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GUMS AND JOINTS

Protein citrullination as a link between periodontal diseases and rheumatoid arthritis (RA) and target for development of novel drugs to treat RA

Coordinatore	UNIVERSITETET I BERGEN Organization address address: Museplassen 1 city: BERGEN postcode: 5007 contact info Titolo: Mr. Nome: Liv-Grethe Cognome: Gudmundsen Email: send email Telefono: +47 55584965 Fax: +47 55584991
Nazionalità Coordinatore	Norway [NO]
Sito del progetto	http://www.gumsandjoints.com
Totale costo	7˙588˙334 €
EC contributo	5˙851˙588 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2010-single-stage
Funding Scheme	CP-FP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-11-01 - 2014-10-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITETET I BERGEN Organization address address: Museplassen 1 city: BERGEN postcode: 5007 contact info Titolo: Mr. Nome: Liv-Grethe Cognome: Gudmundsen Email: send email Telefono: +47 55584965 Fax: +47 55584991	NO (BERGEN)	coordinator	705˙849.00
2	4 SC AG Organization address address: Am Klopferspitz 19 a city: Planegg-Martinsried postcode: 82152 contact info Titolo: Mr. Nome: Enno Cognome: Spillner Email: send email Telefono: +49 89 7007630 Fax: +49 89 7007629	DE (Planegg-Martinsried)	participant	703˙985.60
3	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Caroline Cognome: Hamilton Email: send email Telefono: +46 8 51775959 Fax: +46 8 337394	SE (STOCKHOLM)	participant	545˙993.80
4	UNIVERSITY OF GLASGOW Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Mr. Nome: Joe Cognome: Galloway Email: send email Telefono: +44 141 330 3844 Fax: +44 141 330 5856	UK (GLASGOW)	participant	542˙663.80
5	UNIWERSYTET JAGIELLONSKI Organization address address: Ul. Golebia 24 city: KRAKOW postcode: 31007 contact info Titolo: Ms. Nome: Agata Cognome: Potempa Email: send email Telefono: +48 12 664 6343 Fax: +4812 664 6209	PL (KRAKOW)	participant	541˙741.50
6	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	participant	514˙057.60
7	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Eusebio Cognome: Jimenez Arroyo Email: send email Telefono: +34 91 566 8852 Fax: +34 91 566 8913	ES (MADRID)	participant	503˙266.60
8	GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Dr. Nome: Emilia Cognome: Rung Email: send email Telefono: +46 31 7865238 Fax: +46 31 7864355	SE (GOETEBORG)	participant	498˙729.60
9	THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Mr. Nome: Robert Cognome: Fekete Email: send email Telefono: +44 121 415 8202 Fax: +44 121 414 6056	UK (BIRMINGHAM)	participant	447˙759.80
10	UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 contact info Titolo: Prof. Nome: Pier Remigio Cognome: Salvi Email: send email Telefono: +39 55 457 3084 Fax: +39 055 457 3385	IT (Florence)	participant	433˙146.70
11	AARHUS UNIVERSITET Organization address address: Nordre Ringgade 1 city: AARHUS C postcode: 8000 contact info Nome: Leth Stentov Cognome: Pernille Email: send email Telefono: +45 89425057 Fax: +45 89423596	DK (AARHUS C)	participant	253˙504.80
12	ANAXOMICS BIOTECH, S.L. Organization address address: CALLE BALMES (PISO 4 - PTA 2A) 89 city: Barcelona postcode: 8008 contact info Titolo: Ms. Nome: Vesna Cognome: Radovanovic Email: send email Telefono: +34 934 516 717 Fax: +34 610 742 196	ES (Barcelona)	participant	160˙889.20
13	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Tatjana Cognome: Palalic Email: send email Telefono: +44 020 7594 3866 Fax: +44 020 8383 4499	UK (LONDON)	participant	0.00

Mappa

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citrullinated rheumatoid characterised pd p ra pathogenic link proteins genetic arthritis risk periodontitis context gingivalis autoimmunity antibody chronic

Obiettivo del progetto (Objective)

'Autoimmunity in rheumatoid arthritis (RA) is characterised by an antibody response to citrullinated proteins. Periodontitis (PD) is largely caused by infection, in which Porphyromonas gingivalis is a major pathogen. The two diseases combine specific HLA-DRB1alleles and smoking as risk factors, and have a similar pathophysiology characterised by destructive inflammation. A possible causative link between RA and PD is based on the ability of P. gingivalis to citrullinate proteins and thereby generate autoantigens that drive autoimmunity in RA. We hypothesise that anti-citrullinated protein antibodies can be generated, in genetically susceptible individuals, as a consequence of P. Gingivalis-induced citrullination in the gingiva. In the context of genetic risk factors, during chronic exposure to danger signals, such as bacterial lipopolysacharides and DNA, tolerance to citrullinated proteins may be broken, with production of a pathogenic antibody response, which at a later time point cross-reacts with joint proteins and causes chronic RA. We will use a multidisciplinary approach (genetics, epidemiology, molecular immunology and animal models) to study susceptibility factors and immune responses in RA and PD, with an aim to identify novel etiological and pathogenic pathways, forming the basis for new therapies.'

Introduzione (Teaser)

Identification of the epidemiological, genetic and environmental triggers of rheumatoid arthritis (RA) will aid the design of therapeutic interventions. In this context, European scientists discovered a link between RA and periodontitis (PD).