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GLAM

Laser Multiplexed Biosensor

Total Cost €

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EC-Contrib. €

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Partnership

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Project "GLAM" data sheet

The following table provides information about the project.

Coordinator
ACONDICIONAMIENTO TARRASENSE ASSOCIACION 

Organization address
address: CARRER DE LA INNOVACIO 2
city: TERRASSA
postcode: 8225
website: www.leitat.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.glam-project.eu
 Total cost 4˙835˙584 €
 EC max contribution 4˙835˙584 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACONDICIONAMIENTO TARRASENSE ASSOCIACION ES (TERRASSA) coordinator 692˙632.00
2    UNIVERSITEIT TWENTE NL (ENSCHEDE) participant 817˙885.00
3    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 574˙275.00
4    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) participant 491˙125.00
5    NOVELIC DOO BEOGRAD-NOVI BEOGRAD RS (BEOGRAD) participant 467˙700.00
6    OBELIS SA BE (BRUXELLES) participant 409˙800.00
7    ALTER TECHNOLOGY TUV NORD UK LIMITED UK (LIVINGSTON) participant 400˙812.00
8    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 374˙412.00
9    WINZSOFT (ISRAEL) LTD IL (TEL AVIV-JAFFO) participant 323˙625.00
10    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 283˙316.00

Map

 Project objective

Differential cancer diagnosis takes place daily in clinical settings for a better monitoring of patient responses to existing treatments. However outcome of this diagnosis is today still poor. Moreover, current technology to measure biomarker levels is expensive and sophisticated. Most cancer biomarker analysis use blood or biological tissues as the main source of material. These biopsies must be analyzed in specialized laboratories incurring in some limitations: high cost; specialized personnel and equipment; large amounts of biological material; long outcome delivery time; time consuming processes. Therefore it exist a real need and urgency to have new diagnostic devices that provide diagnosis, prognosis, and monitoring data faster and with exquisite ultra-sensitivity on time to take the appropriate decisions to improve personalized diagnosis and therapy. The aim of GLAM project is to provide an innovative device to fulfill these requirements using soluble biomarkers for personalized diagnosis and therapy monitoring. Specifically we will design and develop a new diagnostic tool to detect biomarkers from biofluids obtained in a non-invasive manner, specifically focusing to urine and to genitourinary cancers, to help oncologist to take better treatment decisions, approaching personalized medicine. GLAM will develop an integrated device based on novel label-free photonic biosensors with ultra-sensitivity, simplicity of use, portability, multiplexing and low cost. GLAM capitalizes on the unprecedented sensitivity achieved using laser microring resonators to detect key biomarkers in tumor development and treatment. Point of Care of the device will be carried out by preclinical and clinical sample analysis of genitourinary cancer patients to warrant personalized medicine. Importantly the GLAM unique technology will make the device also usable with other biofluids and might also be used to help physicians with other biomarker driven.

 Deliverables

List of deliverables.
Report on the list of selected biomarkers to be used in later tasks Documents, reports 2020-02-06 13:10:05
Communication toolbox Documents, reports 2020-02-06 13:10:05

Take a look to the deliverables list in detail:  detailed list of GLAM deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Michiel de Goede, Lantian Chang, Jinfeng Mu, Meindert Dijkstra, Raquel Obregón, Elena Martínez, Laura Padilla, Francesc Mitjans, Sonia M. Garcia-Blanco
Al 2 O 3 :Yb 3+ integrated microdisk laser label-free biosensor
published pages: 5937, ISSN: 0146-9592, DOI: 10.1364/ol.44.005937
Optics Letters 44/24 2020-02-06
2019 Nirmalendu Acharyya, Gregory Kozyreff
Large Q Factor with Very Small Whispering-Gallery-Mode Resonators
published pages: , ISSN: 2331-7019, DOI: 10.1103/physrevapplied.12.014060
Physical Review Applied 12/1 2020-02-06
2018 M. de Goede, L. Chang, M. Dijkstra, S. M. García-Blanco
Integrated Al2O3:Yb3+ microring laser for on-chip active sensing in an aqueous environment
published pages: We.2.B.5. 74, ISSN: , DOI:
Proc. ECIO 2020-02-06
2019 Francesco Cutrale, Daniel Rodriguez, Verónica Hortigüela, Chi-Li Chiu, Jason Otterstrom, Stephen Mieruszynski, Anna Seriola, Enara Larrañaga, Angel Raya, Melike Lakadamyali, Scott E. Fraser, Elena Martinez, Samuel Ojosnegros
Using enhanced number and brightness to measure protein oligomerization dynamics in live cells
published pages: 616-638, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0111-9
Nature Protocols 14/2 2020-02-06
2019 Acharyya, Nirmalendu; Kozyreff, Gregory
Large Q factor with very small Whispering Gallery Modes resonators
published pages: , ISSN: , DOI:
1 2020-02-06
2017 Nirmalendu Acharyya, Gregory Kozyreff
Multiple Critical Couplings and Sensing in a Microresonator-Waveguide System
published pages: , ISSN: 2331-7019, DOI: 10.1103/PhysRevApplied.8.034029
Physical Review Applied 8/3 2020-02-06
2017 M. De Goede, M. Dijkstra, S.M. García-Blanco
Double Al2O3 microring resonator for self-referenced sensing applications
published pages: , ISSN: , DOI:
Proc. ECIO 2020-02-06
2017 Samuel Ojosnegros, Francesco Cutrale, Daniel Rodríguez, Jason J. Otterstrom, Chi Li Chiu, Verónica Hortigüela, Carolina Tarantino, Anna Seriola, Stephen Mieruszynski, Elena Martínez, Melike Lakadamyali, Angel Raya, Scott E. Fraser
Eph-ephrin signaling modulated by polymerization and condensation of receptors
published pages: 13188-13193, ISSN: 0027-8424, DOI: 10.1073/pnas.1713564114
Proceedings of the National Academy of Sciences 114/50 2020-02-06
2017 M. De Goede, M. Dijkstra, S.M. García-Blanco
High-Q Al2O3 microring resonator for sensing applications
published pages: , ISSN: , DOI:
Proc ECIO 2020-02-06
2015 Anna Lagunas, Elena Martínez, Josep Samitier
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2015.00132
Frontiers in Bioengineering and Biotechnology 3 2020-02-06
2016 A. Lagunas, B. Sasso, N. Tesson, C. Cantos, E. Martínez, J. Samitier
Synthesis of a polymethyl(methacrylate)-polystyrene-based diblock copolymer containing biotin for selective protein nanopatterning
published pages: 212-218, ISSN: 1759-9954, DOI: 10.1039/C5PY01601K
Polym. Chem. 7/1 2020-02-06
2016 Gregory Kozyreff, Nirmalendu Acharyya
Dispersion relations and bending losses of cylindrical and spherical shells, slabs, and slot waveguides
published pages: 28204, ISSN: 1094-4087, DOI: 10.1364/OE.24.028204
Optics Express 24/25 2020-02-06

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