4-IN THE LUNG RUN SIGNED
4-IN THE LUNG RUN: towards INdividually tailored INvitations, screening INtervals, and INtegrated co-morbidity reducing strategies in lung cancer screening
Total Cost €
0EC-Contrib. €
0Partnership
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04-IN THE LUNG RUN project word cloud
Explore the words cloud of the 4-IN THE LUNG RUN project. It provides you a very rough idea of what is the project "4-IN THE LUNG RUN" about.
Project "4-IN THE LUNG RUN" data sheet
The following table provides information about the project.
| Coordinator |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 7˙999˙948 € |
| EC max contribution | 7˙999˙948 € (100%) |
| Programme |
1. H2020-EU.3.1.2. (Preventing disease) |
| Code Call | H2020-SC1-2019-Two-Stage-RTD |
| Funding Scheme | RIA |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2024-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM | NL (ROTTERDAM) | coordinator | 1˙926˙250.00 |
| 2 | INSTITUTE FOR DIAGNOSTIC ACCURACY RESEARCH BV | NL (GRONINGEN) | participant | 1˙901˙500.00 |
| 3 | FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI | IT (Milan) | participant | 1˙398˙500.00 |
| 4 | DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG | DE (HEIDELBERG) | participant | 677˙443.00 |
| 5 | THE UNIVERSITY OF NOTTINGHAM | UK (NOTTINGHAM) | participant | 591˙240.00 |
| 6 | INSTITUT CATALA D'ONCOLOGIA | ES (L'HOSPITALET DEL LLOBREGAT) | participant | 526˙575.00 |
| 7 | INSTITUT GUSTAVE ROUSSY | FR (VILLEJUIF) | participant | 425˙750.00 |
| 8 | UNIVERSITAETSKLINIKUM ESSEN | DE (ESSEN) | participant | 368˙470.00 |
| 9 | UNIVERSITY COLLEGE LONDON | UK (LONDON) | participant | 184˙220.00 |
Map
Project objective
With 338,000 EU-deaths annually, lung cancer is a devastating problem. CT screening has the potential to prevent ten-thousands of lung cancer deaths annually. The positive results of the Dutch-Belgian screening trial (NELSON), with relatively low referral rates, and the NLST in the USA provided conclusive evidence. However, implementation is likely to be limited, slow and of variable quality throughout Europe, and current guidelines could easily require up to 25 million CT screens annually. The most optimal strategy in risk-based lung-thoracic screening is still unknown regarding the optimal and most cost-effective (e.g., targeted) strategy 1) to recruit, 2) to integrate smoking cessation and co-morbidity-reducing services, and 3) to determine the (risk-based) screening interval. Personalised regimens based on the baseline CT result can potentially retain 85% of the mortality reduction achievable through screening at 45% less screens, thus potentially saving much unnecessary harm associated with screening, and 0.5-1 billion Euros per year. The heart of 4-IN-THE-LUNG-RUN is a randomised controlled trial amongst 24,000 individuals evaluating whether it is safe to have risk-based less intensive screening intervals after a negative baseline CT. Various methods to improve participation of hard-to-reach individuals will be assessed in five different healthcare settings. Innovative co-morbidity reducing strategies will be tested including other markers on CT imaging, as Calcium Score and COPD. Cost impact and cost-effectiveness analyses using a natural history model will steer implementation. The experienced consortium will strongly interact with key stakeholders, and discuss interim results with key other international initiatives on CT screening, biomarkers, and smoking cessation practices. This proposal will form the evidence base for risk-based lung cancer screening with huge benefits for the EU, on health outcomes, cost savings, and innovation in the long run.
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