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Opendata, web and dolomites

SENATOR TERMINATED

Staff Exchange for Novel applications in 19f magnetic resonance imaging

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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SENATOR project word cloud

Explore the words cloud of the SENATOR project. It provides you a very rough idea of what is the project "SENATOR" about.

molecular gbca imaging gadolinium accumulate patients therapeutic diagnostic until repeated opened technique migration basis biomaterial safety functionalisation reagents quantitative trafficking spurred professionals renal nanoparticles contrast administered mri historically move tissue clinical imaged resolution cell signatures competing incorporated impairment accumulated gbcas tolerated visualised modality brain generally area materials risk individual tissues released mounting agents door living 2015 whilst structures found smart novelty regarding surrounding ligands body healthcare limit biology multifunctional kidneys absolutely discrimination situations labelled cells signal fda insights magnetic invasive resonance animals bone 19f deemed deposits payload preclinical perfluorocarbon generation background advised expansion safe inside active announcement

Project "SENATOR" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	1˙541˙000 €
EC max contribution	1˙541˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2019
Funding Scheme	MSCA-RISE
Starting year	2020
Duration (year-month-day)	from 2020-05-01 to 2024-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	234˙600.00
2	PERCUROS BV PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	202˙400.00
3	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	165˙600.00
4	UNIVERSITA DEGLI STUDI DI CAMERINO UNIVERSITA DEGLI STUDI DI CAMERINO Organization address address: PIAZZA CAVOUR 19F city: CAMERINO postcode: 62032 website: www.unicam.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CAMERINO)	participant	161˙000.00
5	TECOBIOSCIENCES GMBH TECOBIOSCIENCES GMBH Organization address address: HABICHTSTRASSE 21 city: LANDSHUT postcode: 84036 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LANDSHUT)	participant	156˙400.00
6	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Organization address address: CORSO UMBERTO I, 40 city: NAPOLI postcode: 80138 website: www.unina.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NAPOLI)	participant	156˙400.00
7	MEDRES-MEDICAL RESEARCH GMBH MEDRES-MEDICAL RESEARCH GMBH Organization address address: GLEUELER STRASSE 50 city: KOLN postcode: 50931 website: www.medres.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOLN)	participant	147˙200.00
8	HEINRICH-HEINE-UNIVERSITAET DUESSELDORF HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Organization address address: UNIVERSITAETSSTRASSE 1 city: DUSSELDORF postcode: 40225 website: www.uni-duesseldorf.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUSSELDORF)	participant	110˙400.00
9	GOOD BIOMARKER SCIENCES BV GOOD BIOMARKER SCIENCES BV Organization address address: TEIJLINGERLAAN 59 city: SASSENHEIM postcode: 2171 CD website: www.gbsleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (SASSENHEIM)	participant	82˙800.00
10	PROGREDUM GMBH PROGREDUM GMBH Organization address address: OTTERBERGER STRASSE 73 city: KAISERSLAUTERN postcode: 67659 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KAISERSLAUTERN)	participant	82˙800.00
11	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	41˙400.00

Map

Project objective

Magnetic resonance imaging (MRI) is a leading clinical diagnostic technique, which is able to provide whole body imaging, and when individual cells are imaged in living animals, it can provide new insights into the biology of cell trafficking and migration. For cells to be visualised by MRI, they generally must be labelled to enable their discrimination from surrounding tissue. The development of magnetic resonance imaging (MRI) contrast agents is therefore an active area of research, where the basis for this interest is the expansion of MRI as a high-resolution and non-invasive important preclinical and clinical imaging modality. Moreover, there are now new opportunities to developing smart materials with multifunctional abilities including MRI contrast in-built within biomaterial structures, functionalisation with targeting ligands and the carrying of a therapeutic payload. This move towards a new generation of MRI contrast reagents has also been spurred on by the mounting evidence against gadolinium-based contrast agents (GBCAs). They are currently the agents of choice and were considered historically safe and well tolerated until recently. However, they have been found to accumulate in various tissues of patients who do not have renal impairment, including bone, brain and kidneys. Furthermore, in 2015, the FDA released a new safety announcement regarding GBCAs and the risk of accumulated deposits in the brain following repeated use. Whilst GBCAs are being investigated, they can still be administered but healthcare professionals have been advised to limit the use of GBCA to situations in which contrast is deemed absolutely necessary.This has opened the door to the novelty of using perfluorocarbon (19F) being incorporated inside smart nanoparticles, which can offer unique quantitative signatures for molecular MRI with no competing background signal.

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The information about "SENATOR" are provided by the European Opendata Portal: CORDIS opendata.

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