Opendata, web and dolomites

ASTRA SIGNED

ASsembly and phase Transitions of Ribonucleoprotein Aggregates in neurons: from physiology to pathology.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ASTRA project word cloud

Explore the words cloud of the ASTRA project. It provides you a very rough idea of what is the project "ASTRA" about.

induce    defective    solid    appearance    misfolding    rnps    plan    ribonucleoprotein    genuine    sorting    cells    team    retina    sophisticated    tools    dynamic    unravel    computational    proteins    pathogenic    indicate    disease    powerful    protein    events    animal    relevance    act    gain    aberrant    intracellular    indicates    recent    imaging    neurons    motor    assembly    plays    life    microscopy    separate    modifications    rbps    genetic    assemblies    altered    neurodegeneration    localization    vitro    lateral    amyotrophic    vivo    components    explore    tissues    cytoplasmic    therapeutic    models    effort    reveal    impede    post    works    liquid    interdisciplinary    composition    neurodegenerative    astra    rbp    cascades    unsolved    rnas    transition    molecules    architecture    form    strategies    dysfunction    biophysical    scaffolding    rna    combine    diseases    monitor    rnp    metabolism    translational    optical    purification    phases    physiological    modified    link    mutations    function    integral    binding    innovative    complexes    coding    trigger    sclerosis    pathological   

Project "ASTRA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA 

Organization address
address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185
website: www.uniroma1.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 7˙741˙799 €
 EC max contribution 7˙741˙799 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2026-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) coordinator 2˙735˙625.00
2    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 5˙006˙173.00

Map

 Project objective

Recent works indicate the pathogenic relevance of altered RNA metabolism and aberrant ribonucleoprotein (RNP) assembly in several neurodegenerative diseases, such as Amyotrophic lateral sclerosis. How defective RNPs form, what are their integral components and which events trigger their appearance late in life are still unsolved issues. While emerging evidence indicates that mutations and post-translational modifications of specific RNA-binding proteins (RBPs) induce liquid-solid phase transition in vitro, much less is known about the in vivo properties of RNP assemblies and which role RNA plays in their formation. ASTRA will combine sophisticated imaging-derived RNP complex purification with innovative computational approaches and powerful genetic tools to unravel the biophysical properties and composition of RBP complexes and how they are modified in disease conditions. Through the development of new imaging and optical methods we plan to study how RNPs separate in liquid and solid phases in cells, in tissues (retina) and animal models and to characterize their RNA and protein components in physiological and pathological states. Exploiting the novel finding that non-coding RNAs act as scaffolding molecules for RNP assembly, we will investigate how such RNAs control the dynamic link between RNP formation, intracellular sorting and function. In a genuine interdisciplinary team effort, we will reveal how the architecture and localization of cytoplasmic RNP complexes are controlled in motor neurons and affected in neurodegeneration. We plan to develop novel advanced microscopy methods to monitor formation of aberrant RNPs in vivo and we will explore new molecules to impede pathological cascades driven by RNP assemblies. In conclusion, ASTRA will allow us to gain a comprehensive understanding of RNP function and dysfunction; we will use this knowledge to develop new therapeutic strategies that will impact on several protein-misfolding neurodegenerative diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ASTRA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ASTRA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More