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DNA-DOCK SIGNED

Precision Docking of Very Large DNA Cargos in Mammalian Genomes

Total Cost €

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EC-Contrib. €

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Partnership

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 DNA-DOCK project word cloud

Explore the words cloud of the DNA-DOCK project. It provides you a very rough idea of what is the project "DNA-DOCK" about.

cargos    affordable    sophisticated    circuitry    representing    multifunctional    array    pairs    integration    accelerate    assembly    rewarding    cell    catalysing    unlock    genomes    docking    scientific    technologies    biomedical    unparalleled    engineering    dna    once    breaking    generate    full    interface    thousands    rational    resolve    unaddressed    evolution    designer    rewrite    resolving    fine    generally    vital    largely    precision    tools    capacities    unprecedented    provides    human    base    bottleneck    capacity    sites    carry    disrupt    transduction    broad    code    tool    editing    nanodevices    functions    gene    revolution    unmet    pair    small    genomic    functionalities    capability    genome    speed    worldwide    mammalian    parallelized    synthesis    techniques    exceptionally    safe    equal    insert    genes    communities    local    efficiency    synthetic    ease    applicable    insertions    vitro    edits    industrial    darwinian    tuneable    crispr    medical    remained    producing    utilize    date    circuits    complemented    multicomponent    breath    programmable    unmatched    cas9    goals    flexible    ground    edit    virus    aspire   

Project "DNA-DOCK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙498˙578 €
 EC max contribution 2˙498˙578 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 2˙498˙578.00

Map

 Project objective

Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.

We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.

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The information about "DNA-DOCK" are provided by the European Opendata Portal: CORDIS opendata.

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