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AND-PD SIGNED

COMORBIDITY MECHANISMS OF ANXIETY AND PARKINSON’S DISEASE

Total Cost €

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EC-Contrib. €

0

Partnership

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 AND-PD project word cloud

Explore the words cloud of the AND-PD project. It provides you a very rough idea of what is the project "AND-PD" about.

causalities    retrospective    posits    pet    secondary    physiological    counteract    biomarkers    translational    striatal    raphe    comorbidities    neurons    fmri    rna    biobank    genetic    phenotype    alter    databases    neuropathology    diagnosis    mental    beneficiaries    dorsal    rodent    nucleus    investigates    valence    damage    selectively    anxiety    emotional    aberrant    hypothesis    dysfunctional    inform    drn    patients    preclinical    neurotransmission    degeneration    dopamine    dopaminergic    gap    molecular    signs    pd    mechanisms    functional    cells    causative    morbidities    correlate    brain    co    central    clinical    anatomical    samples    markers    experiments    caused    interventions    causality    encoding    underlie    bridge    depression    microcircuit    reproduce    circuits    function    cohort    morbidity    pathological    models    link    prove    regions    imaging    patient    neurotoxin    assignment    motor    human    dysfunction    treatment    primate    behavioural    morbid    serotonergic   

Project "AND-PD" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 5˙995˙848 €
 EC max contribution 5˙995˙848 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 630˙906.00
2    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 1˙058˙867.00
3    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 820˙976.00
4    KING'S COLLEGE LONDON UK (LONDON) participant 748˙286.00
5    Motac France FR (Floirac) participant 690˙735.00
6    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) participant 531˙372.00
7    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 531˙250.00
8    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 448˙984.00
9    TRANSINE THERAPEUTICS LIMITED UK (ROYSTON) participant 250˙000.00
10    MODUS RESEARCH AND INNOVATION LIMITED UK (EDINBURGH) participant 153˙845.00
11    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) participant 130˙625.00

Map

 Project objective

AND-PD investigates causative mechanisms of anxiety (with or without depression) as a non-motor co-morbidity of PD. The central hypothesis posits that degeneration of dopaminergic neurons in the dorsal raphe nucleus (DRN) affects the activity of serotonergic cells which could alter DRN microcircuit and neurotransmission to target brain regions encoding for emotional valence. Dysfunction of DRN circuits and aberrant assignment of emotional valence, secondary to dopamine loss in the DRN of PD patients, may underlie PD-related anxiety. Using models of mental comorbidities of PD, AND-PD will investigate functional changes in the DRN-striatal circuits and establish the link between anxiety phenotype and degeneration of dopaminergic neurons in the DRN. Findings will be used to inform pre-clinical (rodent, non-human primate and biobank samples) and clinical research (fMRI and PET imaging, behavioural analysis, retrospective cohort analysis) to identify and correlate causalities between dysfunctional DRN activity and co-morbid anxiety of PD. To prove causality, AND-PD will i) analyse anxiety in neurotoxin and genetic models of PD; ii) assess the physiological impact and behavioural effects of interventions that selectively reproduce the damage caused by PD in the DRN; and iii) determine the ability of RNA based approaches targeting the DRN to counteract anxiety associated with PD. To demonstrate the link in human patients, AND-PD will analyse patient databases and correlate measures of anxiety with: 1) signs of neuropathology in PD brain samples’ DRN and 2) clinical and functional biomarkers of dopamine and serotonergic function through DRN imaging in patients. AND-PD beneficiaries’ experience in translational research will help ‘bridge the gap’ between preclinical and clinical experiments and help identify new anatomical targets and markers (molecular, functional and pathological,) to support better diagnosis, management and treatment of co-morbidities in PD patients.

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