Explore the words cloud of the AND-PD project. It provides you a very rough idea of what is the project "AND-PD" about.
The following table provides information about the project.
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
|Coordinator Country||Spain [ES]|
|Total cost||5˙995˙848 €|
|EC max contribution||5˙995˙848 € (100%)|
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|Duration (year-month-day)||from 2020-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||coordinator||630˙906.00|
|2||KAROLINSKA INSTITUTET||SE (STOCKHOLM)||participant||1˙058˙867.00|
|3||FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA||IT (GENOVA)||participant||820˙976.00|
|4||KING'S COLLEGE LONDON||UK (LONDON)||participant||748˙286.00|
|5||Motac France||FR (Floirac)||participant||690˙735.00|
|6||THE HEBREW UNIVERSITY OF JERUSALEM||IL (JERUSALEM)||participant||531˙372.00|
|7||UNIVERSITE DE BORDEAUX||FR (BORDEAUX)||participant||531˙250.00|
|8||UNIVERSITY COLLEGE LONDON||UK (LONDON)||participant||448˙984.00|
|9||TRANSINE THERAPEUTICS LIMITED||UK (ROYSTON)||participant||250˙000.00|
|10||MODUS RESEARCH AND INNOVATION LIMITED||UK (EDINBURGH)||participant||153˙845.00|
|11||FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA||ES (PAMPLONA)||participant||130˙625.00|
AND-PD investigates causative mechanisms of anxiety (with or without depression) as a non-motor co-morbidity of PD. The central hypothesis posits that degeneration of dopaminergic neurons in the dorsal raphe nucleus (DRN) affects the activity of serotonergic cells which could alter DRN microcircuit and neurotransmission to target brain regions encoding for emotional valence. Dysfunction of DRN circuits and aberrant assignment of emotional valence, secondary to dopamine loss in the DRN of PD patients, may underlie PD-related anxiety. Using models of mental comorbidities of PD, AND-PD will investigate functional changes in the DRN-striatal circuits and establish the link between anxiety phenotype and degeneration of dopaminergic neurons in the DRN. Findings will be used to inform pre-clinical (rodent, non-human primate and biobank samples) and clinical research (fMRI and PET imaging, behavioural analysis, retrospective cohort analysis) to identify and correlate causalities between dysfunctional DRN activity and co-morbid anxiety of PD. To prove causality, AND-PD will i) analyse anxiety in neurotoxin and genetic models of PD; ii) assess the physiological impact and behavioural effects of interventions that selectively reproduce the damage caused by PD in the DRN; and iii) determine the ability of RNA based approaches targeting the DRN to counteract anxiety associated with PD. To demonstrate the link in human patients, AND-PD will analyse patient databases and correlate measures of anxiety with: 1) signs of neuropathology in PD brain samples’ DRN and 2) clinical and functional biomarkers of dopamine and serotonergic function through DRN imaging in patients. AND-PD beneficiaries’ experience in translational research will help ‘bridge the gap’ between preclinical and clinical experiments and help identify new anatomical targets and markers (molecular, functional and pathological,) to support better diagnosis, management and treatment of co-morbidities in PD patients.
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