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4-IN THE LUNG RUN SIGNED

4-IN THE LUNG RUN: towards INdividually tailored INvitations, screening INtervals, and INtegrated co-morbidity reducing strategies in lung cancer screening

Total Cost €

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EC-Contrib. €

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Partnership

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4-IN THE LUNG RUN project word cloud

Explore the words cloud of the 4-IN THE LUNG RUN project. It provides you a very rough idea of what is the project "4-IN THE LUNG RUN" about.

potentially markers recruit morbidity discuss saving healthcare participation reducing risk 85 with benefits cessation form outcomes interact amongst 338 strategies heart smoking co run baseline cancer screening regimens conclusive easily strategy intervals intensive negative innovative international quality regarding steer safe lung million interim settings prevent natural tested services positive rates hard individuals interval billion copd nlst 45 health imaging stakeholders slow savings effectiveness personalised nelson referral score 24 usa unnecessary relatively screens biomarkers retain practices huge thoracic 25 trial integrate optimal model guidelines annually thousands randomised devastating ct calcium mortality ten limited dutch achievable base deaths harm history innovation unknown euros belgian

Project "4-IN THE LUNG RUN" data sheet

The following table provides information about the project.

Coordinator	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	7˙999˙948 €
EC max contribution	7˙999˙948 € (100%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2024-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	coordinator	1˙926˙250.00
2	INSTITUTE FOR DIAGNOSTIC ACCURACY RESEARCH BV INSTITUTE FOR DIAGNOSTIC ACCURACY RESEARCH BV Organization address address: PROFESSOR ENNO DIRK WIERSMASTRAAT 5 city: GRONINGEN postcode: 9713 GH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	1˙901˙500.00
3	FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI Organization address address: Via Venezian 1 city: Milan postcode: 20133 website: www.istitutotumori.mi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Milan)	participant	1˙398˙500.00
4	DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 280 city: HEIDELBERG postcode: 69120 website: www.dkfz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	677˙443.00
5	THE UNIVERSITY OF NOTTINGHAM THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	591˙240.00
6	INSTITUT CATALA D'ONCOLOGIA INSTITUT CATALA D'ONCOLOGIA Organization address address: AV GRAN VIA DE L'HOSPITALET 199-203 city: L'HOSPITALET DEL LLOBREGAT postcode: 8908 website: www.iconcologia.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (L'HOSPITALET DEL LLOBREGAT)	participant	526˙575.00
7	INSTITUT GUSTAVE ROUSSY INSTITUT GUSTAVE ROUSSY Organization address address: Rue Camille Desmoulins 39 city: VILLEJUIF postcode: 94805 website: http://www.igr.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	425˙750.00
8	UNIVERSITAETSKLINIKUM ESSEN UNIVERSITAETSKLINIKUM ESSEN Organization address address: HUFELANDSTRASSE 55 city: ESSEN postcode: 45147 website: www.uk-essen.de/frauenklinik/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ESSEN)	participant	368˙470.00
9	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	184˙220.00

Map

Project objective

With 338,000 EU-deaths annually, lung cancer is a devastating problem. CT screening has the potential to prevent ten-thousands of lung cancer deaths annually. The positive results of the Dutch-Belgian screening trial (NELSON), with relatively low referral rates, and the NLST in the USA provided conclusive evidence. However, implementation is likely to be limited, slow and of variable quality throughout Europe, and current guidelines could easily require up to 25 million CT screens annually. The most optimal strategy in risk-based lung-thoracic screening is still unknown regarding the optimal and most cost-effective (e.g., targeted) strategy 1) to recruit, 2) to integrate smoking cessation and co-morbidity-reducing services, and 3) to determine the (risk-based) screening interval. Personalised regimens based on the baseline CT result can potentially retain 85% of the mortality reduction achievable through screening at 45% less screens, thus potentially saving much unnecessary harm associated with screening, and 0.5-1 billion Euros per year. The heart of 4-IN-THE-LUNG-RUN is a randomised controlled trial amongst 24,000 individuals evaluating whether it is safe to have risk-based less intensive screening intervals after a negative baseline CT. Various methods to improve participation of hard-to-reach individuals will be assessed in five different healthcare settings. Innovative co-morbidity reducing strategies will be tested including other markers on CT imaging, as Calcium Score and COPD. Cost impact and cost-effectiveness analyses using a natural history model will steer implementation. The experienced consortium will strongly interact with key stakeholders, and discuss interim results with key other international initiatives on CT screening, biomarkers, and smoking cessation practices. This proposal will form the evidence base for risk-based lung cancer screening with huge benefits for the EU, on health outcomes, cost savings, and innovation in the long run.

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