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OLI.VAS SIGNED

The Oligo-Vascular interface: understanding its properties and functions

Total Cost €

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EC-Contrib. €

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Partnership

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 OLI.VAS project word cloud

Explore the words cloud of the OLI.VAS project. It provides you a very rough idea of what is the project "OLI.VAS" about.

pathology    complementary    vasculature    cns    genetics    biology    successful    little    vessels    breakthroughs    disease    culture    oligodendrocytes    fails    vivo    tracks    ms    severe    vas    relationship    ol    remyelination    tackle    vascular    oligo    tissue    myelin    regulators    central    multidisciplinary    regulator    ex    modulating    pursued    edge    area    bioinformatics    combine    oligodendrocyte    proper    patients    ols    samples    cell    patient    blood    insights    mechanisms    indicates    disrupted    existence    generation    innovative    3d    transcriptomics    600000    spatial    hypothesis    outcome    treatments    lesions    white    reconstructing    interface    cells    diseases    sclerosis    re    depends    nutrients    multiple    oxygen    crosstalk    oli    lacking    lineage    function    cutting    despite    delivering    glia    active    track    interaction    prevent    vitro    imaging    unravel    myelination    mechanistic    substantial    nervous    apart    oligodendrogenesis    scientific    mouse    deconstructing    single    supports    generate    organ    demyelinating    de   

Project "OLI.VAS" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 2˙000˙000.00

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 Project objective

Oligodendrocytes (OLs) are the glia cells that produce myelin in the central nervous system (CNS). Despite the severe outcome of demyelinating diseases, like multiple sclerosis (MS), little is known about the mechanisms by which myelin is disrupted or why remyelination fails in disease. Thus, a substantial advance in the understanding of oligodendrocyte biology and myelin pathology is required in order to develop successful treatments for demyelinating diseases. Recent research indicates that apart from delivering oxygen and nutrients, blood vessels are active regulators of organ function. Our recent work supports the existence of an oligo-vascular interface where vessels directly control oligodendrogenesis. However, mechanistic insights of the interaction between OLs and the vasculature are lacking. Based on the innovative hypothesis that proper generation and OL functionality depends on active crosstalk with the vasculature, the OLI.VAS project will now tackle the challenge to characterize in depth the interaction between OLs and the vasculature during development and demyelinating diseases. To achieve this goal, two complementary multidisciplinary research tracks are pursued: Research track 1: Deconstructing and reconstructing the oligo-vascular interface to unravel the relationship of oligodendrocyte lineage cells with the vasculature Research track 2: Studying the oligo-vascular interface in white matter lesions. Modulating the vasculature to prevent de-myelination or promote of re-myelination Both tracks combine cutting edge technology in single cell and spatial transcriptomics, bioinformatics, 3D imaging, in vitro and ex vivo tissue culture, mouse genetics and MS patient samples. OLI.VAS will deliver new insights into the role of the vasculature as a regulator of oligodendrogenesis and myelination and thus generate major scientific breakthroughs in an area that is highly relevant for diseases such as MS, which affects more than 600000 patients in Europe.

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The information about "OLI.VAS" are provided by the European Opendata Portal: CORDIS opendata.

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