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CLOCK SIGNED

Characterization of the circadian chromatin landscape using a novel CRISPR/Cas9-guided proximity-labelling technique

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CLOCK project word cloud

Explore the words cloud of the CLOCK project. It provides you a very rough idea of what is the project "CLOCK" about.

oscillators    jet    few    caused    endogenous    dysregulation    secondary    treatment    cardiovascular    left    rhythms    regulatory    humans    central    limitations    union    function    proteomics    boxes    mammalian    rre    metabolic    unbiased    binding    stay    shown    caspex    dynamics    circadian    labelling    regions    clock    strategies    pathologies    proteins    lag    proposes    possess    drive    sequences    landscape    generation    clocks    environmental    subsequent    regulators    crispr    living    diseases    synchrony    characterization    rhythm    chromatin    health    node    regulation    functions    24    diabetes    screen    quantitative    organisms    multiple    cycles    neurodegenerative    mechanism    cancer    cas9    shift    located    locus    rres    modifiers    rnai    oscillator    genomic    enhancer    promoter    box    behavioral    region    molecular    mainly    rhythmic    apex    tight    first    protein    transcription    cis    disorders    obesity    prevalent    physiological    cells    gaps    insights   

Project "CLOCK" data sheet

The following table provides information about the project.

Coordinator
CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 162˙806.00

Map

 Project objective

To stay in synchrony with environmental cycles, most living organisms possess endogenous clocks. Circadian clocks are molecular oscillators present in most mammalian cells that drive circadian (~24 h) rhythms of a wide range of molecular, physiological and behavioral functions. Circadian clocks are essential for health. In humans their dysregulation (e.g. caused by shift work, jet lag etc.) has been associated with the development of multiple pathologies (e.g. cancer, metabolic diseases like diabetes and obesity as well as cardiovascular and neurodegenerative diseases) prevalent in the European Union.

One central aspect of molecular oscillator function is the tight regulation of circadian transcription. Over the years, several proteins and cis-regulatory enhancer elements (i.e. specific sequences located around the promoter region, e.g. E-box, RRE, D-box) have been shown to be essential for circadian transcription. However, mainly because of technical limitations, those studies focused on few regulators and have left many gaps in the understanding of the dynamics of the circadian transcription. Therefore, this project proposes to use state-of-the-art quantitative genomic-locus proteomics to provide the first comprehensive and unbiased characterization of the rhythmic protein binding at key circadian regulatory regions – a key regulatory node of circadian clock function Using a CRISPR/Cas9-APEX labelling method (CASPEX), we will first characterize the circadian chromatin landscape of the three main circadian regulatory regions (i.e. E-boxes, RREs, D-boxes). We expect to find new clock modifiers, whose role for circadian rhythm generation will be investigated in a subsequent part of the project, using an RNAi-based secondary screen. Overall, this project will provide novel insights in the circadian oscillator mechanism in humans, which is essential for developing better treatment strategies for circadian clock-associated disorders.

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The information about "CLOCK" are provided by the European Opendata Portal: CORDIS opendata.

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