EU H2020 Project "NANOVOLTSENS (Voltage-sensing nanorods for super-resolution voltage imaging in neurons)": description, partecipants, costs and EC-fundings

#	Pagina
attuale pagina	/open-h2020/projects/209367/index.html
-1	/open-h2020/projects/222664/index.html
-2	/open-h2020/projects/197182/index.html
-3	/open-consip/fornitori/2018/profilo-01476690399/index.html
-4	/open-h2020/projects/211844/index.html
-5	/open-h2020/projects/205987/index.html
-6	/open-h2020/projects/196305/index.html
-7	/open-h2020/projects/199354/index.html
-8	/open-h2020/projects/203163/index.html
-9	/open-h2020/projects/195506/index.html

NanoVoltSens project word cloud

Explore the words cloud of the NanoVoltSens project. It provides you a very rough idea of what is the project "NanoVoltSens" about.

targetable invasively affords preliminary ratiometric lagging infrared dendritic self anastasia validate brain conductor multiple data certain performance single antoine paris decade morphology spikes triller vsnrs neuronal individual ibens excellent last ones sensing signal characterization temporal exceptional fluctuations imaging advantage neurobiology sites integration innovative ns accomplished sensor neurons calcium advantages tools near branch function optical red brightness applicable sensors detection potentials designed electrical dynamics significantly initial rods laboratory sensitivity resolution dr insert molecular particle voltage calibrate spines shift fundamentally optically record fast spatial semi shifted points action times ludwig spine emission nanorods extensive view simultaneously membrane spectral

Project "NanoVoltSens" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://weisslab.ph.biu.ac.il/
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2019-04-30

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE	FR (PARIS)	coordinator	185˙076.00

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

FR (PARIS)

coordinator

185˙076.00

Project objective

In the last decade, the rapidly developing optical imaging field has significantly improved our understanding of information processing in the brain. Although a number of promising tools have been designed, sensors of membrane potential are lagging behind. In this project we aim to characterize an innovative voltage sensor for neurons that is fundamentally different from the existing ones. Our sensor is based on targetable voltage-sensing semi-conductor nanorods (vsNRs) that self-insert into the neuronal membrane. The rods optically and non-invasively record action potentials at the single particle level, at multiple sites, and across a large field-of-view. Such vsNRs offer unique advantages, including: (1) large voltage sensitivity, (2) ratiometric imaging based on a large spectral shift as function of voltage, (3) very fast response times in the range of ns, (4) very high brightness that affords single-particle detection, and (5) excellent performance in the near-infrared spectral range. The goal of this project is to validate, calibrate, and use vsNRs in neurons, focusing on dendritic spines and dendritic voltage spikes. After initial characterization of vsNRs in neurons, we will take advantage of the exceptional spatial and temporal resolution provided by vsNRs in order to access electrical properties of individual dendritic spines, as well as to make use of the red-shifted emission of vsNRs in order to record simultaneously membrane potential and calcium fluctuations at dendritic branch points. The project is to be accomplished in the laboratory of Dr. Antoine Triller at the IBENS, Paris by Dr. Anastasia Ludwig, who has extensive experience in molecular neurobiology, including analysis of dendritic spine morphology and dynamics. Based on our preliminary data, we are certain to be able to provide within two years a viable and user-friendly voltage-imaging technology that will be widely applicable for the study of signal integration in the brain.

Publications

List of publications.
year	authors and title	journal	last update
2017	Omri Bar-Elli, Dan Steinitz, Gaoling Yang, Ron Tenne, Anastasia Ludwig, Yung Kuo, Antoine Triller, Shimon Weiss, Dan Oron Rapid Voltage Sensing with Single Nanorods via the Quantum Confined Stark Effect published pages: 2860-2867, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b00206	ACS Photonics 5/7	2019-09-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANOVOLTSENS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NANOVOLTSENS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TCFLAND2SEA (2020)

Thawing Carbon From LAND to SEA: Microbial Degradation of Organic Matter and Response to Thawing Permafrost in the Northeast Siberian Land-Shelf System