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AND-PD SIGNED

COMORBIDITY MECHANISMS OF ANXIETY AND PARKINSON’S DISEASE

Total Cost €

0

EC-Contrib. €

0

Partnership

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 AND-PD project word cloud

Explore the words cloud of the AND-PD project. It provides you a very rough idea of what is the project "AND-PD" about.

reproduce    dopamine    encoding    pathological    beneficiaries    imaging    models    biobank    degeneration    prove    anatomical    central    human    clinical    drn    neurotoxin    depression    rna    nucleus    serotonergic    experiments    biomarkers    neuropathology    phenotype    morbidity    inform    retrospective    signs    pd    cells    counteract    causality    cohort    valence    aberrant    dysfunctional    emotional    morbid    brain    translational    rodent    caused    interventions    bridge    co    secondary    causalities    function    assignment    circuits    anxiety    physiological    selectively    morbidities    mental    investigates    posits    functional    samples    molecular    damage    dopaminergic    mechanisms    motor    primate    regions    patients    gap    databases    diagnosis    neurons    raphe    preclinical    treatment    behavioural    dysfunction    alter    link    hypothesis    correlate    markers    underlie    genetic    comorbidities    patient    microcircuit    striatal    fmri    dorsal    pet    causative    neurotransmission   

Project "AND-PD" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 5˙995˙848 €
 EC max contribution 5˙995˙848 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 630˙906.00
2    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 1˙058˙867.00
3    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 820˙976.00
4    KING'S COLLEGE LONDON UK (LONDON) participant 748˙286.00
5    Motac France FR (Floirac) participant 690˙735.00
6    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) participant 531˙372.00
7    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 531˙250.00
8    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 448˙984.00
9    TRANSINE THERAPEUTICS LIMITED UK (ROYSTON) participant 250˙000.00
10    MODUS RESEARCH AND INNOVATION LIMITED UK (EDINBURGH) participant 153˙845.00
11    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) participant 130˙625.00

Map

 Project objective

AND-PD investigates causative mechanisms of anxiety (with or without depression) as a non-motor co-morbidity of PD. The central hypothesis posits that degeneration of dopaminergic neurons in the dorsal raphe nucleus (DRN) affects the activity of serotonergic cells which could alter DRN microcircuit and neurotransmission to target brain regions encoding for emotional valence. Dysfunction of DRN circuits and aberrant assignment of emotional valence, secondary to dopamine loss in the DRN of PD patients, may underlie PD-related anxiety. Using models of mental comorbidities of PD, AND-PD will investigate functional changes in the DRN-striatal circuits and establish the link between anxiety phenotype and degeneration of dopaminergic neurons in the DRN. Findings will be used to inform pre-clinical (rodent, non-human primate and biobank samples) and clinical research (fMRI and PET imaging, behavioural analysis, retrospective cohort analysis) to identify and correlate causalities between dysfunctional DRN activity and co-morbid anxiety of PD. To prove causality, AND-PD will i) analyse anxiety in neurotoxin and genetic models of PD; ii) assess the physiological impact and behavioural effects of interventions that selectively reproduce the damage caused by PD in the DRN; and iii) determine the ability of RNA based approaches targeting the DRN to counteract anxiety associated with PD. To demonstrate the link in human patients, AND-PD will analyse patient databases and correlate measures of anxiety with: 1) signs of neuropathology in PD brain samples’ DRN and 2) clinical and functional biomarkers of dopamine and serotonergic function through DRN imaging in patients. AND-PD beneficiaries’ experience in translational research will help ‘bridge the gap’ between preclinical and clinical experiments and help identify new anatomical targets and markers (molecular, functional and pathological,) to support better diagnosis, management and treatment of co-morbidities in PD patients.

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