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Biochip-images SIGNED

A Breast Cancer Biomarker Point of CarePOCDiagnostic Platform Integrating Dual-Functionalized Nanoparticle for Magnetic Gradient Ranking and Electrochemical Sensing

Total Cost €

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EC-Contrib. €

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Partnership

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 Biochip-images project word cloud

Explore the words cloud of the Biochip-images project. It provides you a very rough idea of what is the project "Biochip-images" about.

marker    selectively    ca15    nanoparticles    nps    fabrication    arrays    probes    mortality    microchannels    antibodies    additionally    hsp90a    markers    context    gradient    device    pai    concerned    tumor    ranking    sensing    free    lt    mps    14    chip    ml    worldwide    reported    immunological    proof    mbs    electrochemically    underpin    primary    point    separating    ng    me    neoplasm    diagnosis    microelectrode    mins    limit    labeling    mag    zone    recruiting    hosted    prior    amplified    breast    cancers    small    improvement    amplification    detection    incidence    convenient    care    assay    exerted    20    samples    platform    microfluidic    25    magnetic    quantification    cancer    females    positioned    herein    electrochemical    integration    serum    biomarkers    electroanalysis    magnetophoresis    redox    candidate    micro    biomarker    poc    15    functionalized    recognition    intervention    women    electrode    blood    patient    quantities       combination    dual       combining    engineering    nanotechnology   

Project "Biochip-images" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 184˙590.00

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 Project objective

Breast cancer is the most common neoplasm in women and the second leading cause of cancer-related mortality in females worldwide, with 25.1% of incidence and 14.7% of mortality across all cancers. A convenient blood-based tumor marker test has the potential to underpin a significant improvement in early intervention. In this context, this proposal is concerned with development of a new point of care (POC) device for biomarker detection by exploiting a combination of state of the art magnetophoresis, electroanalysis, nanotechnology, and microfluidic integration. In the POC device, dual-functionalized magnetic nanoparticles (dual-NPs) with antibodies and redox probes will be capable of selectively recruiting specific markers from real patient samples and will additionally underpin amplified redox probes for detection. Second, using a magnetic gradient chip, composed of both magnetic gradient (Mag) and microelectrode (Me) arrays, the exerted magnetic gradient field will be capable of separating dual-NPs labeling biomarkers (MBs) from free dual-NPs (MPs) to be positioned at distinct sensing zone of micro-electrode, prior to assay. Herein, only those biomarkers hosted by dual-NPs, will be reported electrochemically for quantification. Three primary objectives are proposed by the candidate: i) development of dual-NPs combining immunological recognition and electrochemical amplification properties, ii) fabrication of Mag chip engineering Mag and Me arrays for magnetic gradient ranking and electrochemical sensing, iii) integration of POC platform with Mag and Me arrays, dual-NPs and microchannels, for cancer biomarker diagnosis. As a proof-of-concept, the developed POC device will be applied to the detection and quantification of breast cancer markers (CA15-3, PAI-1 and HSP90A) in a small (<20µL) blood serum. The detection limit of this device is expected to be ng/ml quantities and duration is estimated to 15 mins for each test with blood serum.

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The information about "BIOCHIP-IMAGES" are provided by the European Opendata Portal: CORDIS opendata.

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