DIAPREPP

"DIAbetes type 1 PRediction, Early Pathogenesis and Prevention"

 Coordinatore TECHNISCHE UNIVERSITAET DRESDEN 

 Organization address address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069

contact info
Titolo: Mr.
Nome: Sven
Cognome: Kreigenfeld
Email: send email
Telefono: +49 351 46339744
Fax: +49 351 46339742

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.diaprepp.eu/
 Totale costo 7˙794˙397 €
 EC contributo 5˙999˙200 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2011-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET DRESDEN

 Organization address address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069

contact info
Titolo: Mr.
Nome: Sven
Cognome: Kreigenfeld
Email: send email
Telefono: +49 351 46339744
Fax: +49 351 46339742

DE (DRESDEN) coordinator 0.00
2    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

 Organization address address: Via Olgettina 60
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 26434845
Fax: +39 02 26433781

IT (MILANO) participant 0.00
3    FORSCHERGRUPPE DIABETES E. V. - INSTITUT FUER DIABETESFORSCHUNG

 Organization address address: INGOLSTADTER LANDSTRASSE 1
city: OBERSCHLEISSHEIM NEUHERBERG
postcode: 85764

contact info
Titolo: Prof.
Nome: Anette-G.
Cognome: Ziegler
Email: send email
Telefono: +49 89 31873173
Fax: +49 89 3081733

DE (OBERSCHLEISSHEIM NEUHERBERG) participant 0.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Annick
Cognome: Bertault
Email: send email
Telefono: +33 1 40784901
Fax: +33 1 40784997

FR (PARIS) participant 0.00
5    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Dr.
Nome: Andreas
Cognome: Andersson
Email: send email
Telefono: +46 40 391050
Fax: +46 40391065

SE (LUND) participant 0.00
6    RSR LIMITED

 Organization address address: "Avenue Park, Pantwyn"
city: CARDIFF
postcode: CF23 8HE

contact info
Titolo: Dr.
Nome: Bernard
Cognome: Rees Smith
Email: send email
Telefono: +4429 2073 2076
Fax: +4429 2073 2704

UK (CARDIFF) participant 0.00
7    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Ms.
Nome: Katri
Cognome: Kokkila
Email: send email
Telefono: +358 20 7223303
Fax: +358 20 7223365

FI (ESPOO) participant 0.00
8    TERVEYDEN JA HYVINVOINNIN LAITOS

 Organization address address: MANNERHEIMINTIE 166
city: HELSINKI
postcode: 300

contact info
Titolo: Mr.
Nome: Jaakko
Cognome: Penttinen
Email: send email
Telefono: +358 9 4744 8203
Fax: +358 9 4744 8225

FI (HELSINKI) participant 0.00
9    UNIVERSITAT DE BARCELONA

 Organization address address: GRAN VIA DE LES CORTS CATALANES 585
city: BARCELONA
postcode: 8007

contact info
Titolo: Prof.
Nome: Marta
Cognome: Cascante
Email: send email
Telefono: +34 934021217
Fax: +34 934021219

ES (BARCELONA) participant 0.00
10    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Prof.
Nome: Olle
Cognome: Korsgren
Email: send email
Telefono: +46 18 6114187
Fax: +46 18 6110222

SE (UPPSALA) participant 0.00
11    VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA

 Organization address address: KIINAMYLLYNKATU 4-8
city: TURKU
postcode: 20520

contact info
Titolo: Mr.
Nome: Risto
Cognome: Laalo
Email: send email
Telefono: +358 2 3131100
Fax: +358 2 3133120

FI (TURKU) participant 0.00
12    ZORA BIOSCIENCES LTD

 Organization address address: Biologinkuja 1
city: ESPOO
postcode: 2150

contact info
Titolo: Dr.
Nome: Reini
Cognome: Hurme
Email: send email
Telefono: +358 407560766
Fax: 358207000000

FI (ESPOO) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

events    markers    autoimmune    cohort    diaprepp    samples       progression    autoimmunity    islet    pathogenesis    disease    antigens    cells    immunization    auto    pre    diabetes    beta    cell   

 Obiettivo del progetto (Objective)

'The earliest currently identifiable process in the pathogenesis of type 1 diabetes (T1D) is the development of autoimmunity to islet beta cells in the form of autoantibodies. Hindering attempts to prevent autoimmune T1D, the aetiology and pathogenesis of the islet auto-immunization, including whether it is preceded by metabolic abnormalities and cell-mediated autoimmunity, is still poorly understood. To overcome this, DIAPREPP will focus on the early auto-immunization against islet antigens, in particular to disclose events preceding current autoantibody markers. The concept is that events prior to auto-immunization govern the likelihood and ‘signature’ of immunization, which in turn determines progression to disease. The overall objective is to determine mechanisms of islet autoantigen immunization. In a truly collaborative manner, and through five S/T workpackages plus three dedicated to dissemination, training, and management, DIAPREPP will 1. provide a unique set of clinical material that includes a case-control cohort representative of the world’s largest studies of pre-T1D, with follow-up and samples from birth, and pancreatic islets and lymph nodes from patients; 2. investigate the effects of environmental exposure to infections on islet cells and immune cells; 3. perform extensive metabolomic analysis of pre-autoimmune samples and in relevant animal models to test mechanistic hypotheses of auto-immunization; 4. carry out detailed analyses of early autoimmune responses with a special focus on autoreactive CD8 T cells; and 5. apply findings to ongoing prevention studies. The expected impact of DIAPREPP is new fundamental knowledge regarding how 1. immunization against islet autoantigens can occur; 2. signs of self-immunization can be exploited for prediction and monitoring of disease; and 3. the immunization or its progression to islet beta cell destruction and T1D development can be prevented.'

Introduzione (Teaser)

Understanding the causes of type1 diabetes (T1D) and finding early disease markers seem the only way forward to reduce disease incidence. Based on this, the DIAPREPP consortium set out to identify and exploit early events in the development of autoimmunity against islet beta antigens in a large cohort of children.

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