CELL-PID

Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency

 Coordinatore UNIVERSITA VITA-SALUTE SAN RAFFAELE 

 Organization address address: Via Olgettina 58
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: 390226000000
Fax: +39 02 26433781

 Nazionalità Coordinatore Italy [IT]
 Totale costo 15˙799˙071 €
 EC contributo 11˙887˙735 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2010-single-stage
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-11-01   -   2015-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA VITA-SALUTE SAN RAFFAELE

 Organization address address: Via Olgettina 58
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: 390226000000
Fax: +39 02 26433781

IT (MILANO) coordinator 1˙431˙584.08
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Annick
Cognome: Bertault
Email: send email
Telefono: +33 140 784 901
Fax: +33 140 784 998

FR (PARIS) participant 1˙415˙500.00
3    MEDIZINISCHE HOCHSCHULE HANNOVER

 Organization address address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625

contact info
Titolo: Mr.
Nome: Frank
Cognome: Dittrich
Email: send email
Telefono: +49 511 532 5343
Fax: +49 511 532 4253

DE (HANNOVER) participant 1˙346˙634.00
4    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: +44 20 3108 3033
Fax: +44 20 7813 2849

UK (LONDON) participant 1˙195˙287.00
5    Fondazione Centro San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845
Fax: +39 02 2643 4717

IT (Milano) participant 1˙146˙169.92
6    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Prof.
Nome: Gerard
Cognome: Wagemaker
Email: send email
Telefono: +31 10 704 3766
Fax: +31 10 704 4745

NL (ROTTERDAM) participant 791˙531.64
7    MOLECULAR MEDICINE SPA

 Organization address address: VIA OLGETTINA 58
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Enrico
Cognome: Cappelli
Email: send email
Telefono: +39 0221277 302
Fax: +39 0221277 353

IT (MILANO) participant 678˙270.00
8    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Georg-A
Cognome: Hollaender
Email: send email
Telefono: +41 61 695 30 71
Fax: +41 61 695 30 70

CH (BASEL) participant 557˙538.00
9    OSPEDALE PEDIATRICO BAMBINO GESU

 Organization address address: PIAZZA SAN ONOFRIO 4
city: ROMA
postcode: 165

contact info
Titolo: Dr.
Nome: Sonya Jane
Cognome: Martin
Email: send email
Telefono: +39 06 6859 2497
Fax: +39 06 6859 2101

IT (ROMA) participant 539˙995.00
10    CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG

 Organization address address: PAUL EHRLICH STRASSE 42-44
city: FRANKFURT
postcode: 60596

contact info
Titolo: Dr.
Nome: Manuel
Cognome: Grez
Email: send email
Telefono: +49 69 63395113
Fax: +49 60 63395297

DE (FRANKFURT) participant 516˙199.00
11    WEIZMANN INSTITUTE OF SCIENCE

 Organization address address: HERZL STREET 234
city: REHOVOT
postcode: 7610001

contact info
Titolo: Ms.
Nome: Talia
Cognome: Tzahor
Email: send email
Telefono: +972 8 934 4026
Fax: +972 8 934 4165

IL (REHOVOT) participant 437˙794.00
12    MILTENYI BIOTEC GMBH

 Organization address address: FRIEDRICH EBERT STRASSE 68
city: BERGISCH GLADBACH
postcode: 51429

contact info
Titolo: Ms.
Nome: Sabrina
Cognome: Schmitz
Email: send email
Telefono: +49 2204 8306 4497
Fax: +49 2204 85197

DE (BERGISCH GLADBACH) participant 395˙720.00
13    TECHNISCHE UNIVERSITAET DRESDEN

 Organization address address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069

contact info
Titolo: Dr.
Nome: Lars
Cognome: Henning
Email: send email
Telefono: +49 351 463 42185
Fax: +49 351 463 39742

DE (DRESDEN) participant 361˙240.00
14    HACETTEPE UNIVERSITESI

 Organization address address: HACETTEPE UNIVERSITESI BEYTEPE KAMPUSU REKTORLUK BINASI
city: CANKAYA ANKARA
postcode: 6800

contact info
Titolo: Ms.
Nome: Sevtap
Cognome: Benl?
Email: send email
Telefono: +90 312 305 2191
Fax: +90 312 311 7906

