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MEPHOS SIGNED

Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 MEPHOS project word cloud

Explore the words cloud of the MEPHOS project. It provides you a very rough idea of what is the project "MEPHOS" about.

polymeric    scientists    cell    small    translation    replacement    ultimately    pharmacological    sophisticated    treatment    stem    older    articular    clinical       societal    curing    mechanical    microplates    modulating    options    bridge    continues    strategy    halt    metalloproteinase    osteoarthritis    characterization    upls    synovial    fabrication    biological    disease    tissue    degeneration    consequently    geometry    people    release    pain    rationally    obesity    molecules    rational    billion    technologies    realizing    biologicals    match    models    2026    bone    stanford    instil    documents       trauma    inclusion    risk    fluid    boundaries    single    training    disability    upl    viscoelastic    action    clinic    course    context    vesicles    chemokine    million    preclinical    academic    gender    vitro    clinically    sme    assays    simultaneously    extracellular    spark    adults    mephos    burden    sustainably    sole    hydrogel    intersectoral    option    2016    inhibitors    interdisciplinary    rising    secondments    translational    chronic    deposition    culture    symptoms    industrial    approved    regeneration    oa    ambition    joint    aging    predicted    market    glycoproteins    cartilage    hit    weeks    subchondral   

Project "MEPHOS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 952˙200 €
 EC max contribution 864˙800 € (91%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 312˙800.00
2    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) participant 253˙000.00
3    UNIVERSIDADE DO MINHO PT (BRAGA) participant 225˙400.00
4    LIPOCURE LTD IL (JERUSALEM) participant 73˙600.00
5    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00
6    THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL US (CHAPEL HILL) partner 0.00
7    University of Arkansas US (Fayetteville) partner 0.00
8    VANDERBILT UNIVERSITY US (NASHVILLE TENESSEE) partner 0.00

Map

 Project objective

Osteoarthritis (OA) is a chronic disease involving the degeneration of articular cartilage and subchondral bone. It represents the single most common cause of disability in older adults. Being aging, obesity, trauma and gender risk factors for OA, its societal burden is rapidly rising. Across EU, over 40 million people are affected by OA. Current treatment options aim at modulating the symptoms rather than curing this chronic disease. Consequently, joint replacement continues to be ultimately the sole option. In this context, MEPHOS aims at realizing an integrated strategy for OA treatment based on the intra-articular deposition of hydrogel, polymeric microplates (uPLs) that could simultaneously provide a long-term pharmacological action and mechanical support. To this end, the uPL geometry and mechanical properties will be rationally selected to match the viscoelastic behaviour of cartilage and synovial fluid. Over the course of several weeks, uPLs will sustainably release clinically-approved molecules for pain management and novel small molecules and biologicals; including chemokine and metalloproteinase inhibitors to halt tissue degeneration; glycoproteins, growth factors and stem cell-derived extracellular vesicles to favour tissue regeneration. MEPHOS involves three EU Academic Institutions and a SME for uPL fabrication, and four US Academic Institutions for uPL biological and preclinical characterization. Through interdisciplinary and intersectoral secondments, this project will support the training of EU scientists on sophisticated in-vitro assays and three different preclinical OA models; foster the rational development of uPLs; and instil a translational research culture to bridge preclinical-clinical boundaries. The inclusion of a SME and the Stanford SPARK Translation program documents MEPHOS ambition to develop technologies that could hit the clinic and an industrial market, which is predicted to growth from $1.6 billion in 2016 to $3.5 billion by 2026.

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The information about "MEPHOS" are provided by the European Opendata Portal: CORDIS opendata.

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