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TGF-BTB SIGNED

Transforming Growth Factor – Bench To Bedside. Towards a better understanding of TGF-β isoform specific signalling in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TGF-BTB project word cloud

Explore the words cloud of the TGF-BTB project. It provides you a very rough idea of what is the project "TGF-BTB" about.

course    explore    tumor    exploring    outgoing    isoforms    immunotherapies    complete    tools    beta    group    implicated    cell    signalling    world    anticancer    biology    data    cancer    francis    inhibitors    ladbury    benefit    pathogenesis    molecular    critical    treating    secondment    simulations    caroline    human    researcher    cancers    microenvironment    dysregulation    prof    innovative    forefront    interplay    avenues    crick    tgf    continue    canonical    disorders    transforming    mechanistic    class    tissue    structural    engineered    bedside    shutdown    cytokines    signaling    biophysical    john    diseases    silico    cellular    manipulate    receptors    understand    initiation    hill    join    laboratory    discovering    pittsburgh    fibrotic    responsible    dr    protein    roles    ukasz    outcomes    university    andrew    excessive    return    isoform    soft    fellow    family    employ    connective    developmental    peptide    significance    special    hinck    therapeutic    btb    progression    wieteska    basic    bench    leeds   

Project "TGF-BTB" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 271˙732 €
 EC max contribution 271˙732 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 271˙732.00
2    UNIVERSITY OF PITTSBURGH US (PITTSBURGH) partner 0.00

Map

 Project objective

TGF-BTB (Transforming Growth Factor – Bench To Bedside) is an ambitious and innovative project, the goal of which is to not only to understand the different roles of the TGF-β isoforms as well as in cell signalling at a molecular level, but also to explore their critical roles implicated in pathogenesis of fibrotic disorders and cancer. The dysregulation or complete shutdown of TGF-β pathway is responsible for many human diseases including connective tissue disorders, fibrotic disorders and the initiation and progression of soft tissue cancers. Most recent data show the importance of TGF-β in controlling the tumor microenvironment and its significance in the course of anticancer immunotherapies. The project will employ methods of structural and cell biology, together with in silico simulations, and will include the development of new tools, such as isoform-specific peptide-based inhibitors, engineered cytokines to study and manipulate the TGF-β canonical and non-canonical pathways. TGF-BTB is not only of great importance for increasing basic mechanistic understanding of TGF-β signalling, but also in terms of discovering potential new therapeutic avenues for treating diseases driven by excessive TGF-b signaling. During the outgoing phase, The Fellow, Dr Łukasz Wieteska, will join Prof Andrew Hinck’s research group at the University of Pittsburgh, which is a world class research laboratory at the forefront of TGF-β family structural studies. the Fellow will return to the University of Leeds to continue his work with Prof John Ladbury, whose research has a strong focus on exploring the structural, biophysical, and cellular outcomes of the interplay of protein receptors in cell signalling pathways. Upon return, the Fellow will also benefit from a secondment at The Francis Crick Institute in the laboratory of Dr Caroline Hill, a leading researcher in the field of developmental biology with a special focus on TGF-β signaling.

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The information about "TGF-BTB" are provided by the European Opendata Portal: CORDIS opendata.

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