REBORNE

Regenerating Bone defects using New biomedical Engineering approaches

 Coordinatore INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) 

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Marianne
Cognome: Desmedt
Email: send email
Telefono: +33 2 40 35 06 69
Fax: +33 2 40 17 77 01

 Nazionalità Coordinatore France [FR]
 Totale costo 15˙472˙075 €
 EC contributo 11˙935˙340 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-single-stage
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-01-01   -   2015-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Marianne
Cognome: Desmedt
Email: send email
Telefono: +33 2 40 35 06 69
Fax: +33 2 40 17 77 01

FR (PARIS) coordinator 2˙121˙051.00
2    ETABLISSEMENT FRANCAIS DU SANG

 Organization address address: AVENUE DU STADE DE FRANCE 20
city: LA PLAINE SAINT DENIS CEDEX
postcode: 93218

contact info
Titolo: Mr.
Nome: Laurent
Cognome: Beauverger
Email: send email
Telefono: +33 2 47 36 21 60
Fax: +33 2 47362187

FR (LA PLAINE SAINT DENIS CEDEX) participant 1˙439˙351.40
3    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: +49 731 500 66397
Fax: +49 731 500 66392

DE (ULM) participant 1˙356˙006.40
4    UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

 Organization address address: VIA UNIVERSITA 4
city: MODENA
postcode: 41100

contact info
Titolo: Prof.
Nome: Guiseppe
Cognome: Torelli
Email: send email
Telefono: 39594224462
Fax: 39594223341

IT (MODENA) participant 803˙109.25
5    UNIVERSIDAD AUTONOMA DE MADRID

 Organization address address: CALLE EINSTEIN, CIUDAD UNIV CANTOBLANCO RECTORADO 3
city: MADRID
postcode: 28049

contact info
Titolo: Ms.
Nome: Ana
Cognome: Amigo
Email: send email
Telefono: +34 914972897
Fax: +34 914972978

ES (MADRID) participant 630˙499.50
6    FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO

 Organization address address: VIA FRANCESCO SFORZA 28
city: MILANO
postcode: 20122

contact info
Titolo: Dr.
Nome: Rosaria
Cognome: Giordano
Email: send email
Telefono: +39 255034053
Fax: +39 25458129

IT (MILANO) participant 546˙715.56
7    UNIVERSITA DEGLI STUDI DI VERONA

 Organization address address: VIA DELL ARTIGLIERE 8
city: VERONA
postcode: 37129

contact info
Titolo: Dr.
Nome: Giovanni
Cognome: Menegatti
Email: send email
Telefono: 390458000000
Fax: 390458000000

IT (VERONA) participant 481˙199.62
8    BIOMATLANTE SAS

 Organization address address: rue Edouard Belin - ZA des IV Nations 5
city: VIGNEUX DE BRETAGNE
postcode: 44360

contact info
Titolo: Ms.
Nome: Isabelle
Cognome: Bocherel
Email: send email
Telefono: +33 2 28020009
Fax: +33 2 28020010

FR (VIGNEUX DE BRETAGNE) participant 477˙500.00
9    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Dr.
Nome: Ingo
Cognome: Müller
Email: send email
Telefono: 4970710000000
Fax: 497071000000

DE (TUEBINGEN) participant 465˙696.00
10    UNIVERSITETET I BERGEN

 Organization address address: Museplassen 1
city: BERGEN
postcode: 5007

contact info
Titolo: Ms.
Nome: Inger
Cognome: Gjesdahl
Email: send email
Telefono: 4755584980
Fax: 4755584991

NO (BERGEN) participant 409˙868.75
11    XPAND BIOTECHNOLOGY BV

 Organization address address: PROFESSOR BRONKHORSTLAAN 10D
city: BILTHOVEN
postcode: 3723 MB

contact info
Titolo: Dr.
Nome: Florence
Cognome: De Groot
Email: send email
Telefono: +31 30 229 7294
Fax: +31 30 227299

NL (BILTHOVEN) participant 401˙600.00
12    ALCIMED

 Organization address address: BOULEVARD DE MONTMORENCY 57
city: PARIS
postcode: 75016

contact info
Titolo: Mr.
Nome: David
Cognome: Bariau
Email: send email
Telefono: 33144304438
Fax: 33144304432

FR (PARIS) participant 374˙964.00
13    ISTITUTO ORTOPEDICO RIZZOLI

 Organization address address: VIA DI BARBIANO 1/10
city: BOLOGNA
postcode: 40136

contact info
Titolo: Dr.
Nome: Andrea
Cognome: Rizzi
Email: send email
Telefono: 390516000000
Fax: 390516000000

IT (BOLOGNA) participant 363˙180.00
14    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Udo
Cognome: Schreiner
Email: send email
Telefono: 496131000000
Fax: 496131000000

