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NOVACHIP SIGNED
Novel vascular-like BBB-on-a-chip
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0NOVACHIP project word cloud
Explore the words cloud of the NOVACHIP project. It provides you a very rough idea of what is the project "NOVACHIP" about.
neurological
diseases
magnetic
novachip
toxicity
grow
inability
kidney
cells
ecm
structural
geometries
capacity
extracellular
disease
strofunscaff
functional
therapies
safer
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native
assembly
vitro
sizes
poc
bioprinting
blood
rat
industry
linked
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reduce
indicate
resonance
model
plaques
reports
technique
pharmaceutical
preparation
ineffective
grant
exhibit
recreating
variety
treatments
barrier
components
imaging
bbb
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ad
human
break
designed
risk
brain
predict
models
drugs
there
biomechanical
biologically
drug
acute
stiffness
compare
evident
vivo
obstacle
practical
alzheimer
nephrotoxicity
limited
complications
patent
made
scalable
erc
chip
patients
vessels
incorporate
3d
20
pathophysiology
generating
mri
constitutes
resemble
combines
biomarkers
commercially
animal
found
matrix
endothelialized
microfluidic
disorders
companies
relevance
overcome
permeability
shown
thanks
screening
tissue
biological
starting
molecules
properly
self
proposes
quantifying
fluidic
fabrication
off
Project "NOVACHIP" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF NOTTINGHAM
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 149˙951 € |
| EC max contribution | 149˙951 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-11-01 to 2022-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF NOTTINGHAM | UK (NOTTINGHAM) | coordinator | 149˙951.00 |
Map
Project objective
There is great need to develop safer and more biologically relevant models for drug screening. Recent reports indicate that up to 20% of acute kidney complications can be linked to drug-induced nephrotoxicity and more than 40 molecules found to reduce Alzheimer’s Disease (AD)-related plaques in animal models were shown to be ineffective in AD patients. It is increasingly evident that both in vitro and in vivo models being used to develop drugs have a limited capacity to predict the pathophysiology of human disease, personalized response, and off-target drug toxicity. The inability to properly test drugs and treatments to diseases such as AD constitutes a risk for pharmaceutical companies and a major obstacle to overcome. This ERC PoC proposal aims to establish a practical microfluidic fabrication process capable of recreating structural and biomechanical features of native blood vessels. Specifically, we aim to develop a scalable 3D Blood-Brain-Barrier in vitro model (BBB-on-a-chip) able to provide a higher level of biological relevance than current in vitro models. The development of such a system would represent a major break-through for the pharmaceutical industry generating therapies for a variety of neurological disorders. Thanks to the ERC Starting Grant STROFUNSCAFF, we have developed a simple fabrication process that combines bioprinting and self-assembly to grow functional fluidic devices with endothelialized vessel-like capillaries (patent application in preparation). NOVACHIP proposes to a) build scalable microfluidic devices made from capillaries that incorporate relevant cells and extracellular matrix (ECM) components, exhibit tissue-like stiffness, and can be designed with specific sizes and geometries to better resemble the native BBB and b) compare it to a commercially available in vitro model as well as c) an established rat model by quantifying permeability of specific imaging biomarkers for Magnetic Resonance Imaging (MRI) technique.
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The information about "NOVACHIP" are provided by the European Opendata Portal: CORDIS opendata.
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