PORRSCON

New tools and approaches to control Porcine Reproductive and Respiratory Syndrome (PRRS) in the EU and Asia

 Coordinatore UNIVERSITEIT GENT 

 Organization address address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000

contact info
Titolo: Ms.
Nome: Saskia
Cognome: Vanden Broeck
Email: send email
Telefono: +32 9 264 31 24
Fax: +32 9 264 35 83

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 4˙092˙316 €
 EC contributo 2˙999˙070 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2009-3
 Funding Scheme CP-FP-SICA
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-01-01   -   2014-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT

 Organization address address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000

contact info
Titolo: Ms.
Nome: Saskia
Cognome: Vanden Broeck
Email: send email
Telefono: +32 9 264 31 24
Fax: +32 9 264 35 83

BE (GENT) coordinator 461˙100.00
2    EIDGENOESSISCHES DEPARTEMENT DES INNERN

 Organization address address: Inselgasse 1
city: BERN
postcode: 3003

contact info
Nome: Caroline
Cognome: De St. Simon
Email: send email
Telefono: +41 31 848 92 11
Fax: +41 31 848 92 22

CH (BERN) participant 260˙014.00
3    STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

 Organization address address: Costerweg 50
city: WAGENINGEN
postcode: 6701BH

contact info
Titolo: Dr.
Nome: Annemarie
Cognome: Rebel
Email: send email
Telefono: +31 320238108
Fax: +31 320 238153

NL (WAGENINGEN) participant 259˙990.00
4    THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS

 Organization address address: Area 1A, Nobel House, Smith Square 17
city: LONDON
postcode: SW1P 3JR

contact info
Titolo: Ms.
Nome: Lucinda
Cognome: Cranham
Email: send email
Telefono: +44 1932 359571
Fax: +44 1932 357230

UK (LONDON) participant 259˙859.00
5    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Mr.
Nome: Carlos Manuel
Cognome: Abad Ruiz
Email: send email
Telefono: +34 91 566 88 52
Fax: +34 91 566 89 13

ES (MADRID) participant 259˙700.00
6    DANMARKS TEKNISKE UNIVERSITET

 Organization address address: Anker Engelundsvej 1, Building 101A
city: KONGENS LYNGBY
postcode: 2800

contact info
Titolo: Dr.
Nome: Lars Erik
Cognome: Lars
Email: send email
Telefono: 4535866274
Fax: 4535866340

DK (KONGENS LYNGBY) participant 259˙600.00
7    INMUNOLOGIA Y GENETICA APLICADA SA

 Organization address address: Hermanos Garcia Noblejas 41
city: MADRID
postcode: 28037

contact info
Titolo: Ms.
Nome: Rodriguez
Cognome: Maria Jose
Email: send email
Telefono: +34 91 3680501
Fax: +34 91 4087598

ES (MADRID) participant 200˙070.00
8    PANSTWOWY INSTYTUT WETERYNARYJNY - PANSTWOWY INSTYTUT BADAWCZY

 Organization address address: Partyzantow 57
city: PULAWY
postcode: 24100

contact info
Titolo: Dr.
Nome: Tomasz
Cognome: Stadejek
Email: send email
Telefono: +48 81 889 3099
Fax: +48 81 886 25 95

PL (PULAWY) participant 199˙999.00
9    FUNDACIO CENTRE DE RECERCA EN SANITAT ANIMAL CRESA

 Organization address address: UNIVERSIDAD AUTONOMA DE BARCELONA EDIFICI CReSA
city: BARCELONA
postcode: 8193

contact info
Titolo: Ms.
Nome: Silvia
Cognome: Pratsavall
Email: send email
Telefono: +34 93 581 44 91
Fax: +34 93 581 44 90

ES (BARCELONA) participant 199˙728.00
10    PARCO TECNOLOGICO PADANO S.R.L.

 Organization address address: Via Einstein - Localita Cascina Codazza
city: LODI
postcode: 26900

contact info
Titolo: Dr.
Nome: Gianluca
Cognome: Carenzo
Email: send email
Telefono: +39 0371 4662215
Fax: +39 0371 4662217

IT (LODI) participant 159˙980.00
11    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: 441317000000
Fax: 441317000000

UK (EDINBURGH) participant 159˙905.00
12    Shanghai Veterinary Research Institute - Chinese Academy of Agricultural Sciences

 Organization address address: ZIYUE ROAD 518
city: SHANGHAI
postcode: 200241

contact info
Titolo: Dr.
Nome: Shishan
Cognome: Yuan
Email: send email
Telefono: +86 21 3429 3137
Fax: +86 21 5408 1818

CN (SHANGHAI) participant 128˙200.00
13    MINISTRY OF AGRICULTURE AND RURAL DEVELOPMENT

 Organization address address: "Lane 78, Giai Phong 15"
city: Hanoi
postcode: 844

contact info
Titolo: Dr.
Nome: Van Long
Cognome: Nguyen
Email: send email
Telefono: +84 936053837
Fax: +84 48686339

VN (Hanoi) participant 97˙725.00
14    China Agricultural University

 Organization address address: yuanmingyuan Xilu 2
city: Beijing

contact info
Titolo: Ms.
Nome: Ruying
Cognome: Gao
Email: send email
Telefono: 861063000000
Fax: 861063000000

