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Biochip-images SIGNED

A Breast Cancer Biomarker Point of CarePOCDiagnostic Platform Integrating Dual-Functionalized Nanoparticle for Magnetic Gradient Ranking and Electrochemical Sensing

Total Cost €

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EC-Contrib. €

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Partnership

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 Biochip-images project word cloud

Explore the words cloud of the Biochip-images project. It provides you a very rough idea of what is the project "Biochip-images" about.

redox    neoplasm    20    combining    mortality    samples    amplified    exerted    zone    mps    recruiting    women    free    primary    hsp90a    chip    dual    tumor    proof    recognition    arrays    nps    electrode    markers    immunological    14    sensing    7    integration    combination    25    lt    electrochemically    additionally    point    microchannels    platform    context    probes    microfluidic    cancers    ng    15    me    electroanalysis    pai    microelectrode    small    intervention    herein    selectively    hosted    marker    worldwide    candidate    magnetophoresis    amplification    micro    limit    positioned    ml    improvement    engineering    ca15    females    prior    patient    concerned    device    serum    separating    mbs    assay    antibodies    functionalized    poc    nanoparticles    detection    diagnosis    convenient    gradient    breast    incidence    fabrication    blood    cancer    biomarker    care    1    quantities    labeling    biomarkers    mag    underpin    nanotechnology    mins    ranking    reported    electrochemical    quantification    magnetic   

Project "Biochip-images" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

Breast cancer is the most common neoplasm in women and the second leading cause of cancer-related mortality in females worldwide, with 25.1% of incidence and 14.7% of mortality across all cancers. A convenient blood-based tumor marker test has the potential to underpin a significant improvement in early intervention. In this context, this proposal is concerned with development of a new point of care (POC) device for biomarker detection by exploiting a combination of state of the art magnetophoresis, electroanalysis, nanotechnology, and microfluidic integration. In the POC device, dual-functionalized magnetic nanoparticles (dual-NPs) with antibodies and redox probes will be capable of selectively recruiting specific markers from real patient samples and will additionally underpin amplified redox probes for detection. Second, using a magnetic gradient chip, composed of both magnetic gradient (Mag) and microelectrode (Me) arrays, the exerted magnetic gradient field will be capable of separating dual-NPs labeling biomarkers (MBs) from free dual-NPs (MPs) to be positioned at distinct sensing zone of micro-electrode, prior to assay. Herein, only those biomarkers hosted by dual-NPs, will be reported electrochemically for quantification. Three primary objectives are proposed by the candidate: i) development of dual-NPs combining immunological recognition and electrochemical amplification properties, ii) fabrication of Mag chip engineering Mag and Me arrays for magnetic gradient ranking and electrochemical sensing, iii) integration of POC platform with Mag and Me arrays, dual-NPs and microchannels, for cancer biomarker diagnosis. As a proof-of-concept, the developed POC device will be applied to the detection and quantification of breast cancer markers (CA15-3, PAI-1 and HSP90A) in a small (<20µL) blood serum. The detection limit of this device is expected to be ng/ml quantities and duration is estimated to 15 mins for each test with blood serum.

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The information about "BIOCHIP-IMAGES" are provided by the European Opendata Portal: CORDIS opendata.

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