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Biochip-images SIGNED

A Breast Cancer Biomarker Point of CarePOCDiagnostic Platform Integrating Dual-Functionalized Nanoparticle for Magnetic Gradient Ranking and Electrochemical Sensing

Total Cost €

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EC-Contrib. €

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Partnership

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 Biochip-images project word cloud

Explore the words cloud of the Biochip-images project. It provides you a very rough idea of what is the project "Biochip-images" about.

redox    candidate    ng    mag    electrode    mins    poc    exerted    platform    sensing    intervention    separating    14    small    immunological    context    cancer    pai    improvement    reported    mbs    zone    20    mps    free    breast       labeling    micro    blood    proof    fabrication    functionalized    chip    quantification    cancers    limit    incidence    engineering    microelectrode    integration    serum    recruiting    amplification    25    lt    hosted    electrochemical    tumor    nanoparticles    electroanalysis    15    neoplasm    ml    combination    nps    marker    care    hsp90a    assay    additionally    magnetic    herein    nanotechnology    biomarker    diagnosis    samples    electrochemically    detection    primary    concerned    females    point    markers    selectively    microfluidic    amplified    me    mortality    underpin    positioned    probes    women    patient    combining    convenient    prior    worldwide       microchannels    gradient    magnetophoresis    quantities    device    dual    arrays    recognition    ranking    antibodies    ca15    biomarkers   

Project "Biochip-images" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 184˙590.00

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 Project objective

Breast cancer is the most common neoplasm in women and the second leading cause of cancer-related mortality in females worldwide, with 25.1% of incidence and 14.7% of mortality across all cancers. A convenient blood-based tumor marker test has the potential to underpin a significant improvement in early intervention. In this context, this proposal is concerned with development of a new point of care (POC) device for biomarker detection by exploiting a combination of state of the art magnetophoresis, electroanalysis, nanotechnology, and microfluidic integration. In the POC device, dual-functionalized magnetic nanoparticles (dual-NPs) with antibodies and redox probes will be capable of selectively recruiting specific markers from real patient samples and will additionally underpin amplified redox probes for detection. Second, using a magnetic gradient chip, composed of both magnetic gradient (Mag) and microelectrode (Me) arrays, the exerted magnetic gradient field will be capable of separating dual-NPs labeling biomarkers (MBs) from free dual-NPs (MPs) to be positioned at distinct sensing zone of micro-electrode, prior to assay. Herein, only those biomarkers hosted by dual-NPs, will be reported electrochemically for quantification. Three primary objectives are proposed by the candidate: i) development of dual-NPs combining immunological recognition and electrochemical amplification properties, ii) fabrication of Mag chip engineering Mag and Me arrays for magnetic gradient ranking and electrochemical sensing, iii) integration of POC platform with Mag and Me arrays, dual-NPs and microchannels, for cancer biomarker diagnosis. As a proof-of-concept, the developed POC device will be applied to the detection and quantification of breast cancer markers (CA15-3, PAI-1 and HSP90A) in a small (<20µL) blood serum. The detection limit of this device is expected to be ng/ml quantities and duration is estimated to 15 mins for each test with blood serum.

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The information about "BIOCHIP-IMAGES" are provided by the European Opendata Portal: CORDIS opendata.

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