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IC-CCD-qHSC SIGNED

Intrapopulation communication and collective cell decisions of hematopoietic stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IC-CCD-qHSC project word cloud

Explore the words cloud of the IC-CCD-qHSC project. It provides you a very rough idea of what is the project "IC-CCD-qHSC" about.

orchestrate    adult    3d    cell    compensate    quorum    vast    perceive    accumulate    transcriptomics    regions    tools    life    bm    collective    stages    interplay    microscopy    expand    heterogeneous    pipeline    proliferative    postulate    majority    broad    forms    synchronously    proliferation    differentiation    neighborhoods    individual    unravel    continuous    bone    postnatal    showing    cycle    preserve    contributes    preliminary    hscs    heterogeneity    cluster    tend    unknown    regulated    metabolomic    crosstalk    image    dependencies    embryonic    basal    hsc    customized    spatial    behavior    mechanisms    renewing    convert    regulation    coordinated    hematopoietic    frequencies    self    statistics    sensing    multidisciplinary    cellular    local    substantially    competition    homeostasis    deep    marrow    anatomical    entry    blood    triggers    proximal    homeostatic    date    cells    functional    stem    function    adulthood    learning    single    despite    tissue    moment    molecular    maintenance    quiescent    rates    organization    few    suffices    combines    profiling    exit    death    relatively    rare    basic    densities    found    pool    active    tightly   

Project "IC-CCD-qHSC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙312˙500 €
 EC max contribution 2˙312˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 2˙312˙500.00

Map

 Project objective

Hematopoietic stem cells (HSCs) contribute to blood cell production throughout life and are found at rare, yet tightly regulated frequencies in adult bone marrow (BM). During embryonic and postnatal development, HSCs expand through continuous self-renewing proliferation. Upon entry into adulthood the vast majority of HSCs synchronously convert to a quiescent state. From then on, at any given moment very few HSCs are found in active stages of cell cycle, which suffices to compensate basal HSC loss due to differentiation or cell death. Since proliferation rates of individual HSCs are heterogeneous, entry and exit from cell cycle need to be coordinated at the level of the HSC pool. To date, the mechanisms that orchestrate this collective proliferative behavior and effectively control the maintenance of homeostatic HSC numbers remain unknown. In preliminary work for this project we have customized a pipeline that combines 3D microscopy, deep learning-based image analysis and spatial statistics. Using these tools, we observed that despite showing broad spatial heterogeneity, HSCs tend to cluster and accumulate in relatively large regions of the BM. We now postulate that molecular crosstalk between proximal HSCs enables them to perceive their local densities and triggers collective regulation of HSC function to preserve homeostasis. Through a multidisciplinary approach involving high-level microscopy, spatial analyses, comprehensive metabolomic profiling and single-cell transcriptomics we aim to 1) characterize the basic anatomical and functional features of spatial dependencies between HSCs 2) study the potential role of quorum-sensing mechanisms in HSC crosstalk and 3) investigate if competition for molecular resources in local neighborhoods contributes to maintenance of HSC homeostasis. Our research has the potential to unravel novel complex forms of cellular interplay and substantially advance our understanding of hematopoietic tissue organization.

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The information about "IC-CCD-QHSC" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-11-30 13:34:32) correctly updated