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IC-CCD-qHSC SIGNED

Intrapopulation communication and collective cell decisions of hematopoietic stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IC-CCD-qHSC project word cloud

Explore the words cloud of the IC-CCD-qHSC project. It provides you a very rough idea of what is the project "IC-CCD-qHSC" about.

regulation    deep    moment    neighborhoods    date    contributes    anatomical    tightly    hematopoietic    preserve    frequencies    customized    stem    metabolomic    vast    showing    hscs    dependencies    molecular    tend    tools    competition    compensate    exit    few    individual    cluster    postnatal    functional    embryonic    image    microscopy    postulate    profiling    death    forms    rare    homeostasis    self    differentiation    active    quiescent    collective    broad    adult    local    suffices    regions    basal    synchronously    function    majority    proliferation    heterogeneity    tissue    regulated    single    behavior    accumulate    pool    preliminary    learning    multidisciplinary    orchestrate    pipeline    perceive    adulthood    basic    interplay    maintenance    triggers    life    hsc    renewing    cycle    expand    homeostatic    blood    cells    crosstalk    relatively    quorum    heterogeneous    spatial    despite    sensing    substantially    continuous    unravel    organization    proliferative    coordinated    marrow    bone    bm    stages    cellular    transcriptomics    3d    unknown    statistics    found    proximal    convert    rates    combines    cell    entry    densities    mechanisms   

Project "IC-CCD-qHSC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙312˙500 €
 EC max contribution 2˙312˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 2˙312˙500.00

Map

 Project objective

Hematopoietic stem cells (HSCs) contribute to blood cell production throughout life and are found at rare, yet tightly regulated frequencies in adult bone marrow (BM). During embryonic and postnatal development, HSCs expand through continuous self-renewing proliferation. Upon entry into adulthood the vast majority of HSCs synchronously convert to a quiescent state. From then on, at any given moment very few HSCs are found in active stages of cell cycle, which suffices to compensate basal HSC loss due to differentiation or cell death. Since proliferation rates of individual HSCs are heterogeneous, entry and exit from cell cycle need to be coordinated at the level of the HSC pool. To date, the mechanisms that orchestrate this collective proliferative behavior and effectively control the maintenance of homeostatic HSC numbers remain unknown. In preliminary work for this project we have customized a pipeline that combines 3D microscopy, deep learning-based image analysis and spatial statistics. Using these tools, we observed that despite showing broad spatial heterogeneity, HSCs tend to cluster and accumulate in relatively large regions of the BM. We now postulate that molecular crosstalk between proximal HSCs enables them to perceive their local densities and triggers collective regulation of HSC function to preserve homeostasis. Through a multidisciplinary approach involving high-level microscopy, spatial analyses, comprehensive metabolomic profiling and single-cell transcriptomics we aim to 1) characterize the basic anatomical and functional features of spatial dependencies between HSCs 2) study the potential role of quorum-sensing mechanisms in HSC crosstalk and 3) investigate if competition for molecular resources in local neighborhoods contributes to maintenance of HSC homeostasis. Our research has the potential to unravel novel complex forms of cellular interplay and substantially advance our understanding of hematopoietic tissue organization.

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The information about "IC-CCD-QHSC" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-18 15:57:31) correctly updated