NGIN

Next Generation HIV-1 Immunogens inducing broadly reactive Neutralising antibodies

 Coordinatore UNIVERSITA VITA-SALUTE SAN RAFFAELE 

 Organization address address: Via Olgettina 58
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845
Fax: +39 02 26434717

 Nazionalità Coordinatore Italy [IT]
 Totale costo 10˙148˙011 €
 EC contributo 7˙534˙742 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-02-01   -   2012-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA VITA-SALUTE SAN RAFFAELE

 Organization address address: Via Olgettina 58
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845
Fax: +39 02 26434717

IT (MILANO) coordinator 0.00
2    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Mr.
Nome: Erik
Cognome: Veenstra
Email: send email
Telefono: +31 20 5667681
Fax: +31 20 6915462

NL (AMSTERDAM) participant 0.00
3    AVARIS AB

 Organization address address: "C/O Karolisnka Innovations AB, Fogdevreten 2B"
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Jonny
Cognome: Greinsmark
Email: send email
Telefono: +46 8 524 869 99
Fax: +46 8 30 34 23

SE (STOCKHOLM) participant 0.00
4    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Dr.
Nome: Nathalie
Cognome: Le-Gouzouguec
Email: send email
Telefono: +33 1 4654 9789
Fax: +33 1 4654 9180

FR (PARIS 15) participant 0.00
5    CYTOS BIOTECHLOLOGY AG

 Organization address address: "Waggistrasse, 25"
city: ZURICH-SCHLIEREN
postcode: 8952

contact info
Titolo: Dr.
Nome: Philippe
Cognome: Saudan
Email: send email
Telefono: +41 44 7334642
Fax: +41 44 7334659

CH (ZURICH-SCHLIEREN) participant 0.00
6    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

 Organization address address: Via Olgettina 60
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845
Fax: +39 02 2643 3781

IT (MILANO) participant 0.00
7    HEALTH PROTECTION AGENCY HPA

 Organization address address: Central Office - 7th Floor, Holborn Gate - High Holborn 330
city: LONDON
postcode: WC1V 7PP

contact info
Titolo: Ms.
Nome: Deborah
Cognome: Smith
Email: send email
Telefono: +44 1 707 641482
Fax: +44 1 707 641051

UK (LONDON) participant 0.00
8    ISTITUTO NAZIONALE TUMORI Fondazione Pascale

 Organization address address: Via Mariano Semmola 142
city: NAPOLI
postcode: 80131

contact info
Titolo: Dr.
Nome: Vincenza
Cognome: Farinari
Email: send email
Telefono: +39 081 590 3294
Fax: +39 081 590 3827

IT (NAPOLI) participant 0.00
9    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Ms.
Nome: Hedde
Cognome: Lundgren
Email: send email
Telefono: +46 8 524 86 334
Fax: +46 8 330744

SE (STOCKHOLM) participant 0.00
10    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Ms.
Nome: Anette
Cognome: Welin
Email: send email
Telefono: +46 46 2220729
Fax: +46 46 184493

SE (LUND) participant 0.00
11    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: Atul
Cognome: Kotecha
Email: send email
Telefono: 44-(0)1235841035
Fax: +44-(0)1235841222

UK (SWINDON) participant 0.00
12    MYMETICS SA

 Organization address address: ROUTE DE LA CORNICHE 4
city: EPALINGES
postcode: 1066

contact info
Titolo: Ms.
Nome: Carmelina
Cognome: Mahrer
Email: send email
Telefono: +41 21 653 48 85
Fax: +41 21 653 24 73

CH (EPALINGES) participant 0.00
13    Ospedale San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845
Fax: +39 02 2643 4717

IT (Milano) participant 0.00
14    PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE

 Organization address address: Nationalestraat 155
city: ANTWERPEN
postcode: 2000

contact info
Titolo: Ms.
Nome: Nancy
Cognome: Janssens
Email: send email
Telefono: +32 32 476473
Fax: +32 32 476223

BE (ANTWERPEN) participant 0.00
15    STATENS SERUM INSTITUT

 Organization address address: ARTILLERIVEJ 5
city: KOBENHAVN S
postcode: 2300

contact info
Titolo: Dr.
Nome: Vibeke Lund
Cognome: Fonsholt
Email: send email
Telefono: +45 32 683129
Fax: +45 32 683008

DK (KOBENHAVN S) participant 0.00
16    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Dr.
Nome: Stephen
Cognome: Conway
Email: send email
Telefono: +44 186 528 9811
Fax: +44 186 528 9801

UK (OXFORD) participant 0.00
17    UNIVERSITA DEGLI STUDI DI MILANO

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Dr.
Nome: Alessandro
Cognome: Cavallina
Email: send email
Telefono: +39 02 5033 0413
Fax: +39 02 5033 0414

IT (MILANO) participant 0.00
18    UNIVERSITE PARIS DESCARTES

 Organization address address: Rue de l'Ecole de Medecine 12
city: PARIS
postcode: 75270

contact info
Titolo: Mr.
Nome: Stephan
Cognome: Sirven
Email: send email
Telefono: +33 01 40461714
Fax: +33 01 40461615

FR (PARIS) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

envelope    primates    formulations    nabs    broadly    human    antigenicity    immunogens    eliciting    generation    virus    envelopes    nab    vaccine    proteins    expressed    antibodies    adjuvant    hiv    immunogenicity    trimeric    broad    neutralising    rabbits    successfully   

 Obiettivo del progetto (Objective)

'The elicitation of broadly neutralising antibodies (Nab) remains the primary and most challenging goal in HIV-1 vaccine development. Although a few anti-HIV-1 monoclonal antibodies with broadly neutralising capability have been isolated from infected individuals, none of the immunization strategies thus far explored has proven effective in inducing similar antibodies. Objective of this application is the development of a variety of ‘next-generation’ HIV-1 envelope-based immunogens that in combination with new adjuvant formulations are capable of eliciting high-titer broadly Nab responses. Our strategy will be based on one side on the identification and cloning of envelopes that have successfully elicited broad Nabs in their natural hosts, focusing on HIV-1 strains derived from patients with high-titered broad Nabs in their sera; on the other side, we will introduce rational modifications into these and promising HIV-env based immunogens that are already under development by NGIN’s partners, with the aim of exposing cryptic conserved neutralization epitopes and permitting their efficient presentation to the immune system. HIV-1 envelopes will be expressed in viral vectors or as trimeric (gp150) soluble proteins and screened for their immunogenicity and antigenicity in rabbits. A selection of envelopes with highest antigenicity will be expressed as trimeric envelope-complexes on the surface of virosomes or virus-like particles (VLP), to further improve immunogenicity. New immunogens will be evaluated in prime-boost regimens in rabbits using novel effective adjuvant formulations. Immunogen/adjuvant combinations that prove most effective in eliciting broadly Nabs both systemically and at the mucosal level will be evaluated in non-human primates for their immunogenicity and efficacy upon challenge with live heterologous virus. Finally, formulations that will elicit protective immunity in non-human primates will be forwarded for proof-of-principle testing in humans.'

Introduzione (Teaser)

A large European consortium is addressing the challenging issue of HIV vaccine development. Using novel HIV-1 envelope proteins as candidate antigens, they successfully demonstrated the generation of neutralising antibodies in rabbits and non-human primates.

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