DIAGORAS
Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment
Total Cost €
0EC-Contrib. €
0Partnership
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0DIAGORAS project word cloud
Explore the words cloud of the DIAGORAS project. It provides you a very rough idea of what is the project "DIAGORAS" about.
Project "DIAGORAS" data sheet
The following table provides information about the project.
| Coordinator |
HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v.
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://www.diagoras.eu |
| https://twitter.com/diagoraseu | |
| Total cost | 5˙588˙101 € |
| EC max contribution | 4˙721˙198 € (84%) |
| Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
| Code Call | H2020-PHC-2014-two-stage |
| Funding Scheme | RIA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2019-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. | DE (Villingen) | coordinator | 985˙378.00 |
| 2 | ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM | NL (ROTTERDAM) | participant | 819˙016.00 |
| 3 | AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH | AT (WIEN) | participant | 749˙531.00 |
| 4 | BIOVENDOR - LABORATORNI MEDICINA AS | CZ (BRNO) | participant | 625˙308.00 |
| 5 | Askion GmbH | DE (GERA) | participant | 499˙250.00 |
| 6 | CLINICAGENO LIMITED | UK (COULSDON SURREY) | participant | 436˙208.00 |
| 7 | MAGNAMEDICS DIAGNOSTICS BV | NL (GELEEN) | participant | 398˙317.00 |
| 8 | SPARKS & CO | FR (PARIS) | participant | 121˙563.00 |
| 9 | MAGTIVIO B.V. | NL (Heerlen) | participant | 70˙432.00 |
| 10 | KAROLINSKA INSTITUTET | SE (STOCKHOLM) | participant | 16˙191.00 |
| 11 | UNIVERSITAT ZURICH | CH (ZURICH) | participant | 0.00 |
Map
Project objective
The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g., tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g., tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features.
Deliverables
| D9.2 Questionnaires from EMC and UZH(PPC) for clinician, GP, and dentist feedback | Documents, reports | 2020-02-26 16:30:53 |
| D10.7 Project-related video | Websites, patent fillings, videos etc. | 2020-02-26 16:30:53 |
| D10.6 Two workshops organised at partners EMC, UZH and KI | Websites, patent fillings, videos etc. | 2020-02-26 16:30:53 |
| D10.3 Communication materials | Websites, patent fillings, videos etc. | 2020-02-26 16:30:52 |
| D10.1 Project website and intranet | Websites, patent fillings, videos etc. | 2020-02-26 16:30:52 |
Take a look to the deliverables list in detail: detailed list of DIAGORAS deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Alex van Belkum, Till T. Bachmann, Gerd Lüdke, Jan Gorm Lisby, Gunnar Kahlmeter, Allan Mohess, Karsten Becker, John P. Hays, Neil Woodford, Konstantinos Mitsakakis, Jacob Moran-Gilad, Jordi Vila, Harald Peter, John H. Rex, Wm. Michael Dunne Developmental roadmap for antimicrobial susceptibility testing systems published pages: 51-62, ISSN: 1740-1526, DOI: 10.1038/s41579-018-0098-9 |
Nature Reviews Microbiology 17/1 | 2020-02-26 |
| 2018 |
Konstantinos Mitsakakis, Wendy E Kaman, Gijs Elshout, Mara Specht, John P Hays Challenges in identifying antibiotic resistance targets for point-of-care diagnostics in general practice published pages: 1157-1164, ISSN: 1746-0913, DOI: 10.2217/fmb-2018-0084 |
Future Microbiology 13/10 | 2020-02-26 |
| 2017 |
Georgios N. Belibasakis, Michael A. Curtis, George Hajishengallis, Egija Zaura Meeting report: The 12 th European oral microbiology workshop (EOMW) in Stockholm, Sweden published pages: 64-69, ISSN: 2150-5594, DOI: 10.1080/21505594.2017.1376147 |
Virulence 9/1 | 2020-02-26 |
| 2017 |
John P Hays Why is scientific research on ‘data-poor’ microorganisms being ignored? published pages: 645-650, ISSN: 1746-0913, DOI: 10.2217/fmb-2017-0061 |
Future Microbiology 12/8 | 2020-02-26 |
| 2017 |
Y. Zhao, G. Czilwik, V. Klein, K. Mitsakakis, R. Zengerle, N. Paust C-reactive protein and interleukin 6 microfluidic immunoassays with on-chip pre-stored reagents and centrifugo-pneumatic liquid control published pages: 1666-1677, ISSN: 1473-0197, DOI: 10.1039/c7lc00251c |
Lab on a Chip 17/9 | 2020-02-26 |
| 2016 |
Wendy E Kaman, Gijs Elshout, Patrick JE Bindels, Konstantinos Mitsakakis, John P Hays Current problems associated with the microbiological point-of-care testing of respiratory tract infections in primary care published pages: 607-610, ISSN: 1746-0913, DOI: 10.2217/fmb-2015-0020 |
Future Microbiology 11/5 | 2020-02-26 |
| 2017 |
Annemiek A van der Eijk, Andrei N Tintu, John P Hays Pre-implementation guidelines for infectious disease point-of-care testing in medical institutions published pages: 51-58, ISSN: 1746-0913, DOI: 10.2217/fmb-2016-0120 |
Future Microbiology 12/1 | 2020-02-26 |
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