PROMYS
Programming synthetic networks for bio-based production of value chemicals
| Coordinatore | DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
| Nazionalità Coordinatore | Denmark [DK] |
| Totale costo | 9˙372˙087 € |
| EC contributo | 7˙188˙402 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2013-7-single-stage |
| Funding Scheme | CP-TP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-12-01 - 2017-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | coordinator | 2˙312˙890.00 |
| 2 |
RIJKSUNIVERSITEIT GRONINGEN
Organization address
address: Broerstraat 5 contact info |
NL (GRONINGEN) | participant | 1˙004˙400.00 |
| 3 |
TECHNISCHE UNIVERSITAET DARMSTADT
Organization address
address: Karolinenplatz 5 contact info |
DE (DARMSTADT) | participant | 904˙418.00 |
| 4 |
BACMINE SL
Organization address
address: CALLE ISAAC NEWTON 2 PARQUE contact info |
ES (TRES CANTOS) | participant | 813˙471.00 |
| 5 |
THE UNIVERSITY OF WARWICK
Organization address
address: Kirby Corner Road - University House - contact info |
UK (COVENTRY) | participant | 722˙423.00 |
| 6 |
BIOSYNTIA APS
Organization address
address: KOGLE ALLE 6 contact info |
DK (HORSHOLM) | participant | 718˙000.00 |
| 7 |
EVOLVA AG
Organization address
address: DUGGINGERSTRASSE 23 contact info |
CH (REINACH) | participant | 712˙800.00 |
Mappa
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Obiettivo del progetto (Objective)
'The global chemical industry is transitioning from petrochemical production processes to bio-based production processes. This transition creates a clear market need for technologies that reduce the development time and cost of cell factories. PROMYS will develop, validate and implement a novel synthetic biology platform technology termed ligand responsive regulation and selection systems. Ligand responsive regulation and selection systems are biological devices that integrate biological sensing modules, within larger regulatory networks to control cellular programs. This technology will drastically accelerate the construction, optimization and performance of cell factories by enabling industrial users to impose non-natural objectives on the engineered cell factory. PROMYS will address three major challenges in metabolic engineering that limit the development of new cell factories: 1) Synthetic pathway construction 2) Cell factory optimization 3) Control of populations during fermentation
Ligand responsive regulation and selection systems will directly couple the presence of a desired chemical product or flux state within a cell, to the survival of the cell. As such, they allow the in vivo identification of the needle (e.g. functional pathway or optimized cell factories) in a haystack (e.g. large libraries). In addition, the technology developed in PROMYS will be applied to deliver increased fermentation yields by continuously selecting for high yielding cell factories within the fermentation population. PROMYS is industry driven and designed such that the expected innovations of each work package have a direct commercialization partner, which is willing to commit the necessary resources to develop commercial products from the innovation.'