Opendata, web and dolomites


Dynamic Growth and Replication in Coacervate Protocells

Total Cost €


EC-Contrib. €






 DynaGrow project word cloud

Explore the words cloud of the DynaGrow project. It provides you a very rough idea of what is the project "DynaGrow" about.

predicted    life    never    reactions    chains    modern    patterns    replicators    sufficiently    coacervate    previously    right    lack    evolution    fragments    dilution    conjugation    complementary    exactly    mixtures    environment    building    templates    elongation    instability    template    complexity    minimal    darwinian    modifications    active    divide    place    rate    molecules    proteins    ripening    biggest    fuel    replicate    sequence    mysteries    intrinsically    membrane    longer    molecular    class    either    undergo    free    extinct    compartment    mark    destined    see    peptides    living    condensed    disordered    oligopeptides    divides    rates    directed    liquid    dual    organelles    degree    emergence    inspired    division    reached    replication    appreciable    fundamental    functionalized    act    spontaneous    coacervates    chemical    surrounding    sequences    found    blocks    concentrates    science    inside    droplets    stable    holds    ostwald    shape    cells    coacervation    spontaneously    peptide    protocells   

Project "DynaGrow" data sheet

The following table provides information about the project.


Organization address
postcode: 6525 EZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Replication and division are two of the most fundamental properties of living systems. Without replication, Darwinian evolution would not be possible, and life could never have reached the degree of complexity we see today. However, exactly how mixtures of non-living molecules developed the ability to replicate and divide, remains one of the biggest mysteries in modern science. Various molecular replicators have been investigated previously, but they are all destined to become extinct by dilution, since they lack a surrounding compartment that divides spontaneously during replication.

In this proposal, we aim at developing a new class of coacervate-based protocells that are capable of active growth and template-directed replication. The coacervates we propose here are condensed liquid droplets with a unique dual role: they act as a compartment that holds together and concentrates the template molecules and the building blocks, and they provide the right chemical environment for the replication reactions to take place at an appreciable rate. The coacervate-based protocells are composed of oligopeptides with low complexity sequences, inspired by the intrinsically disordered proteins found in membrane-free organelles inside cells. Active growth is achieved through fuel-driven reactions, either by elongation of existing peptides or by specific chemical modifications at the peptide side chains that enhance their coacervation potential. Longer peptides can also act as templates for conjugation of end-functionalized peptide fragments with sequence patterns complementary to the template. Protocells with sufficiently high growth or replication rates are not only stable against Ostwald ripening, but are also predicted to undergo spontaneous division through a shape instability. This would mark a key step in the emergence of minimal cells and open the way for the evolution of more complex life-like systems.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DYNAGROW" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DYNAGROW" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DINAMIX (2019)

Real-time diffusion NMR analysis of mixtures

Read More  

AdjustNet (2020)

Self-Adjusting Networks

Read More  

CohoSing (2019)

Cohomology and Singularities

Read More