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CollectiveDynamics SIGNED

Collective signaling oscillations in embryonic patterning – revealing underlying principles

Total Cost €

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EC-Contrib. €

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Partnership

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 CollectiveDynamics project word cloud

Explore the words cloud of the CollectiveDynamics project. It provides you a very rough idea of what is the project "CollectiveDynamics" about.

axis    discovery    collective    cells    linked    conceptually    oscillation    wnt    et    outlined    fish    tsiairis    oscillatory    psm    fundamental    model    waves    wave    versatile    position    central    embryos    expand    patterns    period    mesoderm    principles    emergence    decode    previously    timing    questions    signaling    fgf    line    machinery    erc    sweep    embryo    underlying    2018    sonnen    discoveries    display    first    phenomenon    functional    quantitative    palmeirim    perturbations    mouse    dynamics    proper    entrain    shown    vivo    hours    notch    expertise    segmentation    embryonic    aulehla    governed    optogenetics       entrainment    made    vitro    ways    builds    combine    1997    emergent    medaka    signalling    al    yield    2016    molecular    vertebrate    patterning    oscillations    clock    periodically    precise    genetic    critical    assays    strategy    time    presomitic    significance    relative    experimental    synchronization    periodic   

Project "CollectiveDynamics" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙153˙310 €
 EC max contribution 2˙153˙310 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

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# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 2˙153˙310.00

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 Project objective

In this proposal, we study collective signaling oscillations during embryonic patterning. Signaling oscillations during vertebrate embryo segmentation are governed by a molecular oscillatory machinery referred to as segmentation clock (Palmeirim et al., 1997). The segmentation clock is linked to periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells (period~2 hours in mouse embryos). Importantly, PSM cells display complex, collective synchronization and, as a result, wave-like activity patterns (phase waves) sweep periodically along the embryonic axis. We have previously shown that phase waves are an emergent and collective phenomenon in PSM cells (Tsiairis and Aulehla, 2016). Conceptually, this proposal builds on our previous discovery that the relative timing between Wnt/Notch oscillations is critical for proper mesoderm patterning (Sonnen et al., 2018). What are the principles underlying the emergence of collective synchronization and how do PSM cells decode relative timing of signalling oscillations? As outlined in this proposal, we are now in a unique position to address these fundamental questions in novel ways. Importantly, we have established an entrainment strategy that enables, for the first time, precise experimental control of oscillation dynamics (Sonnen et al., 2018). Our strategy is to further expand the entrainment approach, including the future use of optogenetics, and also combine it with our expertise in quantitative, multi-scale analysis of signalling dynamics and functional, genetic perturbations. A central aim of this ERC proposal is to build on discoveries made in versatile in vitro assays that we developed and to address their significance in vivo. To this end, we propose a novel line of research using the medaka fish model. We will entrain and challenge collective synchronization in vivo to address how signalling oscillations are integrated with growth dynamics to yield robust embryonic patterning.

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