PREDICT

Computational prediction of drug cardiac toxicity

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

 Organization address address: University Offices, Wellington Square
city: OXFORD

contact info
Cognome: FLETCHER, KATHERINE
Email: send email
Telefono: -669
Fax: -669

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 5˙545˙692 €
 EC contributo 4˙100˙000 €
 Programma FP7-ICT
Specific Programme "Cooperation": Information and communication technologies
 Funding Scheme CP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-06-01   -   2011-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD

contact info
Cognome: FLETCHER, KATHERINE
Email: send email
Telefono: -669
Fax: -669

UK (OXFORD) coordinator 0.00
2    AUREUS PHARMA SA

 Organization address address: QUAI DE JEMMAPES 174
city: PARIS 10
postcode: 75010

contact info
Cognome: N/A

FR (PARIS 10) participant 0.00
3    CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA

 Organization address address: Via Palabanda 9
city: CAGLIARI

contact info
Cognome: N/A

IT (CAGLIARI) participant 0.00
4    F. HOFFMANN-LA ROCHE AG

 Organization address address: GRENZACHERSTRASSE 124
city: BASEL

contact info
Cognome: N/A

CH (BASEL) participant 0.00
5    FUJITSU LABORATORIES OF EUROPE LIMITED

 Organization address address: HAYES PARK CENTRAL, HAYES END ROAD
city: HAYES, MIDDLESEX
postcode: UB4 8FE

contact info
Cognome: N/A

UK (HAYES, MIDDLESEX) participant 0.00
6    GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.

 Organization address address: Great West Road 980
city: BRENTFORD

contact info
Cognome: N/A

UK (BRENTFORD) participant 0.00
7    NOVARTIS PHARMA AG

 Organization address address: LICHTSTRASSE 35
city: BASEL

contact info
Cognome: N/A

CH (BASEL) participant 0.00
8    SZEGEDI TUDOMANYEGYETEM

 Organization address address: DUGONICS TER 13
city: SZEGED
postcode: 674

contact info
Cognome: N/A

HU (SZEGED) participant 0.00
9    UNIVERSIDAD POLITECNICA DE VALENCIA

 Organization address address: Camino de Vera s/n
city: VALENCIA

contact info
Cognome: N/A

ES (VALENCIA) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

simulations    interactions    computations    ict    actions    human    time    spatial    heart    drugs    drug    electrophysiology    vph    models    computational    tools   

 Obiettivo del progetto (Objective)

Many drugs fail to reach the market because of side effects on the heart. The principal objective of this proposal is to create an advanced computational technology for in silico assessment of the efficacy and safety of specific drugs [ICT-2007.5.3(c) (3)], i.e. an open environment comprising validated computational models, tools and numerical methods that will enable simulations of drug actions on the electrophysiology of the human heart.

Such simulations will involve modelling of drug interactions at the molecular and cellular level, will extend current technology to enable prediction of the effects of those interactions on the dynamics of the whole heart, and will lead to an understanding of how genetic factors can be used to assess patient-specific risk profiles. This requires a multi-level systems approach, based on multi-scale, multi-physics methods, including computations on adaptive spatial grids and multi-grid time integration. Computations on realistic models at appropriate spatial and temporal scales are currently not feasible, so we will investigate new algorithms and their implementation on high-performance platforms, including a new generation of petaflop computers, to achieve 'faster than real-time' simulation.

These tools form part of the infrastructure required to simulate the physiology of major organ systems, thereby contributing to the goal of creating the Virtual Physiological Human (VPH) [ICT-2007.5.3]. The balanced team in this project, including founders of the Human Physiome Project, has decades of experience in the experimental study and modelling of the electrophysiology and mechanics of the heart, while pharmaceutical industry partners bring deep understanding of the mechanisms of drug actions. The results will demonstrate the value of the VPH initiative to fundamental scientific understanding of the heart, with major economic and clinical impacts through accelerated drug development, approval and use.

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