PIROVAC

Improvement of current and development of new vaccines for theileriosis and babesios of small ruminants

 Coordinatore FORSCHUNGSZENTRUM BORSTEL 

 Organization address address: Parkallee 1-40
city: BORSTEL
postcode: 23845

contact info
Titolo: Prof.
Nome: Jabbar
Cognome: Ahmed
Email: send email
Telefono: 4945370000000
Fax: 4945370000000

 Nazionalità Coordinatore Germany [DE]
 Totale costo 4˙059˙031 €
 EC contributo 2˙999˙994 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2009-3
 Funding Scheme CP-FP-SICA
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-04-01   -   2014-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM BORSTEL

 Organization address address: Parkallee 1-40
city: BORSTEL
postcode: 23845

contact info
Titolo: Prof.
Nome: Jabbar
Cognome: Ahmed
Email: send email
Telefono: 4945370000000
Fax: 4945370000000

DE (BORSTEL) coordinator 835˙890.00
2    UNIVERSITY OF GLASGOW

 Organization address address: University Avenue
city: GLASGOW
postcode: G12 8QQ

contact info
Titolo: Prof.
Nome: Brian
Cognome: Shiels
Email: send email
Telefono: 441413000000
Fax: 441413000000

UK (GLASGOW) participant 254˙500.00
3    THE ROYAL VETERINARY COLLEGE

 Organization address address: Royal College Street
city: LONDON
postcode: NW10TU

contact info
Titolo: Mr.
Nome: Turhan
Cognome: Alasya
Email: send email
Telefono: +44 207 468 5207
Fax: +44 207 468

UK (LONDON) participant 200˙000.00
4    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: 441317000000
Fax: 441317000000

UK (EDINBURGH) participant 200˙000.00
5    BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN

 Organization address address: BERNHARD NOCHT STRASSE 74
city: HAMBURG
postcode: 20359

contact info
Titolo: Dr.
Nome: Volker
Cognome: Heussler
Email: send email
Telefono: 494043000000
Fax: 494043000000

DE (HAMBURG) participant 180˙000.00
6    LANZHOU VETERINARY RESEARCH INSTITUTE

 Organization address address: Xujiaping 11
city: "Lanzhou, Gansu"
postcode: 730046

contact info
Titolo: Prof.
Nome: Hong
Cognome: Yin
Email: send email
Telefono: 869318000000
Fax: 869318000000

CN ("Lanzhou, Gansu") participant 180˙000.00
7    Intervet International B.V.

 Organization address address: WIM DE KORVERSTRAAT 35
city: BOXMEER
postcode: 5831 AN

contact info
Titolo: Prof.
Nome: Theo
Cognome: Schetters
Email: send email
Telefono: +31 485 587327
Fax: +31 485 585313

NL (BOXMEER) participant 179˙104.00
8    PARCO TECNOLOGICO PADANO S.R.L.

 Organization address address: Via Einstein - Localita Cascina Codazza
city: LODI
postcode: 26900

contact info
Titolo: Dr.
Nome: Gianluca
Cognome: Carenzo
Email: send email
Telefono: 3903710000000
Fax: 3903710000000

IT (LODI) participant 170˙000.00
9    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mrs.
Nome: Annick
Cognome: Bertault
Email: send email
Telefono: 33140784901
Fax: 33140784998

FR (PARIS) participant 150˙000.00
10    UNIVERSITAET BERN

 Organization address address: Hochschulstrasse 4
city: BERN
postcode: 3012

contact info
Titolo: Prof.
Nome: Dirk Albert Eduard
Cognome: Dobbelaere
Email: send email
Telefono: 41316312625
Fax: +41 31 6212658

CH (BERN) participant 150˙000.00
11    ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE

 Organization address address: Site de la Chantrerie, Route de Gachet
city: NANTES
postcode: 44307

contact info
Titolo: Prof.
Nome: Alain
Cognome: Chauvin
Email: send email
Telefono: +33 240687698
Fax: +33 240687751

FR (NANTES) participant 130˙000.00
12    INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA

 Organization address address: Av. da Republica, Quinta do Marques S/N
city: OEIRAS
postcode: 2781901

contact info
Titolo: Dr.
Nome: Nuno
Cognome: Santos
Email: send email
Telefono: +351 21 442 7787
Fax: +351 21 442 1161

PT (OEIRAS) participant 130˙000.00
13    INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA

 Organization address address: Rivadavia 1439
city: BUENOS AIRES
postcode: 1033

contact info
Titolo: Mr.
Nome: Ezequiel
Cognome: Duffard
Email: send email
Telefono: 541146000000
Fax: 541146000000

AR (BUENOS AIRES) participant 100˙000.00
14    MINISTRY OF AGRICULTURE AND RURAL DEVELOPMENT

 Organization address address: .
city: BEIT DAGAN
postcode: 50250

contact info
Titolo: Dr.
Nome: Varda
Cognome: Shkap
Email: send email
Telefono: 97239681758
Fax: 97239681678

IL (BEIT DAGAN) participant 80˙500.00
15    ADNAN MENDERES UNIVERSITESI

 Organization address address: "Adnan Menderes Universitesi Rektorlugu, Merkez Kampus Aytepe Mvkii"
city: AYDIN
postcode: 9010

contact info
Titolo: Dr.
Nome: Tulin
Cognome: Karagenc
Email: send email
Telefono: 902562000000000
Fax: 902562000000

TR (AYDIN) participant 60˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

lestoquardi    parasite    subunit    vaccine    attenuated    diseases    small    cells    tick    activation    ruminants    goals    combination    food    borne    killing    caused    vaccines    molecules   

 Obiettivo del progetto (Objective)

'The proposal deals with the establishment of control measures for two major tick-borne diseases of small ruminants: theileriosis caused by Theileria lestoquardi and T. uilenbergi and babesiosis caused by Babesia ovis. The research programme aims at improving existing and producing new attenuated vaccines, designing subunit vaccines and capability building. To achieve these goals the proposal will assess parasite diversity and identify molecules associated with attenuation of parasite virulence to be included in the development of safe and efficacious live vaccines. For the design of a subunit vaccine parasite molecules will be identified and characterized involved in i) invasion of host cells ii) activation of CD4 T cells and NK cells for the production of cytokines capable of activating macrophages for killing of the parasites and iii) activation of cytotoxic T-lymphocytes involved in killing of T. lestoquardi-infected leucocytes. For improvement of attenuated vaccines, a combination of vaccine with subunit vaccine will be examined for synergistic effects and reducing the need of a cold chain by improving storage conditions/ shelf life of vaccine will be aimed for. Groups working on Plasmodium are involved with the goal to benefit from the scientific and technological knowledge in this field and to translate it into tools and reagents for small ruminant piroplasms. Industrial expertise regarding vaccine development and delivery systems will be incorporated in the whole project. The impact of the vaccine to be produced against these emerging tick-borne diseases will be enormous, as they pose a great threat to livestock production, and a contribution will be made that will meet critical Millennium development goals: food security, food safety, poverty alleviation, animal welfare and environmental sustainability.'

Introduzione (Teaser)

Tick-borne parasitic infections are common in small ruminants such as sheep, goats, deer and other related species. Through a combination of immunology, genomics and vaccinology, researchers from 11 countries investigated ways to improve existing vaccines and create new ones.

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