CN (Beijing) participant 80˙000.00
15    Boehringer Ingelheim Vetmedica

 Organization address address: Binger Str 173
city: Ingelheim
postcode: 55216

contact info
Titolo: Dr.
Nome: Vicky
Cognome: Fachinger
Email: send email
Telefono: +49 6132 77 8353
Fax: +49 6132 77 2947

DE (Ingelheim) participant 13˙200.00
16    EIDGENOESSISCHES DEPARTEMENT FUER WIRTSCHAFT, BILDUNG UND FORSCHUNG

 Organization address address: Bundeshaus Ost
city: BERN
postcode: 3003

contact info
Titolo: Ms.
Nome: Caroline
Cognome: De St. Simon
Email: send email
Telefono: +41 31 848 9211
Fax: +41 31 848 9222

CH (BERN) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

immune    respiratory    prrsv    infections    assays    genetic    antibiotics    kits    syndrome    marker    isolates    public    diva    reproductive    porcine    found    pathogenic    proteins    strains    health    animal    immunity    spread    subtypes    tools    vaccines    pathogenesis    asia    virulence    vaccine    variants    porrscon    pigs    resistance    addition    virus    genotypes    extensive    modulation    pig    worldwide    prrs    losses    infection    piglets   

 Obiettivo del progetto (Objective)

'Porcine reproductive and respiratory syndrome virus (PRRSV) is the major cause of reproductive and respiratory problems in pigs worldwide. Controlling this disease is a top priority in pig producing countries. Due to mutations at a high frequency, new variants of the virus appear that are no longer effectively controlled by the commercial vaccines. In addition, highly virulent variants emerge, leading to high losses. With regard to animal welfare and agricultural economics, there is an urgent need to control PRRS. Furthermore, the abusive use of antibiotics to control PRRSV-associated respiratory problems may lead to resistance that may endanger public health. PoRRSCon is an initiative of 14 partners originating from Europe and Asia with strong expertises in virology and immunology. They are doing frontline research on PRRSV and/or vaccine development. Two of these partners are leading European pharmaceutical companies that will guide the consortium in the direction of exploitable results. By joining their strengths they have an ideal position to be successful in one of the most difficult challenges in pig health, controlling PRRS. To reach this final goal, the following objectives are forwarded:(i) characterize genetically and antigenically current PRRSV isolates in Europe and Asia, (ii) have a better understanding of the complex pathogenesis of PRRSV infections, immune response against PRRSV and immune modulation by PRRSV, (iii) define the genetic base of PRRSV virulence, (iv) identify PRRSV proteins and domains on these viral proteins that are involved in the induction of the immunity against PRRSV and in the immune modulation of PRRSV, (v) develop new generation, efficacious and safe marker vaccines that can be adapted to temporary changes and geographical differences and (vi) develop DIVA assays that allow to differentiate infected from vaccinated animals. At the end, it will be possible to set up a control strategy by combining marker vaccines with DIVA assays'

Introduzione (Teaser)

Porcine reproductive and respiratory syndrome virus (PRRSV) constitutes one of the most prevalent infectious diseases in pigs worldwide. Controlling the spread of the virus is crucial to reduce the incurred economic losses.

Descrizione progetto (Article)

PRRSV has considerable genetic variability with emergence of highly pathogenic strains causing extensive pig mortality. It causes reproductive and respiratory problems in pigs and is also undermining the pig's immunity, leading to extensive bacterial infections. Existing vaccines are unable to control all PRRSV strains and widespread use of antibiotics only exacerbates drug resistance incidence.

Seeking to address these issues, the EU funded http://www.porrscon.ugent.be/ (PORRSCON) (New tools and approaches to control porcine reproductive and respiratory syndrome (PRRS) in the EU and Asia), a collaboration between Europe and Asia set out to develop new tools and approaches to control PRRS. In this context they created a public virus bank that included European, Asian and American isolates encompassing both virus genotypes.

Partners sequenced and characterised a number of PRRSV strains with different genotypes and subtypes. For diagnosis, the majority of available PRRSV kits were validated using particular virus subtypes most common in Europe. However, these kits may not be as sensitive for detecting other virus subtypes, emphasising the need for continuously monitoring PRRSV genetic diversity and evaluating diagnostic tests. Ultimately, results revealed that a combination of techniques including serological analysis could prove to be more effective for PRRSV detection.

A currently available vaccine generated against subtype 1 was found to offer partial protection against the highly pathogenic PRRSV subtypes of Eastern Europe. Significant effort was devoted to the development of new vaccines capable of boosting PRRSV-specific humoral immunity and reducing virus load in piglets.

To further facilitate the design of novel vaccines, scientists performed virulence analysis and identified two implicated genes, which could be targeted to attenuate the virus. In addition, they investigated the pathogenesis of congenital infection and measures that could prevent infection of foetuses. To this end, they found one attenuated vaccine capable of protecting piglets against lethal challenge.

Overall, the activities of the PORRSCON project have alerted authorities about PRRSV transmission through international animal trade. The generated tools and vaccines are anticipated to control virus spread and minimise its detrimental consequences.

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