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'Filling the gaps' in the Schengen pathway for plant root Casparian strip integrity

Total Cost €


EC-Contrib. €






 SCHENGEN-ROOT project word cloud

Explore the words cloud of the SCHENGEN-ROOT project. It provides you a very rough idea of what is the project "SCHENGEN-ROOT" about.

linear    identification    casparian    nutrient    plants    details    localisation    strip    elusive    engineering    receptors    perceives    elucidating    fuse    domain    resolve    functions    diverse    barriers    missing    appears    understand    central    broad    tissues    water    insights    share    perfect    biological    specificity    initiated    organs    downstream    ensures    seal    unknown    mechanism    transducers    sgn    regulate    secondly    tissue    fusion    pollen    cifs    homeostasis    cascades    receptor    diffusion    sub    model    continuous    co    additional    embryonic    integrity    signalling    intend    function    cs    safeguard    branched    barrier    starts    regulated    uncover    microdomains    cuticle    potentially    clarify    aligned    sophisticated    mapks    forge    molecular    root    mechanistic    lignification    ligand    mapk    modules    characterise    membrane    govern    gaps    coat    activated    inducible    off    first    basis    establishes    thirdly    monitor    give    appear    sgn3   

Project "SCHENGEN-ROOT" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 203˙149.00


 Project objective

Plants have developed sophisticated barriers in various tissues and organs to safeguard integrity. To monitor barrier integrity, plants appear to have evolved similar systems that share signalling modules. The receptor/ligand signalling pathway initiated by SGN3/CIFs establishes the integrity of the Casparian strip (CS), a root diffusion barrier that is essential for controlling nutrient and water homeostasis. The CS starts off as aligned microdomains that eventually fuse to forge a continuous barrier. The SGN pathway is crucial to “find and seal gaps” between the microdomains. However, the mechanism that ensures perfect domain fusion is not well understood.

Here, I aim to uncover missing mechanistic details and characterise central unknown elements in a proposed, branched SGN pathway. I intend to identify potential SGN3 co-receptors and additional membrane transducers, and to investigate the elusive role of MAPKs during CS formation. The findings will be crucial to resolve pathway features that the current linear model cannot explain. First, identifying co-receptors is necessary to understand how SGN3 is activated. SGN3 also appears to be involved in embryonic cuticle and pollen coat formation. Therefore, co-receptor identification would clarify whether SGN3 perceives the same or different ligand to govern distinct barrier formation processes. Secondly, identifying additional transducers will provide a molecular basis for understanding two potentially distinct lignification processes regulated by SGN3. This will provide broad insights into how receptors regulate specific sub-functions. Thirdly, MAPK cascades are activated downstream of many receptor/ligand pathways. Elucidating their function in the SGN pathway will give insights into diverse biological processes. Overall, this project will provide a key model to study specificity and localisation of signalling modules, leading towards tissue-specific and inducible barrier engineering in plants.

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The information about "SCHENGEN-ROOT" are provided by the European Opendata Portal: CORDIS opendata.

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