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CancerADAPT SIGNED

Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CancerADAPT project word cloud

Explore the words cloud of the CancerADAPT project. It provides you a very rough idea of what is the project "CancerADAPT" about.

multiregional    cancer    course    therapeutic    cell    variations    rely    pca    molecular    canceradapt    complement    screening    progression    emanating    cancers    diversity    primary    govern    spatial    converging    establishment    exploited    therapy    omics    cues    central    metabolic    turn    alterations    transcriptomics    hamper    adapt    sustain    predicted    throughput    phenotype    pressure    vary    principles    postulate    molecule    predict    experimental    functionally    single    strategies    tumour    characterise    cells    vitro    rnaseq    mechanisms    implications    underlying    treatments    fundamental    microenvironments    efficacy    prostate    evolutionary    postulated    aberrations    phenotypic    computational    composition    poorly    vivo    generate    classify    mechanistically    microenvironment    men    disease    genomic    environment    metastasis    organism    silico    adaptability    diagnosed    deaths    phenotypes    imposed    source    small    intrinsic    adaptive    transcriptional    contributed    tumours    succeed    deconstructed   

Project "CancerADAPT" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS 

Organization address
address: PARQUE TECNOLOGICO EDIFICIO 801 A
city: DERIO VIZCAYA
postcode: 48160
website: www.cicbiogune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙999˙882 €
 EC max contribution 1˙999˙882 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) coordinator 1˙999˙882.00

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 Project objective

The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are intrinsic to primary tumours or metastasis. In CancerADAPT I postulate that cancer cells rely on adaptive transcriptional & metabolic mechanisms [converging on a Metabolic Phenotype] in order to rapidly succeed in their establishment in new microenvironments along disease progression. I aim to predict the molecular cues that govern the adaptive properties in prostate cancer (PCa), one of the most commonly diagnosed cancers in men and an important source of cancer-related deaths. I will exploit single cell RNASeq, spatial transcriptomics and multiregional OMICs in order to identify the transcriptional and metabolic diversity within tumours and along disease progression. I will complement experimental strategies with computational analyses that identify and classify the predicted adaptation strategies of PCa cells in response to variations in the tumour microenvironment. Metabolic phenotypes postulated to sustain PCa adaptability will be functionally and mechanistically deconstructed. We will identify therapeutic strategies emanating from these results through in silico methodologies and small molecule high-throughput screening, and evaluate their potential to hamper the adaptability of tumour cells in vitro and in vivo, in two specific aspects: metastasis and therapy response. CancerADAPT will generate fundamental understanding on how cancer cells adapt in our organism, in turn leading to therapeutic strategies that increase the efficacy of current treatments.

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The information about "CANCERADAPT" are provided by the European Opendata Portal: CORDIS opendata.

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