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Demos SIGNED

Design Principles of Branching Morphogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Demos project word cloud

Explore the words cloud of the Demos project. It provides you a very rough idea of what is the project "Demos" about.

extensive    classes    organ    paradigmatic    dynamics    events    understand    characterizing    emergent    subcellular    quantitative    structure    behaviours    optimal    kidney    theoretical    developmental    lung    branched    bi    broad    physiological    morphogenetic    cells    extract    rules    groups    mechanical    predictions    goals    remodelling    contrast    combining    multiple    position    principles    theory    gland    question    give    cell    puts    biophysical    datasets    generate    driving    stem    biology    relevance    pattern    scales    organs    tools    choices    directional    entails    analytical    cytoskeletal    morphogenesis    progenitor    function    branching    numerical    organogenesis    forces    data    impose    mechanisms    niche    tackle    mammary    fascinating    mechanochemical    combine    molecular    fundamental    tests    published    bridging    computational    feedbacks    cellular    fate    signals    constraints    length    mechanics    outputs    insights    experimental    prostate    compare    global    stochastic    chemical   

Project "Demos" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙452˙604 €
 EC max contribution 1˙452˙604 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙452˙604.00

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 Project objective

Branching morphogenesis, the process by which branched organs such as the lung, prostate, kidney or mammary gland are generated, is a paradigmatic example of complex developmental processes bridging multiple scales. The mechanisms through which given molecular signals and cellular behaviours give rise to a robust organ structure remains a fundamental and open question, for which theoretical methods are needed. Our experience in modelling cytoskeletal mechanics, stem cell dynamics and branching processes puts us in a unique position to tackle this fascinating problem, by combining systems biology and biophysical approaches at multiple scales. In particular, we will focus on:

1. Understanding how stochastic rules lead to robust morphogenetic outputs at the organ scale, and which constraints and optimal design principles they impose on physiological function. 2. Characterizing at the cellular scale the bi-directional feedbacks coordinating fate choices of stem/progenitor cells and niche signals during the extensive remodelling events that branching morphogenesis entails. 3. Developing at the subcellular and cellular scale an integrated mechanochemical theory of pattern formation in branched organs, to understand the coordination of mechanical forces and chemical signals defining their global structure.

Towards these goals, we will combine analytical and numerical tools with data analysis methods, to reach a quantitative understanding of the emergent mechanisms driving branching morphogenesis. We will challenge our theoretical predictions with published datasets available for different organs, as well as design specific experimental tests in collaboration with experimental biology groups. This will allow us to compare and contrast different systems, and extract generic classes of design principles of organogenesis across length scales. With this, we expect to generate novel insights of broad relevance for the fields of systems, computational and developmental biology.

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The information about "DEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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