LUPAS

Luminescent polymers for in vivo imaging of amyloid signatures

Coordinatore	LINKOPINGS UNIVERSITET    more  Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 contact info Titolo: Dr. Nome: Magnus Cognome: Fredriksson Email: send email Telefono: +46 13 288972 Fax: +46 13 282550
Nazionalità Coordinatore	Sweden [SE]
Sito del progetto	http://www.lupas-amyloid.eu/
Totale costo	6˙475˙643 €
EC contributo	4˙978˙094 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-11-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	LINKOPINGS UNIVERSITET  Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 contact info Titolo: Dr. Nome: Magnus Cognome: Fredriksson Email: send email Telefono: +46 13 288972 Fax: +46 13 282550	SE (LINKOPING)	coordinator	1˙294˙852.80
2	EBERHARD KARLS UNIVERSITAET TUEBINGEN  Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Prof. Nome: Mathias Cognome: Jucker Email: send email Telefono: +49 7071 29 86863 Fax: +49 7071 29 4521	DE (TUEBINGEN)	participant	663˙372.00
3	NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU  Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 contact info Titolo: Prof. Nome: Mikael Cognome: Lindgren Email: send email Telefono: +47 73593414 Fax: +47 73597710	NO (TRONDHEIM)	participant	654˙249.00
4	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Prof. Nome: Adriano Cognome: Aguzzi Email: send email Telefono: +41 44 255 34 28 Fax: +41 255 44 02	CH (ZURICH)	participant	558˙867.00
5	UNIVERSITE LYON 1 CLAUDE BERNARD  Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 contact info Titolo: Dr. Nome: Javier Cognome: Olaiz Email: send email Telefono: +33 4 72 69 76 00 Fax: +33 4 72 69 76 09	FR (VILLEURBANNE CEDEX)	participant	532˙400.00
6	APPLIED SPECTRAL IMAGING LTD  Organization address address: Hamatechet 4 city: MIGDAL HAEMEK postcode: 10551 contact info Titolo: Dr. Nome: Alaluf Cognome: Orit Email: send email Telefono: +972 4 6547567 Fax: +972 4 6547507	IL (MIGDAL HAEMEK)	participant	512˙448.40
7	CHARITE - UNIVERSITAETSMEDIZIN BERLIN  Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 contact info Titolo: Ms. Nome: Eveline Cognome: Fräßdorf Email: send email Telefono: +49 30 450576024 Fax: +49 30 450576954	DE (BERLIN)	participant	506˙144.00
8	GENOVIS AB  Organization address address: Scheelvaegen 22 city: Lund postcode: 22007 contact info Titolo: Dr. Nome: Sarah Cognome: Fredriksson Email: send email Telefono: +46 702806869 Fax: 4646128020	SE (Lund)	participant	255˙761.60

Mappa

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 Obiettivo del progetto (Objective)

'In this project we seek to develop new smart imaging molecular tools for combating neurodegenerative diseases such as Alzheimer’s disease and prion diseases. Emphasis is put on translational applied research for the development and validation of novel properly functionalized luminescent conjugated polymers (LCP) that via modern imaging technology can give rise to entirely new and innovative methodology for studying neurodegenerative diseases. The objectives include the development of novel imaging agents that can be utilized for biomedical research, diagnosis, monitoring and prognosis, and for support and guidance of therapeutic interventions for Alzheimer’s disease and prion diseases. The consortium is composed of expert groups in experimental optics, polymer synthesis, magnetic resonance imaging (MRI), synthesis of functionalized magnetic nanoparticles, amyloid structure, AD mouse models, clinical AD, and prion diseases. At the same time this project establishes strategic links between mainly SME based Industries, expert researchers at universities and principal users in terms of hospitals. The project consortium will develop and share an efficient plan for dissemination and exploitation of the project results.'

Introduzione (Teaser)

Diagnostic and therapeutic modalities that can elucidate the dynamics of the pathological processes implicated in Alzheimer's disease (AD) and prion diseases are much needed. By exploiting the properties of luminescent polymers, European scientists managed to translate biomolecular interactions into a real-time imaging modality.