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Biochip-images SIGNED

A Breast Cancer Biomarker Point of CarePOCDiagnostic Platform Integrating Dual-Functionalized Nanoparticle for Magnetic Gradient Ranking and Electrochemical Sensing

Total Cost €

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EC-Contrib. €

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Partnership

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 Biochip-images project word cloud

Explore the words cloud of the Biochip-images project. It provides you a very rough idea of what is the project "Biochip-images" about.

mps    concerned    incidence    magnetophoresis    markers    quantification    lt    free    microfluidic    device    women    functionalized    micro    mins    redox    nanotechnology    15    integration    hosted    probes    point    females    candidate       worldwide    care    reported    immunological    chip    limit    me    electrode    convenient    dual    recruiting    combination    electroanalysis    additionally    poc    small    improvement    microelectrode    ca15    14    biomarkers    hsp90a    recognition    amplified    mag    separating    combining    ranking    mbs    pai    mortality    nanoparticles    samples    biomarker    cancers    proof    engineering    context    magnetic    detection    microchannels    electrochemically    assay    sensing    prior    intervention    marker    blood    patient    serum    diagnosis    25    primary    herein    nps    tumor    labeling    amplification    electrochemical    selectively    underpin    ml       arrays    platform    cancer    fabrication    gradient    breast    antibodies    positioned    20    neoplasm    quantities    zone    exerted    ng   

Project "Biochip-images" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

Breast cancer is the most common neoplasm in women and the second leading cause of cancer-related mortality in females worldwide, with 25.1% of incidence and 14.7% of mortality across all cancers. A convenient blood-based tumor marker test has the potential to underpin a significant improvement in early intervention. In this context, this proposal is concerned with development of a new point of care (POC) device for biomarker detection by exploiting a combination of state of the art magnetophoresis, electroanalysis, nanotechnology, and microfluidic integration. In the POC device, dual-functionalized magnetic nanoparticles (dual-NPs) with antibodies and redox probes will be capable of selectively recruiting specific markers from real patient samples and will additionally underpin amplified redox probes for detection. Second, using a magnetic gradient chip, composed of both magnetic gradient (Mag) and microelectrode (Me) arrays, the exerted magnetic gradient field will be capable of separating dual-NPs labeling biomarkers (MBs) from free dual-NPs (MPs) to be positioned at distinct sensing zone of micro-electrode, prior to assay. Herein, only those biomarkers hosted by dual-NPs, will be reported electrochemically for quantification. Three primary objectives are proposed by the candidate: i) development of dual-NPs combining immunological recognition and electrochemical amplification properties, ii) fabrication of Mag chip engineering Mag and Me arrays for magnetic gradient ranking and electrochemical sensing, iii) integration of POC platform with Mag and Me arrays, dual-NPs and microchannels, for cancer biomarker diagnosis. As a proof-of-concept, the developed POC device will be applied to the detection and quantification of breast cancer markers (CA15-3, PAI-1 and HSP90A) in a small (<20µL) blood serum. The detection limit of this device is expected to be ng/ml quantities and duration is estimated to 15 mins for each test with blood serum.

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The information about "BIOCHIP-IMAGES" are provided by the European Opendata Portal: CORDIS opendata.

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