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TGF-BTB SIGNED

Transforming Growth Factor – Bench To Bedside. Towards a better understanding of TGF-β isoform specific signalling in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TGF-BTB project word cloud

Explore the words cloud of the TGF-BTB project. It provides you a very rough idea of what is the project "TGF-BTB" about.

ladbury    btb    biophysical    implicated    silico    cellular    complete    ukasz    tgf    immunotherapies    prof    interplay    caroline    microenvironment    university    beta    fellow    researcher    innovative    course    data    employ    cancers    cancer    anticancer    transforming    critical    john    dysregulation    avenues    hinck    disorders    discovering    exploring    join    crick    connective    tumor    initiation    andrew    shutdown    forefront    molecular    receptors    developmental    return    treating    significance    signalling    secondment    human    explore    tools    signaling    cell    pittsburgh    isoforms    group    biology    excessive    progression    laboratory    special    responsible    tissue    bedside    engineered    outcomes    peptide    class    simulations    outgoing    therapeutic    dr    soft    protein    diseases    understand    family    hill    inhibitors    mechanistic    francis    structural    fibrotic    world    isoform    roles    manipulate    wieteska    basic    cytokines    leeds    pathogenesis    bench    continue    canonical    benefit   

Project "TGF-BTB" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 271˙732 €
 EC max contribution 271˙732 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 271˙732.00
2    UNIVERSITY OF PITTSBURGH US (PITTSBURGH) partner 0.00

Map

 Project objective

TGF-BTB (Transforming Growth Factor – Bench To Bedside) is an ambitious and innovative project, the goal of which is to not only to understand the different roles of the TGF-β isoforms as well as in cell signalling at a molecular level, but also to explore their critical roles implicated in pathogenesis of fibrotic disorders and cancer. The dysregulation or complete shutdown of TGF-β pathway is responsible for many human diseases including connective tissue disorders, fibrotic disorders and the initiation and progression of soft tissue cancers. Most recent data show the importance of TGF-β in controlling the tumor microenvironment and its significance in the course of anticancer immunotherapies. The project will employ methods of structural and cell biology, together with in silico simulations, and will include the development of new tools, such as isoform-specific peptide-based inhibitors, engineered cytokines to study and manipulate the TGF-β canonical and non-canonical pathways. TGF-BTB is not only of great importance for increasing basic mechanistic understanding of TGF-β signalling, but also in terms of discovering potential new therapeutic avenues for treating diseases driven by excessive TGF-b signaling. During the outgoing phase, The Fellow, Dr Łukasz Wieteska, will join Prof Andrew Hinck’s research group at the University of Pittsburgh, which is a world class research laboratory at the forefront of TGF-β family structural studies. the Fellow will return to the University of Leeds to continue his work with Prof John Ladbury, whose research has a strong focus on exploring the structural, biophysical, and cellular outcomes of the interplay of protein receptors in cell signalling pathways. Upon return, the Fellow will also benefit from a secondment at The Francis Crick Institute in the laboratory of Dr Caroline Hill, a leading researcher in the field of developmental biology with a special focus on TGF-β signaling.

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The information about "TGF-BTB" are provided by the European Opendata Portal: CORDIS opendata.

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