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DNA-DOCK SIGNED

Precision Docking of Very Large DNA Cargos in Mammalian Genomes

Total Cost €

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EC-Contrib. €

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Partnership

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 DNA-DOCK project word cloud

Explore the words cloud of the DNA-DOCK project. It provides you a very rough idea of what is the project "DNA-DOCK" about.

bottleneck    utilize    interface    unprecedented    resolve    date    scientific    designer    array    insert    thousands    tool    ground    parallelized    resolving    base    genomic    equal    genome    circuits    technologies    generate    unaddressed    fine    unlock    pairs    gene    biomedical    programmable    capability    catalysing    tuneable    speed    once    aspire    capacities    code    largely    editing    breaking    docking    medical    small    darwinian    affordable    vital    representing    industrial    flexible    pair    cell    edit    producing    functions    unparalleled    revolution    disrupt    provides    synthesis    rewarding    capacity    integration    vitro    cas9    unmatched    techniques    tools    engineering    synthetic    insertions    genomes    multicomponent    precision    ease    sites    unmet    generally    complemented    carry    genes    exceptionally    crispr    accelerate    circuitry    remained    communities    full    applicable    assembly    breath    multifunctional    evolution    mammalian    sophisticated    dna    rational    functionalities    virus    rewrite    local    broad    nanodevices    edits    goals    efficiency    safe    worldwide    transduction    cargos    human   

Project "DNA-DOCK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙498˙578 €
 EC max contribution 2˙498˙578 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 2˙498˙578.00

Map

 Project objective

Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.

We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.

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The information about "DNA-DOCK" are provided by the European Opendata Portal: CORDIS opendata.

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