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DynaGrow SIGNED

Dynamic Growth and Replication in Coacervate Protocells

Total Cost €

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EC-Contrib. €

0

Partnership

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 DynaGrow project word cloud

Explore the words cloud of the DynaGrow project. It provides you a very rough idea of what is the project "DynaGrow" about.

living    inspired    longer    modern    disordered    division    holds    protocells    spontaneous    membrane    molecules    condensed    inside    act    predicted    undergo    template    surrounding    spontaneously    coacervates    shape    right    complementary    science    emergence    elongation    organelles    concentrates    free    droplets    chains    degree    proteins    reactions    sufficiently    either    molecular    chemical    rates    coacervate    blocks    intrinsically    building    extinct    oligopeptides    evolution    fuel    previously    replication    mysteries    directed    replicators    cells    life    rate    sequences    dilution    place    coacervation    complexity    patterns    liquid    ostwald    exactly    peptides    class    replicate    see    dual    instability    destined    templates    compartment    mark    reached    divides    biggest    found    appreciable    mixtures    ripening    active    modifications    peptide    fundamental    environment    functionalized    conjugation    fragments    never    divide    darwinian    lack    stable    sequence    minimal   

Project "DynaGrow" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 1˙500˙000.00

Map

 Project objective

Replication and division are two of the most fundamental properties of living systems. Without replication, Darwinian evolution would not be possible, and life could never have reached the degree of complexity we see today. However, exactly how mixtures of non-living molecules developed the ability to replicate and divide, remains one of the biggest mysteries in modern science. Various molecular replicators have been investigated previously, but they are all destined to become extinct by dilution, since they lack a surrounding compartment that divides spontaneously during replication.

In this proposal, we aim at developing a new class of coacervate-based protocells that are capable of active growth and template-directed replication. The coacervates we propose here are condensed liquid droplets with a unique dual role: they act as a compartment that holds together and concentrates the template molecules and the building blocks, and they provide the right chemical environment for the replication reactions to take place at an appreciable rate. The coacervate-based protocells are composed of oligopeptides with low complexity sequences, inspired by the intrinsically disordered proteins found in membrane-free organelles inside cells. Active growth is achieved through fuel-driven reactions, either by elongation of existing peptides or by specific chemical modifications at the peptide side chains that enhance their coacervation potential. Longer peptides can also act as templates for conjugation of end-functionalized peptide fragments with sequence patterns complementary to the template. Protocells with sufficiently high growth or replication rates are not only stable against Ostwald ripening, but are also predicted to undergo spontaneous division through a shape instability. This would mark a key step in the emergence of minimal cells and open the way for the evolution of more complex life-like systems.

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The information about "DYNAGROW" are provided by the European Opendata Portal: CORDIS opendata.

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