SYNSYS

Synaptic Systems: dissecting brain function in health and disease

 Coordinatore STICHTING VU-VUMC 

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Dr.
Nome: Yvonne
Cognome: Kops
Email: send email
Telefono: +31 20 5987304

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.synsys.eu/
 Totale costo 14˙327˙877 €
 EC contributo 10˙739˙837 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-two-stage
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-07-01   -   2014-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    STICHTING VU-VUMC

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Dr.
Nome: Yvonne
Cognome: Kops
Email: send email
Telefono: +31 20 5987304

NL (AMSTERDAM) coordinator 2˙072˙800.00
2    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Nils
Cognome: Brose
Email: send email
Telefono: +49 5513899727
Fax: +49 5513899715

DE (MUENCHEN) participant 1˙341˙200.00
3    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 131 650 9024
Fax: +44 131 651 4028

UK (EDINBURGH) participant 1˙252˙740.20
4    MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT

 Organization address address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125

contact info
Titolo: Ms.
Nome: Andrea
Cognome: Winnefeld
Email: send email
Telefono: +49 30 94062363
Fax: +49 30 94062552

DE (BERLIN) participant 670˙620.00
5 KOBENHAVNS UNIVERSITET DK participant 532˙800.00
6    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Prof.
Nome: Oleg
Cognome: Shupliakov
Email: send email
Telefono: +46 852487849
Fax: +46 8325861

SE (STOCKHOLM) participant 529˙200.00
7    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Mihaja
Cognome: Auguste
Email: send email
Telefono: +33 1 48073415
Fax: +33 1 48073432

FR (PARIS) participant 523˙200.00
8    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Rik
Cognome: Audenaert
Email: send email
Telefono: +32 92446611
Fax: +32 92446610

BE (ZWIJNAARDE - GENT) participant 520˙800.00
9    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Dr.
Nome: Robert
Cognome: Preissner
Email: send email
Telefono: +49 308445 1649
Fax: +49 308445 1551

DE (BERLIN) participant 468˙000.00
10    Brainwave-Discovery Limited

 Organization address address: Main Street Ardshiel
city: Gartmore
postcode: FK8 3RJ

contact info
Titolo: Prof.
Nome: Wayne
Cognome: Davies
Email: send email
Telefono: +44 1877382457
Fax: +44 8719004075

UK (Gartmore) participant 452˙400.00
11    SYNAPTOLOGICS BV

 Organization address address: BURMANSTRAAT 7
city: AMSTERDAM
postcode: 1091 SG

contact info
Titolo: Ms.
Nome: Annemieke A.
Cognome: Steenbergen
Email: send email
Telefono: +31 205983555
Fax: +31 205987112

NL (AMSTERDAM) participant 445˙576.00
12    BEACTICA AB

 Organization address address: Box 567
city: UPPSALA
postcode: 751 22

contact info
Titolo: Dr.
Nome: Per
Cognome: Källblad
Email: send email
Telefono: +46 18560880
Fax: +46 18506808

SE (UPPSALA) participant 444˙594.00
13    Synome Ltd

 Organization address address: MONETA BUILDING BABRAHAM RESEARCH CAMPUS
city: Cambridge
postcode: CB22 3AT

contact info
Titolo: Mr.
Nome: Troels
Cognome: Jordansen
Email: send email
Telefono: +44 1223352200
Fax: +44 1223281399

UK (Cambridge) participant 435˙603.00
14    HELSINGIN YLIOPISTO

 Organization address address: YLIOPISTONKATU 4
city: HELSINGIN YLIOPISTO
postcode: 14

contact info
Titolo: Ms.
Nome: Kaisa
Cognome: Ainala
Email: send email
Telefono: +358 919125043
Fax: +358 9 191 25044

FI (HELSINGIN YLIOPISTO) participant 385˙860.00
15    THE BABRAHAM INSTITUTE

 Organization address address: Babraham Hall
city: CAMBRIDGE
postcode: CB22 3AT

contact info
Titolo: Mrs.
Nome: Fang
Cognome: Gao
Email: send email
Telefono: +44 123496000

UK (CAMBRIDGE) participant 338˙011.50
16    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Tom
Cognome: Ratcliff
Email: send email
Telefono: +44 1223 492528
Fax: +44 1223 494 468

DE (HEIDELBERG) participant 294˙388.50
17    GENOME RESEARCH LIMITED

 Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Prof.
Nome: Seth
Cognome: Grant
Email: send email
Telefono: +44 131 650 4492
Fax: +44 1223494919

UK (LONDON) participant 32˙043.76
18    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Mr.
Nome: Sander
Cognome: Jansen
Email: send email
Telefono: +31 20 5982944
Fax: +31 20 5989281

NL (AMSTERDAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

generate    genes    people    central    dynamic    disorders    transmission    human    therapies    model    synaptic    molecular    predictions    cns    function    affect    quantitative    nervous    brain    synsys    disease    signalling    physiology    synapse    modeling    proteins   

 Obiettivo del progetto (Objective)

'Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and the complexity of the underlying signalling complexes pose a significant challenge to dissecting the molecular mechanisms of disease and to design efficient drugs. SynSys assembles leading European laboratories to provide the expertise and established research platforms that uniquely enable a systems-level analysis of synaptic signalling. The consortium features a closed loop from data integration and modelling, human genetics, physiology, proteomics and the application of engineered model systems to test model predictions. The main objectives of this project are to (i) provide a qualitative and quantitative description of the protein composition and the interactome of the mammalian glutamatergic synapse that integrates known human variation in these genes, (ii) to generate quantitative dynamic models describing the main functional features of the synaptic system, (iii) to reiterate on modeling by relating model predictions to synaptic function, (iv) to identify and validate, using appropriate model systems, human vulnerability genes that may form the basis of future therapies. Only a Systems level analysis can provide the means to describe synaptic transmission from molecule to function, its dynamics in relation to physiology and, brain function and brain disorders. As such, SynSys will establish a new platform for iterative molecular analysis of synapse function and dynamic modeling, with the perspective to generate a blueprint for discovery of novel pathways and targets that enable rational strategies to design therapies for human brain disease.'

Introduzione (Teaser)

Synapses are at the very root of nerve transmission. As such, they are the main reason for major disorders of the central nervous system (CNS) that affect a third of people worldwide.

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