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Demos SIGNED

Design Principles of Branching Morphogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Demos project word cloud

Explore the words cloud of the Demos project. It provides you a very rough idea of what is the project "Demos" about.

organogenesis    biology    relevance    fascinating    data    fundamental    contrast    kidney    multiple    directional    pattern    mammary    predictions    quantitative    morphogenetic    extract    global    physiological    compare    optimal    theoretical    paradigmatic    computational    characterizing    bi    constraints    numerical    question    choices    cells    organ    tests    combining    stochastic    emergent    insights    progenitor    gland    position    goals    forces    rules    driving    niche    classes    tools    analytical    generate    prostate    outputs    mechanisms    tackle    mechanochemical    length    subcellular    signals    entails    biophysical    dynamics    remodelling    fate    feedbacks    principles    experimental    combine    cytoskeletal    theory    events    groups    developmental    branched    structure    cell    impose    morphogenesis    molecular    published    extensive    cellular    bridging    mechanics    scales    understand    branching    function    mechanical    puts    stem    datasets    behaviours    organs    give    chemical    broad    lung   

Project "Demos" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙452˙604 €
 EC max contribution 1˙452˙604 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙452˙604.00

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 Project objective

Branching morphogenesis, the process by which branched organs such as the lung, prostate, kidney or mammary gland are generated, is a paradigmatic example of complex developmental processes bridging multiple scales. The mechanisms through which given molecular signals and cellular behaviours give rise to a robust organ structure remains a fundamental and open question, for which theoretical methods are needed. Our experience in modelling cytoskeletal mechanics, stem cell dynamics and branching processes puts us in a unique position to tackle this fascinating problem, by combining systems biology and biophysical approaches at multiple scales. In particular, we will focus on:

1. Understanding how stochastic rules lead to robust morphogenetic outputs at the organ scale, and which constraints and optimal design principles they impose on physiological function. 2. Characterizing at the cellular scale the bi-directional feedbacks coordinating fate choices of stem/progenitor cells and niche signals during the extensive remodelling events that branching morphogenesis entails. 3. Developing at the subcellular and cellular scale an integrated mechanochemical theory of pattern formation in branched organs, to understand the coordination of mechanical forces and chemical signals defining their global structure.

Towards these goals, we will combine analytical and numerical tools with data analysis methods, to reach a quantitative understanding of the emergent mechanisms driving branching morphogenesis. We will challenge our theoretical predictions with published datasets available for different organs, as well as design specific experimental tests in collaboration with experimental biology groups. This will allow us to compare and contrast different systems, and extract generic classes of design principles of organogenesis across length scales. With this, we expect to generate novel insights of broad relevance for the fields of systems, computational and developmental biology.

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The information about "DEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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