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MitoCRISTAE SIGNED

Mitochondrial Cristae Biogenesis

Total Cost €

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EC-Contrib. €

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Partnership

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 MitoCRISTAE project word cloud

Explore the words cloud of the MitoCRISTAE project. It provides you a very rough idea of what is the project "MitoCRISTAE" about.

morphologies    disturbed    powerhouses    mitochondria    striking    diseased    2d    cryo    proteins    inner    generation    minflux    enigma    few    imaging    super    function    pilot    cells    emerged    cell    human    synchronous    respiratory    cancer    primary    biochemistry    mitochondrial    gene    atp    single    edited    disorders    form    mutations    technologies    electron    first    invaginations    paradigm    ago    counting    cristae    deeply    structurally    combining    mass    treatment    strategies    diseases    label    microscopy    live    cardiomyopathies    healthy    thereby    initially    dynamic    relied    lines    time    spectrometry    quantitative    neurodegeneration    devastating    metabolic    spark    shift    experiments    theses    de    mutant    molecule    swath    eukaryotic    outcome    novo    defective    intertwined    last    insights    innovative    conserved    radically    1950s    mitopathies    altogether    successful    resolution    3d    primarily    series    induce    biogenesis    deep    maintained    membrane    ultrastructure    follow    irregular    free   

Project "MitoCRISTAE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS 

Organization address
address: Robert-Koch-Strasse 40
city: GOETTINGEN
postcode: 37075
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙286˙248 €
 EC max contribution 2˙286˙248 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS DE (GOETTINGEN) coordinator 1˙170˙655.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙115˙592.00

Map

 Project objective

Mitochondrial cristae biogenesis is an enigma ever since the first imaging of mitochondria, the ‘powerhouses’ of eukaryotic cells, by electron microscopy in the 1950s. The mitochondrial cristae, dynamic and structurally conserved invaginations of the mitochondrial inner membrane, are essential for respiratory ATP generation. Thereby, the form and function of the mitochondrial inner membrane are deeply intertwined. Indeed, irregular or disturbed cristae morphologies are believed to cause numerous human diseases, including neurodegeneration, cardiomyopathies, metabolic disorders and cancer. Previous approaches to study cristae biogenesis have relied primarily on the use of 2D electron microscopy and biochemistry to analyse mutant cells defective in cristae formation. Based on striking pilot experiments, we propose to study cristae biogenesis by a radically different approach. We will induce synchronous cristae development in gene-edited cell lines initially defective in cristae formation. We will then follow de novo cristae biogenesis over time by combining a series of enabling approaches, including live cell and MINFLUX super-resolution microscopy, 3D (cryo) electron microscopy, label-free (SWATH) mass spectrometry, and single molecule counting. These technologies have just emerged in the last few years, and thus this proposal would not have been possible a few years ago. The primary aim of this proposal is to establish a deep, comprehensive and quantitative understanding of cristae biogenesis in human cells. Using theses insights, we will also investigate the effects of mutations in mitochondrial proteins associated with human diseases on cristae biogenesis. Altogether, if successful, the outcome will represent a paradigm shift in our knowledge of how mitochondrial ultrastructure in healthy and diseased cells is generated and maintained. Our findings might spark innovative and novel strategies for the treatment of devastating human mitopathies.

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The information about "MITOCRISTAE" are provided by the European Opendata Portal: CORDIS opendata.

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