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Transforming Growth Factor – Bench To Bedside. Towards a better understanding of TGF-β isoform specific signalling in health and disease

Total Cost €


EC-Contrib. €






 TGF-BTB project word cloud

Explore the words cloud of the TGF-BTB project. It provides you a very rough idea of what is the project "TGF-BTB" about.

canonical    structural    excessive    protein    fibrotic    signaling    ladbury    understand    peptide    laboratory    progression    crick    initiation    soft    isoform    outgoing    inhibitors    silico    fellow    outcomes    tumor    btb    cell    beta    human    treating    critical    bedside    biophysical    pittsburgh    tgf    dysregulation    john    roles    manipulate    significance    discovering    anticancer    hinck    microenvironment    ukasz    andrew    innovative    cancers    isoforms    wieteska    molecular    cancer    prof    pathogenesis    tissue    explore    class    therapeutic    simulations    secondment    disorders    avenues    complete    forefront    employ    leeds    responsible    exploring    return    caroline    transforming    world    cellular    developmental    dr    engineered    join    shutdown    connective    immunotherapies    special    data    implicated    course    receptors    diseases    signalling    group    cytokines    researcher    university    benefit    continue    basic    mechanistic    biology    hill    francis    family    tools    bench    interplay   

Project "TGF-BTB" data sheet

The following table provides information about the project.


Organization address
city: LEEDS
postcode: LS2 9JT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 271˙732 €
 EC max contribution 271˙732 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2023-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 271˙732.00


 Project objective

TGF-BTB (Transforming Growth Factor – Bench To Bedside) is an ambitious and innovative project, the goal of which is to not only to understand the different roles of the TGF-β isoforms as well as in cell signalling at a molecular level, but also to explore their critical roles implicated in pathogenesis of fibrotic disorders and cancer. The dysregulation or complete shutdown of TGF-β pathway is responsible for many human diseases including connective tissue disorders, fibrotic disorders and the initiation and progression of soft tissue cancers. Most recent data show the importance of TGF-β in controlling the tumor microenvironment and its significance in the course of anticancer immunotherapies. The project will employ methods of structural and cell biology, together with in silico simulations, and will include the development of new tools, such as isoform-specific peptide-based inhibitors, engineered cytokines to study and manipulate the TGF-β canonical and non-canonical pathways. TGF-BTB is not only of great importance for increasing basic mechanistic understanding of TGF-β signalling, but also in terms of discovering potential new therapeutic avenues for treating diseases driven by excessive TGF-b signaling. During the outgoing phase, The Fellow, Dr Łukasz Wieteska, will join Prof Andrew Hinck’s research group at the University of Pittsburgh, which is a world class research laboratory at the forefront of TGF-β family structural studies. the Fellow will return to the University of Leeds to continue his work with Prof John Ladbury, whose research has a strong focus on exploring the structural, biophysical, and cellular outcomes of the interplay of protein receptors in cell signalling pathways. Upon return, the Fellow will also benefit from a secondment at The Francis Crick Institute in the laboratory of Dr Caroline Hill, a leading researcher in the field of developmental biology with a special focus on TGF-β signaling.

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The information about "TGF-BTB" are provided by the European Opendata Portal: CORDIS opendata.

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