DE (MUENCHEN) participant 352˙448.88
15    UNIVERSITAT POLITECNICA DE CATALUNYA

 Organization address address: Jordi Girona 31
city: BARCELONA
postcode: 8034

contact info
Titolo: Prof.
Nome: Maria Pau
Cognome: Ginebra
Email: send email
Telefono: +34 934017706
Fax: +34 934016706

ES (BARCELONA) participant 304˙855.00
16    KITOZYME SA

 Organization address address: RUE HAUTE CLAIRE PARC INDUSTRIEL 4
city: HERSTAL
postcode: 4040

contact info
Titolo: Mr.
Nome: Arnaud
Cognome: Hamers
Email: send email
Telefono: +32 4 2598500
Fax: +32 4 2598509

BE (HERSTAL) participant 300˙160.00
17    UNIVERSITATEA DE MEDICINA SI FARMACE VICTOR BABES TIMISOARA

 Organization address address: PIATA EFTIMIE MURGU 2A
city: TIMISOARA
postcode: 300041

contact info
Nome: Constanta
Cognome: Caplar
Email: send email
Telefono: 40256201290
Fax: 40256220479

RO (TIMISOARA) participant 247˙600.00
18    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Dr.
Nome: Nathalie
Cognome: Rouas-Freiss
Email: send email
Telefono: +33 1 57276801
Fax: +33 1 48031960

FR (PARIS 15) participant 224˙994.00
19    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Dr.
Nome: P.J.A.
Cognome: De Koning
Email: send email
Telefono: 31887559883
Fax: 31887555504

NL (UTRECHT) participant 199˙940.00
20    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Mr.
Nome: Christophe
Cognome: Misse
Email: send email
Telefono: +33 1 44841770
Fax: +33 1 44841788

FR (PARIS) participant 121˙388.00
21    HOPITAL UNIVERSTAIRE DE TOURS

 Organization address city: TOURS CEDEX 1
postcode: 37044

contact info
Titolo: Prof.
Nome: Philippe
Cognome: Rosset
Email: send email
Telefono: +33 247475915
Fax: +33 2 47475912

FR (TOURS CEDEX 1) participant 112˙050.00
22    CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

 Organization address address: Allee de l'Ile Gloriette 5
city: NANTES
postcode: 44093

contact info
Titolo: Ms.
Nome: Annes
Cognome: Brethet
Email: send email
Telefono: +33 2 53 48 28 25
Fax: +33 2 53 48 28 26

FR (NANTES) participant 99˙892.17
23    AZIENDA OSPEDALIERO-UNIVERSITARIA ANNA MEYER

 Organization address address: VIALE PIERACCINI 24
city: FIRENZE
postcode: 50139

contact info
Titolo: Dr.
Nome: Franco
Cognome: Bambi
Email: send email
Telefono: +39 055 5662991

IT (FIRENZE) participant 88˙800.00
24    UNIVERSITE DE LIEGE

 Organization address city: LIEGE
postcode: 4000

contact info
Titolo: Prof.
Nome: Eric
Cognome: Rompen
Email: send email
Telefono: +32 4 366 82 90
Fax: +32 4 366 82 90

BE (LIEGE) participant 12˙470.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

tissue    allogenic    orthopaedic    trials    cells    reborne    children    sources    autologous    patients    clinical    biomaterials    surgery    mesenchymal    maxillofacial    grafts    bone    stem   

 Obiettivo del progetto (Objective)

'Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autografts account for more than 80% of total graft volume. Significant growth opportunities exist for synthetic bone grafts in association with mesenchymal stem cells from autologous or allogenic sources as alternatives to biological bone grafts in orthopaedic and maxillofacial surgery. The objectives of REBORNE is to perform clinical trials using advanced biomaterials and cells triggering bone healing in patients. In order to reach this goal, five phase II clinical studies with 20 patients are proposed in 12 clinical centres spread in 8 European countries. Three orthopaedic trials concerning the treatment of long bone fractures and osteonecrosis of the femoral head in adults or children will be conducted using bioceramics, hydrogel for percuteneous injection and stem cells from autologous or allogenic sources. Clinical research will also concern maxillofacial surgery with bone augmentation prior to dental implants and the reconstruction of cleft palates in children. The safety and efficacy of the new therapies will be assessed clinically using X-rays, CT scans and MRI as well as histology of biopsies. These ambitious clinical targets will require research and development efforts from a large consortium of top world class laboratories, SMEs manufacturing biomaterials, GMP-cell producing facilities and surgeons in hospitals as well as the consideration of ethical and regulatory issues. It is expected that REBORNE will expand the competitiveness of Europe through the patenting of new CE-marked bioproducts in the field of regenerative medicine.'

Introduzione (Teaser)

Bone tissue engineering is a novel approach that has received much attention lately as a promising alternative to autologous bone transplantation. An EU-funded study proposed the utilisation of mesenchymal stem cells (MSCs) for bone regeneration.

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