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MEPHOS SIGNED

Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 MEPHOS project word cloud

Explore the words cloud of the MEPHOS project. It provides you a very rough idea of what is the project "MEPHOS" about.

chemokine    microplates    biological    aging    assays    viscoelastic    clinical    2026    realizing    approved    market    synovial    technologies    preclinical    trauma       rational    rising    bone    single    vitro    context    industrial    replacement    secondments    translational    curing       options    modulating    ambition    burden    hydrogel    consequently    spark    culture    hit    models    symptoms    academic    degeneration    adults    clinic    sustainably    simultaneously    osteoarthritis    vesicles    documents    mechanical    characterization    chronic    translation    weeks    training    biologicals    people    instil    2016    upls    oa    scientists    pharmacological    cell    interdisciplinary    extracellular    option    small    geometry    disability    fabrication    older    cartilage    release    gender    disease    pain    subchondral    joint    obesity    mephos    upl    polymeric    boundaries    ultimately    inhibitors    intersectoral    course    deposition    risk    fluid    million    strategy    bridge    sophisticated    halt    match    articular    stem    metalloproteinase    inclusion    stanford    rationally    molecules    action    continues    clinically    tissue    societal    treatment    billion    sole    predicted    regeneration    glycoproteins    sme   

Project "MEPHOS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 952˙200 €
 EC max contribution 864˙800 € (91%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 312˙800.00
2    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) participant 253˙000.00
3    UNIVERSIDADE DO MINHO PT (BRAGA) participant 225˙400.00
4    LIPOCURE LTD IL (JERUSALEM) participant 73˙600.00
5    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00
6    THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL US (CHAPEL HILL) partner 0.00
7    University of Arkansas US (Fayetteville) partner 0.00
8    VANDERBILT UNIVERSITY US (NASHVILLE TENESSEE) partner 0.00

Map

 Project objective

Osteoarthritis (OA) is a chronic disease involving the degeneration of articular cartilage and subchondral bone. It represents the single most common cause of disability in older adults. Being aging, obesity, trauma and gender risk factors for OA, its societal burden is rapidly rising. Across EU, over 40 million people are affected by OA. Current treatment options aim at modulating the symptoms rather than curing this chronic disease. Consequently, joint replacement continues to be ultimately the sole option. In this context, MEPHOS aims at realizing an integrated strategy for OA treatment based on the intra-articular deposition of hydrogel, polymeric microplates (uPLs) that could simultaneously provide a long-term pharmacological action and mechanical support. To this end, the uPL geometry and mechanical properties will be rationally selected to match the viscoelastic behaviour of cartilage and synovial fluid. Over the course of several weeks, uPLs will sustainably release clinically-approved molecules for pain management and novel small molecules and biologicals; including chemokine and metalloproteinase inhibitors to halt tissue degeneration; glycoproteins, growth factors and stem cell-derived extracellular vesicles to favour tissue regeneration. MEPHOS involves three EU Academic Institutions and a SME for uPL fabrication, and four US Academic Institutions for uPL biological and preclinical characterization. Through interdisciplinary and intersectoral secondments, this project will support the training of EU scientists on sophisticated in-vitro assays and three different preclinical OA models; foster the rational development of uPLs; and instil a translational research culture to bridge preclinical-clinical boundaries. The inclusion of a SME and the Stanford SPARK Translation program documents MEPHOS ambition to develop technologies that could hit the clinic and an industrial market, which is predicted to growth from $1.6 billion in 2016 to $3.5 billion by 2026.

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The information about "MEPHOS" are provided by the European Opendata Portal: CORDIS opendata.

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