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MEPHOS SIGNED

Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 MEPHOS project word cloud

Explore the words cloud of the MEPHOS project. It provides you a very rough idea of what is the project "MEPHOS" about.

curing    pain    market    clinically    fluid       scientists       ambition    metalloproteinase    polymeric    stem    pharmacological    bridge    intersectoral    single    extracellular    technologies    realizing    biological    course    halt    subchondral    chronic    vitro    academic    bone    risk    small    culture    fabrication    microplates    sophisticated    mephos    rationally    training    obesity    glycoproteins    symptoms    joint    simultaneously    societal    adults    options    upls    oa    translational    translation    predicted    sustainably    hydrogel    models    characterization    weeks    vesicles    inhibitors    replacement    sole    mechanical    stanford    inclusion    2026    interdisciplinary    clinical    context    rising    consequently    continues    instil    older    deposition    option    molecules    aging    tissue    regeneration    cartilage    action    industrial    trauma    million    osteoarthritis    documents    degeneration    upl    articular    burden    gender    treatment    hit    biologicals    chemokine    viscoelastic    boundaries    clinic    modulating    strategy    people    cell    disability    release    spark    secondments    geometry    assays    approved    rational    synovial    disease    2016    match    billion    preclinical    ultimately    sme   

Project "MEPHOS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 952˙200 €
 EC max contribution 864˙800 € (91%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 312˙800.00
2    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) participant 253˙000.00
3    UNIVERSIDADE DO MINHO PT (BRAGA) participant 225˙400.00
4    LIPOCURE LTD IL (JERUSALEM) participant 73˙600.00
5    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00
6    THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL US (CHAPEL HILL) partner 0.00
7    University of Arkansas US (Fayetteville) partner 0.00
8    VANDERBILT UNIVERSITY US (NASHVILLE TENESSEE) partner 0.00

Map

 Project objective

Osteoarthritis (OA) is a chronic disease involving the degeneration of articular cartilage and subchondral bone. It represents the single most common cause of disability in older adults. Being aging, obesity, trauma and gender risk factors for OA, its societal burden is rapidly rising. Across EU, over 40 million people are affected by OA. Current treatment options aim at modulating the symptoms rather than curing this chronic disease. Consequently, joint replacement continues to be ultimately the sole option. In this context, MEPHOS aims at realizing an integrated strategy for OA treatment based on the intra-articular deposition of hydrogel, polymeric microplates (uPLs) that could simultaneously provide a long-term pharmacological action and mechanical support. To this end, the uPL geometry and mechanical properties will be rationally selected to match the viscoelastic behaviour of cartilage and synovial fluid. Over the course of several weeks, uPLs will sustainably release clinically-approved molecules for pain management and novel small molecules and biologicals; including chemokine and metalloproteinase inhibitors to halt tissue degeneration; glycoproteins, growth factors and stem cell-derived extracellular vesicles to favour tissue regeneration. MEPHOS involves three EU Academic Institutions and a SME for uPL fabrication, and four US Academic Institutions for uPL biological and preclinical characterization. Through interdisciplinary and intersectoral secondments, this project will support the training of EU scientists on sophisticated in-vitro assays and three different preclinical OA models; foster the rational development of uPLs; and instil a translational research culture to bridge preclinical-clinical boundaries. The inclusion of a SME and the Stanford SPARK Translation program documents MEPHOS ambition to develop technologies that could hit the clinic and an industrial market, which is predicted to growth from $1.6 billion in 2016 to $3.5 billion by 2026.

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The information about "MEPHOS" are provided by the European Opendata Portal: CORDIS opendata.

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