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CollectiveDynamics SIGNED

Collective signaling oscillations in embryonic patterning – revealing underlying principles

Total Cost €

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EC-Contrib. €

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Partnership

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 CollectiveDynamics project word cloud

Explore the words cloud of the CollectiveDynamics project. It provides you a very rough idea of what is the project "CollectiveDynamics" about.

clock    embryonic    proper    presomitic    periodically    dynamics    oscillation    2018    decode    critical    underlying    erc    discovery    position    segmentation    linked    strategy    principles    hours    functional    2016    synchronization    phenomenon    entrain    sonnen    cells    time    genetic    machinery    perturbations    sweep    al    assays    embryo    oscillations    wave    questions    molecular    relative    versatile    previously    central    discoveries    oscillatory    expertise    governed       embryos    patterns    shown    aulehla    entrainment    line    yield    waves    tsiairis    conceptually    made    axis    builds    outlined    first    optogenetics    signalling    significance    fish    combine    fundamental    palmeirim    mouse    vivo    wnt    timing    quantitative    precise    medaka    ways    patterning    experimental    et    psm    emergent    collective    mesoderm    display    1997    vitro    periodic    emergence    period    vertebrate    notch    expand    fgf    model    signaling   

Project "CollectiveDynamics" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙153˙310 €
 EC max contribution 2˙153˙310 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

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# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 2˙153˙310.00

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 Project objective

In this proposal, we study collective signaling oscillations during embryonic patterning. Signaling oscillations during vertebrate embryo segmentation are governed by a molecular oscillatory machinery referred to as segmentation clock (Palmeirim et al., 1997). The segmentation clock is linked to periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells (period~2 hours in mouse embryos). Importantly, PSM cells display complex, collective synchronization and, as a result, wave-like activity patterns (phase waves) sweep periodically along the embryonic axis. We have previously shown that phase waves are an emergent and collective phenomenon in PSM cells (Tsiairis and Aulehla, 2016). Conceptually, this proposal builds on our previous discovery that the relative timing between Wnt/Notch oscillations is critical for proper mesoderm patterning (Sonnen et al., 2018). What are the principles underlying the emergence of collective synchronization and how do PSM cells decode relative timing of signalling oscillations? As outlined in this proposal, we are now in a unique position to address these fundamental questions in novel ways. Importantly, we have established an entrainment strategy that enables, for the first time, precise experimental control of oscillation dynamics (Sonnen et al., 2018). Our strategy is to further expand the entrainment approach, including the future use of optogenetics, and also combine it with our expertise in quantitative, multi-scale analysis of signalling dynamics and functional, genetic perturbations. A central aim of this ERC proposal is to build on discoveries made in versatile in vitro assays that we developed and to address their significance in vivo. To this end, we propose a novel line of research using the medaka fish model. We will entrain and challenge collective synchronization in vivo to address how signalling oscillations are integrated with growth dynamics to yield robust embryonic patterning.

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