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CollectiveDynamics SIGNED

Collective signaling oscillations in embryonic patterning – revealing underlying principles

Total Cost €

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EC-Contrib. €

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Partnership

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 CollectiveDynamics project word cloud

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machinery    vitro    al    synchronization    previously    underlying    vertebrate    functional    hours    entrain    molecular       builds    decode    emergence    oscillation    strategy    fish    axis    critical    mouse    precise    medaka    oscillations    clock    relative    versatile    principles    sweep    cells    periodic    waves    position    signalling    fundamental    psm    discoveries    2016    governed    model    proper    notch    presomitic    periodically    perturbations    oscillatory    optogenetics    embryos    embryo    linked    yield    period    expertise    sonnen    genetic    aulehla    combine    dynamics    central    patterns    emergent    experimental    entrainment    mesoderm    collective    made    quantitative    patterning    2018    first    shown    conceptually    time    outlined    segmentation    ways    erc    display    wnt    discovery    et    signaling    questions    embryonic    timing    phenomenon    significance    expand    assays    1997    palmeirim    tsiairis    fgf    line    vivo    wave   

Project "CollectiveDynamics" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙153˙310 €
 EC max contribution 2˙153˙310 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

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# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 2˙153˙310.00

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 Project objective

In this proposal, we study collective signaling oscillations during embryonic patterning. Signaling oscillations during vertebrate embryo segmentation are governed by a molecular oscillatory machinery referred to as segmentation clock (Palmeirim et al., 1997). The segmentation clock is linked to periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells (period~2 hours in mouse embryos). Importantly, PSM cells display complex, collective synchronization and, as a result, wave-like activity patterns (phase waves) sweep periodically along the embryonic axis. We have previously shown that phase waves are an emergent and collective phenomenon in PSM cells (Tsiairis and Aulehla, 2016). Conceptually, this proposal builds on our previous discovery that the relative timing between Wnt/Notch oscillations is critical for proper mesoderm patterning (Sonnen et al., 2018). What are the principles underlying the emergence of collective synchronization and how do PSM cells decode relative timing of signalling oscillations? As outlined in this proposal, we are now in a unique position to address these fundamental questions in novel ways. Importantly, we have established an entrainment strategy that enables, for the first time, precise experimental control of oscillation dynamics (Sonnen et al., 2018). Our strategy is to further expand the entrainment approach, including the future use of optogenetics, and also combine it with our expertise in quantitative, multi-scale analysis of signalling dynamics and functional, genetic perturbations. A central aim of this ERC proposal is to build on discoveries made in versatile in vitro assays that we developed and to address their significance in vivo. To this end, we propose a novel line of research using the medaka fish model. We will entrain and challenge collective synchronization in vivo to address how signalling oscillations are integrated with growth dynamics to yield robust embryonic patterning.

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