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DNA-DOCK SIGNED

Precision Docking of Very Large DNA Cargos in Mammalian Genomes

Total Cost €

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EC-Contrib. €

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Partnership

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 DNA-DOCK project word cloud

Explore the words cloud of the DNA-DOCK project. It provides you a very rough idea of what is the project "DNA-DOCK" about.

biomedical    genes    representing    genome    programmable    carry    editing    communities    docking    transduction    human    techniques    rewarding    edits    cas9    capacity    precision    sites    producing    multifunctional    insertions    crispr    aspire    efficiency    tuneable    engineering    unaddressed    full    insert    evolution    generally    tool    speed    goals    safe    synthetic    remained    date    once    unmatched    rewrite    disrupt    cell    genomic    capability    breaking    unmet    genomes    fine    functions    darwinian    circuitry    cargos    array    interface    local    ease    utilize    flexible    provides    pairs    complemented    affordable    vitro    multicomponent    technologies    virus    integration    worldwide    vital    generate    tools    revolution    synthesis    bottleneck    resolving    medical    base    sophisticated    edit    pair    dna    scientific    functionalities    broad    accelerate    thousands    unprecedented    nanodevices    mammalian    parallelized    exceptionally    ground    rational    applicable    equal    resolve    small    capacities    unparalleled    assembly    breath    designer    circuits    code    catalysing    gene    largely    industrial    unlock   

Project "DNA-DOCK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙498˙578 €
 EC max contribution 2˙498˙578 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 2˙498˙578.00

Map

 Project objective

Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.

We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.

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The information about "DNA-DOCK" are provided by the European Opendata Portal: CORDIS opendata.

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