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DNA-DOCK SIGNED

Precision Docking of Very Large DNA Cargos in Mammalian Genomes

Total Cost €

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EC-Contrib. €

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Partnership

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 DNA-DOCK project word cloud

Explore the words cloud of the DNA-DOCK project. It provides you a very rough idea of what is the project "DNA-DOCK" about.

applicable    speed    resolving    broad    unmatched    functions    utilize    evolution    rewarding    docking    circuits    carry    edit    parallelized    integration    designer    multifunctional    bottleneck    rational    industrial    date    synthetic    insert    remained    biomedical    pairs    local    aspire    breaking    accelerate    ground    cargos    insertions    scientific    engineering    worldwide    synthesis    flexible    vital    mammalian    cas9    nanodevices    programmable    catalysing    transduction    medical    interface    revolution    unlock    generally    resolve    assembly    vitro    safe    once    dna    tuneable    capacity    unaddressed    goals    multicomponent    pair    tool    ease    genomes    cell    representing    equal    circuitry    thousands    techniques    generate    genes    genomic    sophisticated    complemented    disrupt    crispr    human    code    unparalleled    producing    largely    darwinian    functionalities    sites    unprecedented    capacities    fine    unmet    capability    genome    virus    exceptionally    breath    array    efficiency    tools    communities    editing    gene    small    base    technologies    full    precision    rewrite    provides    affordable    edits   

Project "DNA-DOCK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙498˙578 €
 EC max contribution 2˙498˙578 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 2˙498˙578.00

Map

 Project objective

Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.

We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.

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The information about "DNA-DOCK" are provided by the European Opendata Portal: CORDIS opendata.

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