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NEUcrest SIGNED

Training European Experts in Multiscale Studies of Neural Crest Development and Disorders: from Patient to Model Systems and Back again.

Total Cost €

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EC-Contrib. €

0

Partnership

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 NEUcrest project word cloud

Explore the words cloud of the NEUcrest project. It provides you a very rough idea of what is the project "NEUcrest" about.

caused    broad    public    tissue    fundamentals    group    drug    difficult    heart    interdisciplinary    esrs    defects    takes    mutations    multidisciplinary    biological    neural    phenotyping    cleftvpalate    models    unified    improvements    phenotypes    create    melanoma    screening    causative    strategy    animal    of    derivatives    crest    understand    cellular    diseases    neuroblastoma    clinic    pharma    regulation    back    training    genes    framework    integrative    scientific    disease    discovery    reactivate    industry    translational    networking    adrenals    cancers    clinical    optimise    birth    genetic    events    academia    embryonic    neucrest    healthcare    interface    initiation    human    functional    synergistic    computational    scientists    neurocristopathy    health    molecular    lineage    nc    therapeutics    gut    syndromes    programs    creative    network    environmental    tumour    model    candidate    innovative    diverse    pleiotropic    clinicians    strategies    patients    gene    genetics    vivo    networks    neurocristopathies    provides   

Project "NEUcrest" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 4˙156˙404 €
 EC max contribution 4˙156˙404 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 549˙604.00
2    UNIVERSITY OF EAST ANGLIA UK (NORWICH) participant 606˙345.00
3    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) participant 549˙368.00
4    UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE ES (ELCHE) participant 501˙809.00
5    KING'S COLLEGE LONDON UK (LONDON) participant 303˙172.00
6    STEMCELL TECHNOLOGIES UK LTD UK (CAMBRIDGE) participant 303˙172.00
7    AZELEAD FR (MONTPELLIER) participant 274˙802.00
8    IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION FR (PARIS 15) participant 274˙802.00
9    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 265˙619.00
10    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 264˙207.00
11    TEL AVIV UNIVERSITY IL (TEL AVIV) participant 263˙500.00

Map

 Project objective

Neurocristopathies caused by defects in the neural crest (NC) encompass a broad group of diseases from birth defects (cleftvpalate) to complex syndromes affecting systems such as heart, gut and adrenals. Because NC derivatives are diverse, mutations affecting this lineage can lead to pleiotropic phenotypes making it difficult to understand the causative events. Furthermore, NC-derived cancers, (e.g. melanoma and neuroblastoma) reactivate embryonic programs during tumour initiation. Our aim is to create a unique interdisciplinary network of scientists and clinicians partners from academia, healthcare, industry and the public sector with experience in gene discovery, genetics, functional studies and in vivo phenotyping aimed at training creative and innovative ESRs to study the overall genetic, molecular and environmental regulation of NC tissue in human health. To study each of complex aspects of NC and tumour formation, NEUcrest provides a synergistic framework for comprehensive analysis of candidate genes and biological processes, from patients to model systems to pharma and back to the clinic. With the aim to develop a unified strategy to identify new genetic and environmental factors that contribute to disease and to develop new drug targets for therapeutics, ESRs will address following scientific challenges: undertake novel gene discovery approaches; establish cellular/animal models of disease; establish integrative strategies for understanding neurocristopathies; optimise computational modelling of NC gene networks; establish translational strategies for drug screening in NC-related diseases; improve clinical management strategies of NC-disease and interface with patients and the public. Our training program takes into account training through research as well as multidisciplinary partnerships and networking opportunities. All together, this will improve our understanding of the fundamentals of neurocristopathy and contribute to improvements in healthcare.

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The information about "NEUCREST" are provided by the European Opendata Portal: CORDIS opendata.

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