predominantly regulated in LECs, suggesting a more specific role in lymphangiogenesis. Last, I will generate an in vitro fluorescent stiffness sensor to live-visualize changes in stiffness inside the EC. Ultimately, the proposed action can provide novel targets to modulate lymph and blood vessel formation with implications for edema treatment and will support me to become an independent group leader.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STROMA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STROMA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More