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Demos SIGNED

Design Principles of Branching Morphogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Demos project word cloud

Explore the words cloud of the Demos project. It provides you a very rough idea of what is the project "Demos" about.

niche    molecular    fate    cytoskeletal    quantitative    compare    morphogenetic    mechanochemical    stochastic    contrast    biology    numerical    tests    lung    length    impose    extract    characterizing    data    classes    cells    biophysical    question    organ    puts    bi    predictions    cell    theory    branching    constraints    extensive    global    prostate    goals    dynamics    tackle    feedbacks    insights    published    signals    analytical    kidney    emergent    mammary    multiple    mechanical    computational    cellular    physiological    pattern    driving    give    groups    progenitor    behaviours    directional    choices    relevance    understand    optimal    morphogenesis    generate    experimental    events    scales    fascinating    broad    subcellular    outputs    datasets    mechanisms    theoretical    entails    remodelling    fundamental    principles    chemical    branched    organs    bridging    rules    position    paradigmatic    mechanics    gland    developmental    structure    stem    tools    function    forces    organogenesis    combine    combining   

Project "Demos" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙452˙604 €
 EC max contribution 1˙452˙604 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙452˙604.00

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 Project objective

Branching morphogenesis, the process by which branched organs such as the lung, prostate, kidney or mammary gland are generated, is a paradigmatic example of complex developmental processes bridging multiple scales. The mechanisms through which given molecular signals and cellular behaviours give rise to a robust organ structure remains a fundamental and open question, for which theoretical methods are needed. Our experience in modelling cytoskeletal mechanics, stem cell dynamics and branching processes puts us in a unique position to tackle this fascinating problem, by combining systems biology and biophysical approaches at multiple scales. In particular, we will focus on:

1. Understanding how stochastic rules lead to robust morphogenetic outputs at the organ scale, and which constraints and optimal design principles they impose on physiological function. 2. Characterizing at the cellular scale the bi-directional feedbacks coordinating fate choices of stem/progenitor cells and niche signals during the extensive remodelling events that branching morphogenesis entails. 3. Developing at the subcellular and cellular scale an integrated mechanochemical theory of pattern formation in branched organs, to understand the coordination of mechanical forces and chemical signals defining their global structure.

Towards these goals, we will combine analytical and numerical tools with data analysis methods, to reach a quantitative understanding of the emergent mechanisms driving branching morphogenesis. We will challenge our theoretical predictions with published datasets available for different organs, as well as design specific experimental tests in collaboration with experimental biology groups. This will allow us to compare and contrast different systems, and extract generic classes of design principles of organogenesis across length scales. With this, we expect to generate novel insights of broad relevance for the fields of systems, computational and developmental biology.

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The information about "DEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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