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OLI.VAS SIGNED

The Oligo-Vascular interface: understanding its properties and functions

Total Cost €

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EC-Contrib. €

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Partnership

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 OLI.VAS project word cloud

Explore the words cloud of the OLI.VAS project. It provides you a very rough idea of what is the project "OLI.VAS" about.

pathology    samples    cutting    ol    ex    3d    existence    vivo    transcriptomics    pursued    demyelinating    treatments    delivering    vitro    tissue    generate    genetics    re    regulators    proper    oligodendrocytes    edge    complementary    cell    depends    generation    cns    patients    oxygen    outcome    function    modulating    vessels    culture    biology    nervous    track    blood    multiple    spatial    fails    600000    lacking    scientific    oligo    vas    reconstructing    severe    successful    tracks    white    oligodendrocyte    glia    lineage    vasculature    insights    myelin    myelination    sclerosis    ols    vascular    oligodendrogenesis    little    despite    multidisciplinary    supports    interaction    relationship    nutrients    indicates    area    combine    cells    central    disease    bioinformatics    tackle    remyelination    organ    diseases    deconstructing    interface    unravel    mechanisms    de    ms    patient    substantial    lesions    disrupted    prevent    hypothesis    breakthroughs    single    mouse    mechanistic    imaging    crosstalk    apart    active    oli    regulator    innovative   

Project "OLI.VAS" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 2˙000˙000.00

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 Project objective

Oligodendrocytes (OLs) are the glia cells that produce myelin in the central nervous system (CNS). Despite the severe outcome of demyelinating diseases, like multiple sclerosis (MS), little is known about the mechanisms by which myelin is disrupted or why remyelination fails in disease. Thus, a substantial advance in the understanding of oligodendrocyte biology and myelin pathology is required in order to develop successful treatments for demyelinating diseases. Recent research indicates that apart from delivering oxygen and nutrients, blood vessels are active regulators of organ function. Our recent work supports the existence of an oligo-vascular interface where vessels directly control oligodendrogenesis. However, mechanistic insights of the interaction between OLs and the vasculature are lacking. Based on the innovative hypothesis that proper generation and OL functionality depends on active crosstalk with the vasculature, the OLI.VAS project will now tackle the challenge to characterize in depth the interaction between OLs and the vasculature during development and demyelinating diseases. To achieve this goal, two complementary multidisciplinary research tracks are pursued: Research track 1: Deconstructing and reconstructing the oligo-vascular interface to unravel the relationship of oligodendrocyte lineage cells with the vasculature Research track 2: Studying the oligo-vascular interface in white matter lesions. Modulating the vasculature to prevent de-myelination or promote of re-myelination Both tracks combine cutting edge technology in single cell and spatial transcriptomics, bioinformatics, 3D imaging, in vitro and ex vivo tissue culture, mouse genetics and MS patient samples. OLI.VAS will deliver new insights into the role of the vasculature as a regulator of oligodendrogenesis and myelination and thus generate major scientific breakthroughs in an area that is highly relevant for diseases such as MS, which affects more than 600000 patients in Europe.

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The information about "OLI.VAS" are provided by the European Opendata Portal: CORDIS opendata.

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