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Demos SIGNED

Design Principles of Branching Morphogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Demos project word cloud

Explore the words cloud of the Demos project. It provides you a very rough idea of what is the project "Demos" about.

optimal    fundamental    pattern    molecular    computational    signals    constraints    generate    global    scales    mechanical    organogenesis    physiological    events    subcellular    organs    length    driving    puts    tests    outputs    compare    principles    mechanochemical    groups    dynamics    stem    paradigmatic    prostate    developmental    fate    structure    datasets    relevance    cell    tools    progenitor    biology    fascinating    numerical    combining    theoretical    contrast    biophysical    goals    directional    cytoskeletal    emergent    characterizing    combine    branching    give    quantitative    morphogenesis    extensive    niche    function    bridging    cells    tackle    mechanisms    lung    mechanics    theory    feedbacks    published    rules    predictions    insights    organ    experimental    broad    branched    data    chemical    impose    cellular    mammary    multiple    remodelling    bi    entails    stochastic    question    gland    classes    choices    kidney    morphogenetic    behaviours    forces    extract    analytical    understand    position   

Project "Demos" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙452˙604 €
 EC max contribution 1˙452˙604 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙452˙604.00

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 Project objective

Branching morphogenesis, the process by which branched organs such as the lung, prostate, kidney or mammary gland are generated, is a paradigmatic example of complex developmental processes bridging multiple scales. The mechanisms through which given molecular signals and cellular behaviours give rise to a robust organ structure remains a fundamental and open question, for which theoretical methods are needed. Our experience in modelling cytoskeletal mechanics, stem cell dynamics and branching processes puts us in a unique position to tackle this fascinating problem, by combining systems biology and biophysical approaches at multiple scales. In particular, we will focus on:

1. Understanding how stochastic rules lead to robust morphogenetic outputs at the organ scale, and which constraints and optimal design principles they impose on physiological function. 2. Characterizing at the cellular scale the bi-directional feedbacks coordinating fate choices of stem/progenitor cells and niche signals during the extensive remodelling events that branching morphogenesis entails. 3. Developing at the subcellular and cellular scale an integrated mechanochemical theory of pattern formation in branched organs, to understand the coordination of mechanical forces and chemical signals defining their global structure.

Towards these goals, we will combine analytical and numerical tools with data analysis methods, to reach a quantitative understanding of the emergent mechanisms driving branching morphogenesis. We will challenge our theoretical predictions with published datasets available for different organs, as well as design specific experimental tests in collaboration with experimental biology groups. This will allow us to compare and contrast different systems, and extract generic classes of design principles of organogenesis across length scales. With this, we expect to generate novel insights of broad relevance for the fields of systems, computational and developmental biology.

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The information about "DEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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