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DIAGORAS

Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 DIAGORAS project word cloud

Explore the words cloud of the DIAGORAS project. It provides you a very rough idea of what is the project "DIAGORAS" about.

setup    crowded    point    disc    equally    multiplexed    fabrication    age    innovative    reader    periodontitis    dna    proteins    quantitative    sinusitis    interface    molecular    heart    physicians    elderly    socioeconomic    nucleic    progressed    treatments    diseases    diagnosing    components    hospitals    bead    producible    isolation    tonsillitis    assays    stage    microarray    protein    entire    batch    patients    acid    rapid    microfluidic    too    polymer    settings    render    microthermoforming    viral    pcr    units    salivary    markers    vs    tract    offices    platform    detected    treatment    sampling    automated    validated    affordable    host    spent    disposable    monitoring    extraction    healthcare    caries    community    culture    amplification    integrating    schools    rna    respiratory    foils    invasive    preparation    buffers    chair    tube    lies    largely    immunoassays    antibiotics    modular    personalized    differentiation    purification    efficient    excessive    bacterial    resistance    stored    screening    rtis    answer    insurance    detection    gold    labdisk    diagnosed    benefit    antibiotic    collection    centrifugal    tissue    prevention    care    disease    diagoras    diagnosis    rhinitis    standards    clinical    infections    budget    pharyngitis    nature    oral   

Project "DIAGORAS" data sheet

The following table provides information about the project.

Coordinator
HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. 

Organization address
address: WILHELM-SCHICKARD-STRASSE 10
city: Villingen
postcode: 78052
website: www.hsg-imit.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.diagoras.eu
 Twitter https://twitter.com/diagoraseu
 Total cost 5˙588˙101 €
 EC max contribution 4˙721˙198 € (84%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. DE (Villingen) coordinator 985˙378.00
2    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 819˙016.00
3    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) participant 749˙531.00
4    BIOVENDOR - LABORATORNI MEDICINA AS CZ (BRNO) participant 625˙308.00
5    Askion GmbH DE (GERA) participant 499˙250.00
6    CLINICAGENO LIMITED UK (COULSDON SURREY) participant 436˙208.00
7    MAGNAMEDICS DIAGNOSTICS BV NL (GELEEN) participant 398˙317.00
8    SPARKS & CO FR (PARIS) participant 121˙563.00
9    MAGTIVIO B.V. NL (Heerlen) participant 70˙432.00
10    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 16˙191.00
11    UNIVERSITAT ZURICH CH (ZURICH) participant 0.00

Map

 Project objective

The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g., tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g., tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features.

 Deliverables

List of deliverables.
D9.2 Questionnaires from EMC and UZH(PPC) for clinician, GP, and dentist feedback Documents, reports 2020-02-26 16:30:53
D10.7 Project-related video Websites, patent fillings, videos etc. 2020-02-26 16:30:53
D10.6 Two workshops organised at partners EMC, UZH and KI Websites, patent fillings, videos etc. 2020-02-26 16:30:53
D10.3 Communication materials Websites, patent fillings, videos etc. 2020-02-26 16:30:52
D10.1 Project website and intranet Websites, patent fillings, videos etc. 2020-02-26 16:30:52

Take a look to the deliverables list in detail:  detailed list of DIAGORAS deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Alex van Belkum, Till T. Bachmann, Gerd Lüdke, Jan Gorm Lisby, Gunnar Kahlmeter, Allan Mohess, Karsten Becker, John P. Hays, Neil Woodford, Konstantinos Mitsakakis, Jacob Moran-Gilad, Jordi Vila, Harald Peter, John H. Rex, Wm. Michael Dunne
Developmental roadmap for antimicrobial susceptibility testing systems
published pages: 51-62, ISSN: 1740-1526, DOI: 10.1038/s41579-018-0098-9
Nature Reviews Microbiology 17/1 2020-02-26
2018 Konstantinos Mitsakakis, Wendy E Kaman, Gijs Elshout, Mara Specht, John P Hays
Challenges in identifying antibiotic resistance targets for point-of-care diagnostics in general practice
published pages: 1157-1164, ISSN: 1746-0913, DOI: 10.2217/fmb-2018-0084
Future Microbiology 13/10 2020-02-26
2017 Georgios N. Belibasakis, Michael A. Curtis, George Hajishengallis, Egija Zaura
Meeting report: The 12 th European oral microbiology workshop (EOMW) in Stockholm, Sweden
published pages: 64-69, ISSN: 2150-5594, DOI: 10.1080/21505594.2017.1376147
Virulence 9/1 2020-02-26
2017 John P Hays
Why is scientific research on ‘data-poor’ microorganisms being ignored?
published pages: 645-650, ISSN: 1746-0913, DOI: 10.2217/fmb-2017-0061
Future Microbiology 12/8 2020-02-26
2017 Y. Zhao, G. Czilwik, V. Klein, K. Mitsakakis, R. Zengerle, N. Paust
C-reactive protein and interleukin 6 microfluidic immunoassays with on-chip pre-stored reagents and centrifugo-pneumatic liquid control
published pages: 1666-1677, ISSN: 1473-0197, DOI: 10.1039/c7lc00251c
Lab on a Chip 17/9 2020-02-26
2016 Wendy E Kaman, Gijs Elshout, Patrick JE Bindels, Konstantinos Mitsakakis, John P Hays
Current problems associated with the microbiological point-of-care testing of respiratory tract infections in primary care
published pages: 607-610, ISSN: 1746-0913, DOI: 10.2217/fmb-2015-0020
Future Microbiology 11/5 2020-02-26
2017 Annemiek A van der Eijk, Andrei N Tintu, John P Hays
Pre-implementation guidelines for infectious disease point-of-care testing in medical institutions
published pages: 51-58, ISSN: 1746-0913, DOI: 10.2217/fmb-2016-0120
Future Microbiology 12/1 2020-02-26

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The information about "DIAGORAS" are provided by the European Opendata Portal: CORDIS opendata.

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