TR (CANKAYA ANKARA) participant 355˙974.36
15    GATC BIOTECH AG

 Organization address address: JAKOB STADLER PLATZ 7
city: KONSTANZ
postcode: 78467

contact info
Titolo: Ms.
Nome: Natascha
Cognome: Ostrowski
Email: send email
Telefono: +49 7531 81 60 47
Fax: +49 7531 81 60 947

DE (KONSTANZ) participant 289˙400.00
16    FINOVATIS

 Organization address address: COURS LAFAYETTE 68
city: LYON
postcode: 69003

contact info
Titolo: Dr.
Nome: David
Cognome: Koubi
Email: send email
Telefono: +33 478547940
Fax: +33 472336517

FR (LYON) participant 276˙900.00
17    EUROPAEISCHES INSTITUT FUER FORSCHUNG UND ENTWICKLUNG VON TRANSPLANTATIONSSTRATEGIEN GMBH

 Organization address address: Vollmersbachstrasse 66
city: IDAR-OBERSTEIN
postcode: 55743

contact info
Titolo: Dr.
Nome: Klaus
Cognome: Kuehlcke
Email: send email
Telefono: +49 678 198 550
Fax: +49 678 198 55237

DE (IDAR-OBERSTEIN) participant 49˙998.00
18    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Mr.
Nome: Ivo
Cognome: Cotti
Email: send email
Telefono: +41 44 266 76 32
Fax: +41 44 266 71 62

CH (ZURICH) participant 49˙998.00
19    EUROPESE VERENIGING VOOR GEN- EN CELTHERAPIE IVZW

 Organization address address: TIENSESTEENWEG 250
city: BIERBEEK
postcode: 3360

contact info
Titolo: Ms.
Nome: Renee
Cognome: Watson
Email: send email
Telefono: +44 790 323 30 64
Fax: +44 790 323 30 64

BE (BIERBEEK) participant 27˙002.00
20    EUROPEAN GROUP FOR BLOOD AND MARROW TRANSPLANTATION

 Organization address address: P. DEBYELAAN-HAEMATOLOGIE
city: MAASTRICHT
postcode: 6229HX

contact info
Titolo: Mr.
Nome: Marco
Cognome: Van Der Most
Email: send email
Telefono: 31107034913
Fax: +31 10 7034803

NL (MAASTRICHT) participant 25˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    preclinical    modified    patients    gene    deficiencies    allogeneic    medicinal    hsct       therapy    genetically    immune    multicentre    pid    scid    ada    primary    cells    clinical    stem    healthy    corrected    pids    hsc    disorders    treatment    trials    cancer   

 Obiettivo del progetto (Objective)

'Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ADA-SCID have been successfully treated with autologous gene corrected HSC, however, associated with safety issues inherent to first generation retroviral vectors. This project utilizes genetically modified HSC and their descendants as immunotherapeutic cells to build a healthy immune system in PID patients, and is carried out by clinical centres, scientists and industrial partners pioneering in the field of advanced therapies and aiming at broad clinical application of safe cell-based therapeutic products. Multicentre phase I/II clinical trials for SCID-X1 and WAS are ready to start. Disease targeted technology to cure ADA-SCID, V(D)J recombination defects and CGD by gene corrected HSC and novel approaches in IPEX and HLH to gene modify already committed cells will be investigated. Based on rigorous preclinical efficacy and toxicology evaluation, flanked by basic studies aimed at improving HSC homing capacity and thymic epithelium regeneration, new clinical trials will be implemented. The consortium will establish a technology platform to implement, harmonize and run controlled, standardized multicentre preclinical studies using state-of-the-art advanced therapy. Strict observance of good practice quality guidelines and regulation of medicinal product development will be ensured. The successful completion of the project will be instrumental to accomplish and broaden clinical application of medicinal products able to rebuild and modulate the immune system with an anticipated impact that extends beyond PID to acquired immune disorders, allogeneic HSCT and cancer treatment.'

Introduzione (Teaser)

An EU-funded study aims to restore the faith in of the use of gene therapy for treatment of primary immune deficiencies (PIDs). The CELL-PID project utilises genetically modified haematopoietic stem cells (HSCs) as a cell-based therapy for building a healthy immune system in patients with PIDs.

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