Opendata, web and dolomites


Novel vascular-like BBB-on-a-chip

Total Cost €


EC-Contrib. €






 NOVACHIP project word cloud

Explore the words cloud of the NOVACHIP project. It provides you a very rough idea of what is the project "NOVACHIP" about.

diseases    capillaries    assembly    microfluidic    biologically    disease    blood    shown    native    compare    toxicity    quantifying    exhibit    sizes    components    there    resonance    linked    poc    commercially    brain    matrix    kidney    combines    tissue    chip    acute    starting    ecm    therapies    designed    novachip    predict    model    reduce    generating    disorders    biological    human    vitro    break    resemble    properly    ineffective    overcome    screening    found    capacity    incorporate    3d    animal    safer    cells    geometries    bioprinting    alzheimer    companies    variety    models    plaques    treatments    imaging    preparation    self    20    stiffness    vessels    barrier    biomechanical    pharmaceutical    biomarkers    rat    extracellular    practical    neurological    made    grant    bbb    ad    permeability    industry    molecules    recreating    indicate    inability    endothelialized    vivo    scalable    fabrication    strofunscaff    erc    off    relevance    fluidic    pathophysiology    evident    thanks    magnetic    technique    complications    vessel    drug    patent    limited    obstacle    personalized    reports    constitutes    functional    drugs    structural    risk    patients    mri    grow    nephrotoxicity    proposes   

Project "NOVACHIP" data sheet

The following table provides information about the project.


Organization address
address: University Park
postcode: NG7 2RD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙951 €
 EC max contribution 149˙951 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2020
 Duration (year-month-day) from 2020-11-01   to  2022-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

There is great need to develop safer and more biologically relevant models for drug screening. Recent reports indicate that up to 20% of acute kidney complications can be linked to drug-induced nephrotoxicity and more than 40 molecules found to reduce Alzheimer’s Disease (AD)-related plaques in animal models were shown to be ineffective in AD patients. It is increasingly evident that both in vitro and in vivo models being used to develop drugs have a limited capacity to predict the pathophysiology of human disease, personalized response, and off-target drug toxicity. The inability to properly test drugs and treatments to diseases such as AD constitutes a risk for pharmaceutical companies and a major obstacle to overcome. This ERC PoC proposal aims to establish a practical microfluidic fabrication process capable of recreating structural and biomechanical features of native blood vessels. Specifically, we aim to develop a scalable 3D Blood-Brain-Barrier in vitro model (BBB-on-a-chip) able to provide a higher level of biological relevance than current in vitro models. The development of such a system would represent a major break-through for the pharmaceutical industry generating therapies for a variety of neurological disorders. Thanks to the ERC Starting Grant STROFUNSCAFF, we have developed a simple fabrication process that combines bioprinting and self-assembly to grow functional fluidic devices with endothelialized vessel-like capillaries (patent application in preparation). NOVACHIP proposes to a) build scalable microfluidic devices made from capillaries that incorporate relevant cells and extracellular matrix (ECM) components, exhibit tissue-like stiffness, and can be designed with specific sizes and geometries to better resemble the native BBB and b) compare it to a commercially available in vitro model as well as c) an established rat model by quantifying permeability of specific imaging biomarkers for Magnetic Resonance Imaging (MRI) technique.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NOVACHIP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NOVACHIP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

RTMFRM (2019)

Room Temperature Magnetic Resonance Force Microscopy

Read More  

NeuroMag (2019)

The Neurological Basis of the Magnetic Sense

Read More