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CancerADAPT SIGNED

Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits

Total Cost €

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EC-Contrib. €

0

Partnership

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 CancerADAPT project word cloud

Explore the words cloud of the CancerADAPT project. It provides you a very rough idea of what is the project "CancerADAPT" about.

cell    metabolic    mechanistically    spatial    phenotype    therapeutic    men    silico    underlying    metastasis    succeed    tumours    implications    cancer    source    deconstructed    vitro    therapy    molecule    establishment    genomic    fundamental    adaptability    principles    mechanisms    canceradapt    evolutionary    treatments    transcriptional    exploited    aberrations    omics    single    pressure    classify    imposed    phenotypes    multiregional    deaths    sustain    complement    govern    rnaseq    tumour    composition    variations    molecular    throughput    generate    disease    intrinsic    primary    vary    hamper    computational    rely    characterise    phenotypic    strategies    pca    poorly    predicted    postulate    emanating    contributed    course    vivo    microenvironments    cues    organism    small    environment    diversity    progression    diagnosed    transcriptomics    efficacy    prostate    converging    cells    functionally    postulated    microenvironment    central    adapt    alterations    turn    cancers    adaptive    predict    screening    experimental   

Project "CancerADAPT" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS 

Organization address
address: PARQUE TECNOLOGICO EDIFICIO 801 A
city: DERIO VIZCAYA
postcode: 48160
website: www.cicbiogune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙999˙882 €
 EC max contribution 1˙999˙882 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) coordinator 1˙999˙882.00

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 Project objective

The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are intrinsic to primary tumours or metastasis. In CancerADAPT I postulate that cancer cells rely on adaptive transcriptional & metabolic mechanisms [converging on a Metabolic Phenotype] in order to rapidly succeed in their establishment in new microenvironments along disease progression. I aim to predict the molecular cues that govern the adaptive properties in prostate cancer (PCa), one of the most commonly diagnosed cancers in men and an important source of cancer-related deaths. I will exploit single cell RNASeq, spatial transcriptomics and multiregional OMICs in order to identify the transcriptional and metabolic diversity within tumours and along disease progression. I will complement experimental strategies with computational analyses that identify and classify the predicted adaptation strategies of PCa cells in response to variations in the tumour microenvironment. Metabolic phenotypes postulated to sustain PCa adaptability will be functionally and mechanistically deconstructed. We will identify therapeutic strategies emanating from these results through in silico methodologies and small molecule high-throughput screening, and evaluate their potential to hamper the adaptability of tumour cells in vitro and in vivo, in two specific aspects: metastasis and therapy response. CancerADAPT will generate fundamental understanding on how cancer cells adapt in our organism, in turn leading to therapeutic strategies that increase the efficacy of current treatments.

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The information about "CANCERADAPT" are provided by the European Opendata Portal: CORDIS opendata.

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