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SYNVIVO SIGNED

Revealing dendritic cell-CD4+ T cell communication by using synthetic biology in vivo

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SYNVIVO project word cloud

Explore the words cloud of the SYNVIVO project. It provides you a very rough idea of what is the project "SYNVIVO" about.

proinflammatory    time    governing    easily    dc    tolerance    contact    technologies    fates    limited    cells    polarizations    place    interaction    clones    clearance    combined    migratory    pairs    interactions    history    relies    understand    label    pathogen    despite    engineered    followed    suppress    designed    types    takes    genetically    programs    compartment    differentiation    effector    decision    priming    dcs    dendritic    molecular    na    instruct    polarization    resident    immune    showing    reaction    toward    enzymatic    heterogeneous    iuml    proliferation    inflammation    exchanged    labeling    receptor    revealed    identity    implementing    reporter    characterization    antigen    messages    perform    direct    innovative    lipstic    harmful    ad    cell    multitude    flow    sortase    functions    mediated    activation    biological    hoc    fate    first    populations    undergo    ve    ligand    cd4    vivo    cytometry    tags    detected    enzyme    specialized    signals   

Project "SYNVIVO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 1˙500˙000.00

Map

 Project objective

CD4 T cells are crucial component of our immune system: they support distinct types of proinflammatory responses key for pathogen clearance, maintain tolerance and suppress harmful inflammation. To perform this multitude of functions, naïve CD4 T cells first undergo activation through direct contact with dendritic cells (DCs), a highly heterogeneous compartment including several populations of migratory and resident cells. These interactions lead to selection of antigen specific T cell clones, followed by their proliferation and differentiation into distinct subsets showing specialized effector programs or polarizations. Despite the essential role of dendritic cells in the activation and polarization of naïve CD4 T cells, we have limited information available on both the identity of DC involved in priming and the molecular messages exchanged upon DC-CD4 T cell interaction in different types of response. Recently, I developed an innovative technology that allows us for the first time to label interactions between immune cells in vivo. This method, which we called LIPSTIC, relies on the labeling of genetically engineered receptor–ligand pairs mediated by the enzyme Sortase A. After the enzymatic reaction takes place in vivo, the history of ligand–receptor interactions is revealed by the presence of reporter tags easily detected by flow cytometry. This proposal aims to determine how interactions between dendritic cells and T cells instruct CD4 T cells toward distinct fates using LIPSTIC and by implementing other technologies designed ad hoc to measure and understand the biological consequences of relevant cell-cell interactions on T cell fate decision. The combined approaches described here will contribute to the characterization of the molecular signals governing CD4 T cell response in vivo.

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The information about "SYNVIVO" are provided by the European Opendata Portal: CORDIS opendata.

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