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DIAGORAS

Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

DIAGORAS project word cloud

Explore the words cloud of the DIAGORAS project. It provides you a very rough idea of what is the project "DIAGORAS" about.

settings batch rapid amplification benefit stored screening crowded progressed antibiotic efficient setup nucleic too antibiotics oral standards microarray clinical vs diseases answer modular host equally protein immunoassays centrifugal infections spent prevention rhinitis rtis collection caries integrating pharyngitis hospitals labdisk patients detection stage diagoras foils viral budget microthermoforming healthcare heart dna diagnosis tonsillitis differentiation diagnosing chair isolation interface markers largely treatments assays personalized sinusitis resistance insurance respiratory innovative affordable lies units acid invasive age bead molecular point platform disposable gold producible monitoring fabrication disc nature offices multiplexed disease entire components proteins extraction pcr buffers render automated preparation polymer excessive periodontitis purification diagnosed tract tube bacterial elderly quantitative schools community treatment socioeconomic detected reader rna culture physicians care sampling validated tissue salivary microfluidic

Project "DIAGORAS" data sheet

The following table provides information about the project.

Coordinator	HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. Organization address address: WILHELM-SCHICKARD-STRASSE 10 city: Villingen postcode: 78052 website: www.hsg-imit.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.diagoras.eu
Twitter	https://twitter.com/diagoraseu
Total cost	5˙588˙101 €
EC max contribution	4˙721˙198 € (84%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. Organization address address: WILHELM-SCHICKARD-STRASSE 10 city: Villingen postcode: 78052 website: www.hsg-imit.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Villingen)	coordinator	985˙378.00
2	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	819˙016.00
3	AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH Organization address address: GIEFINGGASSE 4 city: WIEN postcode: 1210 website: http://www.ait.ac.at/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	749˙531.00
4	BIOVENDOR - LABORATORNI MEDICINA AS BIOVENDOR - LABORATORNI MEDICINA AS Organization address address: KARASEK 1767/1 city: BRNO postcode: 621 00 website: http://www.biovendor.com/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO)	participant	625˙308.00
5	Askion GmbH Askion GmbH Organization address address: GEWERBEPARK KEPLERSTRASSE 17-19 city: GERA postcode: 7549 website: www.askion.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GERA)	participant	499˙250.00
6	CLINICAGENO LIMITED CLINICAGENO LIMITED Organization address address: STATION APPROACH 11 COULSDON NORTH city: COULSDON SURREY postcode: CR5 2NR website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (COULSDON SURREY)	participant	436˙208.00
7	MAGNAMEDICS DIAGNOSTICS BV MAGNAMEDICS DIAGNOSTICS BV Organization address address: DE ASSELEN KUIL 12 city: GELEEN postcode: 6161 RD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GELEEN)	participant	398˙317.00
8	SPARKS & CO SPARKS & CO Organization address address: 66 AVENUE DES CHAMPS ELYSEES ESPACE 41 city: PARIS postcode: 75008 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	121˙563.00
9	MAGTIVIO B.V. MAGTIVIO B.V. Organization address address: VLOTSTRAT 2-4 city: Heerlen postcode: 6417 CB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Heerlen)	participant	70˙432.00
10	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	16˙191.00
11	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	0.00

Map

Project objective

The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g., tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g., tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features.

Deliverables

List of deliverables.
D9.2 Questionnaires from EMC and UZH(PPC) for clinician, GP, and dentist feedback	Documents, reports	2020-02-26 16:30:53
D10.7 Project-related video	Websites, patent fillings, videos etc.	2020-02-26 16:30:53
D10.6 Two workshops organised at partners EMC, UZH and KI	Websites, patent fillings, videos etc.	2020-02-26 16:30:53
D10.3 Communication materials	Websites, patent fillings, videos etc.	2020-02-26 16:30:52
D10.1 Project website and intranet	Websites, patent fillings, videos etc.	2020-02-26 16:30:52

Take a look to the deliverables list in detail: detailed list of DIAGORAS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Alex van Belkum, Till T. Bachmann, Gerd LÃ¼dke, Jan Gorm Lisby, Gunnar Kahlmeter, Allan Mohess, Karsten Becker, John P. Hays, Neil Woodford, Konstantinos Mitsakakis, Jacob Moran-Gilad, Jordi Vila, Harald Peter, John H. Rex, Wm. Michael Dunne Developmental roadmap for antimicrobial susceptibility testing systems published pages: 51-62, ISSN: 1740-1526, DOI: 10.1038/s41579-018-0098-9	Nature Reviews Microbiology 17/1	2020-02-26
2018	Konstantinos Mitsakakis, Wendy E Kaman, Gijs Elshout, Mara Specht, John P Hays Challenges in identifying antibiotic resistance targets for point-of-care diagnostics in general practice published pages: 1157-1164, ISSN: 1746-0913, DOI: 10.2217/fmb-2018-0084	Future Microbiology 13/10	2020-02-26
2017	Georgios N. Belibasakis, Michael A. Curtis, George Hajishengallis, Egija Zaura Meeting report: The 12 th European oral microbiology workshop (EOMW) in Stockholm, Sweden published pages: 64-69, ISSN: 2150-5594, DOI: 10.1080/21505594.2017.1376147	Virulence 9/1	2020-02-26
2017	John P Hays Why is scientific research on â€˜data-poorâ€™ microorganisms being ignored? published pages: 645-650, ISSN: 1746-0913, DOI: 10.2217/fmb-2017-0061	Future Microbiology 12/8	2020-02-26
2017	Y. Zhao, G. Czilwik, V. Klein, K. Mitsakakis, R. Zengerle, N. Paust C-reactive protein and interleukin 6 microfluidic immunoassays with on-chip pre-stored reagents and centrifugo-pneumatic liquid control published pages: 1666-1677, ISSN: 1473-0197, DOI: 10.1039/c7lc00251c	Lab on a Chip 17/9	2020-02-26
2016	Wendy E Kaman, Gijs Elshout, Patrick JE Bindels, Konstantinos Mitsakakis, John P Hays Current problems associated with the microbiological point-of-care testing of respiratory tract infections in primary care published pages: 607-610, ISSN: 1746-0913, DOI: 10.2217/fmb-2015-0020	Future Microbiology 11/5	2020-02-26
2017	Annemiek A van der Eijk, Andrei N Tintu, John P Hays Pre-implementation guidelines for infectious disease point-of-care testing in medical institutions published pages: 51-58, ISSN: 1746-0913, DOI: 10.2217/fmb-2016-0120	Future Microbiology 12/1	2020-02-26

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The information about "DIAGORAS" are provided by the European Opendata Portal: CORDIS opendata.

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