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CollectiveDynamics SIGNED

Collective signaling oscillations in embryonic patterning – revealing underlying principles

Total Cost €

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EC-Contrib. €

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Partnership

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 CollectiveDynamics project word cloud

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governed    fgf    emergence    wave    perturbations    clock    vivo    phenomenon    line    functional    oscillations    display    synchronization    assays    fish    patterns    et    significance    vitro       segmentation    genetic    signaling    machinery    outlined    aulehla    time    central    presomitic    erc    al    embryonic    entrainment    2016    quantitative    periodically    medaka    period    decode    expertise    molecular    builds    2018    mouse    previously    dynamics    oscillatory    yield    experimental    made    questions    cells    fundamental    ways    sweep    signalling    first    patterning    expand    tsiairis    embryo    relative    palmeirim    discoveries    principles    shown    critical    collective    axis    waves    vertebrate    entrain    proper    notch    combine    conceptually    embryos    1997    oscillation    sonnen    underlying    hours    wnt    timing    linked    position    model    precise    versatile    emergent    optogenetics    periodic    psm    mesoderm    discovery    strategy   

Project "CollectiveDynamics" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙153˙310 €
 EC max contribution 2˙153˙310 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 2˙153˙310.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

In this proposal, we study collective signaling oscillations during embryonic patterning. Signaling oscillations during vertebrate embryo segmentation are governed by a molecular oscillatory machinery referred to as segmentation clock (Palmeirim et al., 1997). The segmentation clock is linked to periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells (period~2 hours in mouse embryos). Importantly, PSM cells display complex, collective synchronization and, as a result, wave-like activity patterns (phase waves) sweep periodically along the embryonic axis. We have previously shown that phase waves are an emergent and collective phenomenon in PSM cells (Tsiairis and Aulehla, 2016). Conceptually, this proposal builds on our previous discovery that the relative timing between Wnt/Notch oscillations is critical for proper mesoderm patterning (Sonnen et al., 2018). What are the principles underlying the emergence of collective synchronization and how do PSM cells decode relative timing of signalling oscillations? As outlined in this proposal, we are now in a unique position to address these fundamental questions in novel ways. Importantly, we have established an entrainment strategy that enables, for the first time, precise experimental control of oscillation dynamics (Sonnen et al., 2018). Our strategy is to further expand the entrainment approach, including the future use of optogenetics, and also combine it with our expertise in quantitative, multi-scale analysis of signalling dynamics and functional, genetic perturbations. A central aim of this ERC proposal is to build on discoveries made in versatile in vitro assays that we developed and to address their significance in vivo. To this end, we propose a novel line of research using the medaka fish model. We will entrain and challenge collective synchronization in vivo to address how signalling oscillations are integrated with growth dynamics to yield robust embryonic patterning.

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