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NanoVoltSens

Voltage-sensing nanorods for super-resolution voltage imaging in neurons

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 NanoVoltSens project word cloud

Explore the words cloud of the NanoVoltSens project. It provides you a very rough idea of what is the project "NanoVoltSens" about.

ibens    view    spines    dendritic    targetable    triller    spatial    conductor    dr    fundamentally    spikes    ludwig    calcium    individual    times    calibrate    imaging    certain    tools    excellent    self    near    action    antoine    vsnrs    ratiometric    temporal    insert    preliminary    neuronal    fluctuations    branch    accomplished    characterization    morphology    molecular    shifted    sites    optically    record    ones    applicable    multiple    lagging    semi    initial    anastasia    red    spine    neurobiology    exceptional    sensor    spectral    advantage    infrared    brightness    dynamics    detection    sensors    resolution    optical    paris    significantly    particle    data    extensive    potentials    integration    electrical    nanorods    sensitivity    brain    ns    invasively    membrane    designed    signal    innovative    advantages    fast    laboratory    affords    shift    validate    function    last    sensing    single    voltage    simultaneously    neurons    performance    rods    points    emission    decade   

Project "NanoVoltSens" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Project website http://weisslab.ph.biu.ac.il/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

In the last decade, the rapidly developing optical imaging field has significantly improved our understanding of information processing in the brain. Although a number of promising tools have been designed, sensors of membrane potential are lagging behind. In this project we aim to characterize an innovative voltage sensor for neurons that is fundamentally different from the existing ones. Our sensor is based on targetable voltage-sensing semi-conductor nanorods (vsNRs) that self-insert into the neuronal membrane. The rods optically and non-invasively record action potentials at the single particle level, at multiple sites, and across a large field-of-view. Such vsNRs offer unique advantages, including: (1) large voltage sensitivity, (2) ratiometric imaging based on a large spectral shift as function of voltage, (3) very fast response times in the range of ns, (4) very high brightness that affords single-particle detection, and (5) excellent performance in the near-infrared spectral range. The goal of this project is to validate, calibrate, and use vsNRs in neurons, focusing on dendritic spines and dendritic voltage spikes. After initial characterization of vsNRs in neurons, we will take advantage of the exceptional spatial and temporal resolution provided by vsNRs in order to access electrical properties of individual dendritic spines, as well as to make use of the red-shifted emission of vsNRs in order to record simultaneously membrane potential and calcium fluctuations at dendritic branch points. The project is to be accomplished in the laboratory of Dr. Antoine Triller at the IBENS, Paris by Dr. Anastasia Ludwig, who has extensive experience in molecular neurobiology, including analysis of dendritic spine morphology and dynamics. Based on our preliminary data, we are certain to be able to provide within two years a viable and user-friendly voltage-imaging technology that will be widely applicable for the study of signal integration in the brain.

 Publications

year authors and title journal last update
List of publications.
2017 Omri Bar-Elli, Dan Steinitz, Gaoling Yang, Ron Tenne, Anastasia Ludwig, Yung Kuo, Antoine Triller, Shimon Weiss, Dan Oron
Rapid Voltage Sensing with Single Nanorods via the Quantum Confined Stark Effect
published pages: 2860-2867, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b00206 		ACS Photonics 5/7 2019-09-25

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